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公开(公告)号：US11513257B2
公开(公告)日：2022-11-29
申请号：US17122109
申请日：2020-12-15
Applicant: Alcon Inc.
Inventor： Ying Zheng , Jang-Shing Chiou , Jinbo Dou , Yuan Chang , Junhao Ge , Steve Yun Zhang , Li Yao , Karen Belinda Sentell , Ye Hong
Abstract: The invention relates to an ophthalmic product which comprises a sealed and autoclave-sterilized lens package including (1) a post-autoclave packaging solution containing a polymeric surfactant having an HLB value of from about 11 to about 16 and a Mn of from about 800 to about 20,000 Daltons and (2) a readily-usable silicone hydrogel (SiHy) contact lens immersed in the packaging solution. The readily-usable SiHy contact lens comprises the polymeric surfactant thereon providing an excellent wettability to the readily-usable SiHy contact lens directly out of the lens package, and also the leachable polymeric surfactant which is physically distributed in the polymer matrix of the SiHy contact lens and can be released to the eye of a patient for at least 7 days of daily wear and to replenish the lens surface-bound polymeric surfactant to provide sustainable wettabilities to the contact lens and the eye.
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公开(公告)号：US12171870B2
公开(公告)日：2024-12-24
申请号：US17392425
申请日：2021-08-03
Applicant: ALCON INC.
Inventor： Jing Cheng , Stephen Raymond Perreault , Daqing Wu , Steve Yun Zhang , Jang-Shing Chiou
Abstract: The present invention relates to a method to load a water insoluble phospholipid as nanoparticles to load into a hydrogel contact lens in autoclaving process during the hydrogel contact lens manufacturing process without an extra manufacturing step and without swelling the hydrogel contact lens with an organic solvent. The phospholipid nanoparticles loaded in hydrogel contact lens subsequently releases to the eye upon wearing.
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公开(公告)号：US20210181379A1
公开(公告)日：2021-06-17
申请号：US17122109
申请日：2020-12-15
Applicant: Alcon Inc.
Inventor： Ying Zheng , Jang-Shing Chiou , Jinbo Dou , Yuan Chang , Junhao Ge , Steve Yun Zhang , Li Yao , Karen Belinda Sentell , Ye Hong
Abstract: The invention relates to an ophthalmic product which comprises a sealed and autoclave-sterilized lens package including (1) a post-autoclave packaging solution containing a polymeric surfactant having an HLB value of from about 11 to about 16 and a Mn of from about 800 to about 20,000 Daltons and (2) a readily-usable silicone hydrogel (SiHy) contact lens immersed in the packaging solution. The readily-usable SiHy contact lens comprises the polymeric surfactant thereon providing an excellent wettability to the readily-usable SiHy contact lens directly out of the lens package, and also the leachable polymeric surfactant which is physically distributed in the polymer matrix of the SiHy contact lens and can be released to the eye of a patient for at least 7 days of daily wear and to replenish the lens surface-bound polymeric surfactant to provide sustainable wettabilities to the contact lens and the eye.
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公开(公告)号：US12171871B2
公开(公告)日：2024-12-24
申请号：US17392448
申请日：2021-08-03
Applicant: ALCON INC.
Inventor： Junhao Ge , Steve Yun Zhang , Daqing Wu , Jing Cheng , Yuan Chang , Feng Jing , Jang-Shing Chiou , Stephen Raymond Perreault
Abstract: The present invention relates to a method to load a water insoluble phospholipid as nanoparticles to load into a hydrogel contact lens in autoclaving process during the hydrogel contact lens manufacturing process without an extra manufacturing step and without swelling the hydrogel contact lens with an organic solvent. The phospholipid nanoparticles loaded in hydrogel contact lens subsequently releases to the eye upon wearing.
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