公开(公告)号：US20220324187A1

公开(公告)日：2022-10-13

申请号：US17710199

申请日：2022-03-31

Applicant: Alcon Inc.

Inventor： Zahra Bassampour ,  Chandana Kolluru ,  Steve Yun Zhang ,  Junhao Ge ,  Yang Zheng ,  Cornelius Daniel Niculas ,  David Andrew Icenogle ,  Jing Cheng ,  Yuan Chang ,  Augustine Twum Kumi ,  Michelle Plavnik

IPC: B29D11/00 ,  C08J3/075 ,  C08J3/24 ,  G02C7/04

Abstract: The invention relates to a method for producing embedded hydrogel contact lenses involving a set of 3-mold halves consisting essentially of: one female lens mold half having a molding surface defining the anterior surface of a contact lens; one male lens mold half having a molding surface defining the posterior surface of the contact lens; and an insert mold half having a molding surface defining one of the front and back surfaces of an insert. One of the lens mold halves is used twice: first with the insert mold half for molding an insert during first curing process and then with the other lens mold half for molding an embedded hydrogel contact lens with the molded insert embedded partially or fully therein during second curing process. The invention also relates to embedded hydrogel contact lenses produced from a method of the invention.

公开(公告)号：US12171871B2

公开(公告)日：2024-12-24

申请号：US17392448

申请日：2021-08-03

Applicant: ALCON INC.

Inventor： Junhao Ge ,  Steve Yun Zhang ,  Daqing Wu ,  Jing Cheng ,  Yuan Chang ,  Feng Jing ,  Jang-Shing Chiou ,  Stephen Raymond Perreault

IPC: A61K9/00 ,  A45C11/00 ,  A61K9/51 ,  A61K31/685 ,  A61L12/04 ,  B65B25/00

Abstract: The present invention relates to a method to load a water insoluble phospholipid as nanoparticles to load into a hydrogel contact lens in autoclaving process during the hydrogel contact lens manufacturing process without an extra manufacturing step and without swelling the hydrogel contact lens with an organic solvent. The phospholipid nanoparticles loaded in hydrogel contact lens subsequently releases to the eye upon wearing.

公开(公告)号：US11933941B2

公开(公告)日：2024-03-19

申请号：US17572794

申请日：2022-01-11

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  John Dallas Pruitt ,  Newton T. Samuel ,  Chung-Yuan Chiang ,  Robert Carey Tucker ,  Yuan Chang ,  Ethan Leveillee

IPC: G02B1/04 ,  B05D5/00 ,  B29D11/00 ,  B29K105/00 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/04 ,  B05D1/18 ,  B05D1/38 ,  B05D3/00 ,  B05D3/02 ,  B05D5/10 ,  B29K83/00

CPC classification number: G02B1/043 ,  B05D5/00 ,  B29D11/00038 ,  B29D11/00125 ,  B29D11/00865 ,  B65B55/22 ,  C08L33/02 ,  C08L79/04 ,  C08L83/04 ,  C09D133/02 ,  G02B1/18 ,  G02C7/049 ,  B05D1/18 ,  B05D1/38 ,  B05D3/002 ,  B05D3/02 ,  B05D5/10 ,  B29K2083/00 ,  B29K2105/0061 ,  C08L2201/10 ,  C08L2201/54 ,  G02B2207/109 ,  G02B1/043 ,  C08L83/04

Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.

公开(公告)号：US20220365371A1

公开(公告)日：2022-11-17

申请号：US17661121

申请日：2022-04-28

Applicant: Alcon Inc.

Inventor： Junhao Ge ,  Richard Charles Breitkopf ,  Steve Yun Zhang ,  Yuan Chang ,  Augustine Twum Kumi

IPC: G02C7/10 ,  G02B1/04 ,  G02C7/04

Abstract: The invention is directed to a colored cosmetic photochromic contact lens, comprising: a pupil section, a generally annular iris section surrounding the pupil section, wherein at least the pupil section is photochromic, wherein the iris section having a colored, printed, opaque, intermittent pattern, wherein the said pattern is covered by a clear ink layer, wherein the clear ink layer is on outer surface of lens to the observer.

公开(公告)号：US20220326412A1

公开(公告)日：2022-10-13

申请号：US17710224

申请日：2022-03-31

Applicant: Alcon Inc.

Inventor： Yuan Chang ,  Junhao Ge ,  Ying Pi ,  Cornelius Daniel Niculas ,  Yang Zheng ,  Steve Yun Zhang ,  Michelle Plavnik ,  Ethan Leveillee ,  Jing Cheng ,  Augustine Twum Kumi

IPC: G02B1/04 ,  C08G77/442 ,  B29D11/00 ,  G02C7/04

Abstract: The invention is directed to an embedded hydrogel contact lens, which comprises an insert sandwiched between two layers of hydrogel materials and can be produced according to a cast molding method including the procedures involving two females halves (FC1 and FC2) and two male halves (BC1 and BC2) and three consequential molding steps involving three molding assemblies: the 1st one formed between FC1 and BC1 for molding an insert; the 2nd one formed between FC1 and BC2 for molding a lens precursor having the molded insert embedded in a layer of a hydrogel material in a way that the front surface of the molded insert merges with the convex surface of the lens precursor; and the 3rd one formed between FC2 and BC2 for molding an embedded hydrogel contact of the invention.

公开(公告)号：US20220134692A1

公开(公告)日：2022-05-05

申请号：US17518432

申请日：2021-11-03

Applicant: Alcon Inc.

Inventor： Yuan Chang ,  Junhao Ge ,  Steve Yun Zhang

IPC: B29D11/00 ,  C08F2/48 ,  G02B1/04

Abstract: Described herein is a method for producing photochromic contact lenses, in particular, photochromic silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including a vinylic monomer having a primary amino or thiolactone group to form an unprocessed contact lens having the polymer matrix of which have pendant primary amino or thiolactone groups, a step of one-pot multistep reactions based on thiolactone chemistry (aminolysis and thiol-induced graft polymerization of a photochromic vinylic monomer to the polymer matrix) which are carried out only in its central region which is circular and concentric with the central axis of the unprocessed contact lens. The obtained photochromic contact lens has a central pupillary region that only can undergo a reversible color change upon exposure to UV/HEVL-radiation.