公开(公告)号：US20240393501A1

公开(公告)日：2024-11-28

申请号：US18670852

申请日：2024-05-22

Applicant: Alcon Inc.

Inventor： Jack W. Trieu ,  Daqing Wu ,  Feng Jing ,  Steve Yun Zhang

IPC: G02B1/04 ,  C07F5/02 ,  G02B1/10

Abstract: The invention provides a method for producing coated silicone hydrogel contact lenses in a cost-effective manner. The method comprises obtaining a preformed silicone hydrogel contact lens comprising a bulk silicone hydrogel material that comprises repeating units of at least one carboxyl-containing vinylic monomer and at least one arylborono-containing vinylic monomer, and heating the preformed silicone hydrogel contact lens in an aqueous coating solution comprising a water-soluble and thermally crosslinkable polymeric material having azetidinium or epoxide groups and a diol-containing hydrophilic polymer having 1,2- or 1,3-diol moieties to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel coating that comprises a crosslinked polymeric material covalently attached onto the bulk silicone hydrogel material and a grafted diol-containing hydrophilic polymer covalently attached onto the bulk silicone hydrogel material and distributed in the crosslinked polymeric material.

公开(公告)号：US20240293985A1

公开(公告)日：2024-09-05

申请号：US18586910

申请日：2024-02-26

Applicant: Alcon Inc.

Inventor： Richard Charles Breitkopf ,  Feng Jing ,  Daqing Wu ,  Jack W. Trieu ,  Steve Yun Zhang

IPC: B29D11/00 ,  B29C33/40 ,  B29C35/02 ,  B29K83/00 ,  B29K105/00 ,  B29K105/16 ,  G02C7/04

CPC classification number: B29D11/00865 ,  B29C33/40 ,  B29C35/0227 ,  B29D11/00067 ,  B29D11/00125 ,  B29K2083/00 ,  B29K2105/0002 ,  B29K2105/0061 ,  B29K2105/16 ,  B29K2823/12 ,  B29K2995/0093 ,  G02C7/049

Abstract: The invention provides a method for producing coated silicone hydrogel contact lenses in a cost-effective manner. The method comprises treating the molding surfaces of polypropylene lens molds (or other hydrophobic plastic molds) with a vacuum UV or a corona plasma to increase the surface energies of the molding surfaces of the lens molds, cast-molding a silicone hydrogel lens formulation containing a relatively small amount of at least one carboxyl-containing vinylic monomer in the treated lens molds, and heating resultant cast-molded silicone hydrogel contact lenses in an aqueous coating solution comprising a water-soluble and thermally crosslinkable polymeric material to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel layer covalently attached onto the bulk silicone hydrogel material.

公开(公告)号：US20230103231A1

公开(公告)日：2023-03-30

申请号：US17823539

申请日：2022-08-31

Applicant: Alcon Inc.

Inventor： Daqing Wu ,  Feng Jing ,  Steve Yun Zhang ,  Junhao Ge ,  Jack W. Trieu

IPC: G02B1/04 ,  G02B1/14 ,  B29D11/00

Abstract: The invention provide a method for producing coated silicone hydrogel contact lenses in a cost-effective and environmentally friendly manner. The method is free of lens extraction step and comprises: curing thermally or actinically in a lens mold a polymerizable composition that comprises at least one hydrophilized polysiloxane vinylic crosslinker, hydroxyethyl methacrylate, C1-C2 alkoxyethyl (meth)acrylate, at least one free-radical initiator, and at least one solvent selected from the group consisting of water, propylene glycol, and/or a low-molecular weight polyethyleneglycol; and heating the cast-molded silicone hydrogel contact lens in an aqueous coating solution to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a layer of a crosslinked hydrophilic polymeric material that is covalently attached onto the bulk silicone hydrogel material. Resultant contact lenses are optically clear and wettable and have a relatively high oxygen permeability.