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公开(公告)号：US20220126541A1
公开(公告)日：2022-04-28
申请号：US17512431
申请日：2021-10-27
Applicant: Alcon Inc.
Inventor： Junhao Ge , Yuan Chang , Steve Yun Zhang , Michelle Plavnik , Augustine Twum Kumi , Daqing Wu
IPC: B29D11/00 , G02C7/04 , G02C7/10 , C08F230/08
Abstract: Described herein is a method for producing photochromic silicone hydrogel contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The main polymerizable components in the polymerizable composition are a high radical-reactive hydrophilic (meth)acrylamido monomer, a high radical-reactive siloxane-containing (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker(s) free of low-reactive ethylenically unsaturated group as the main crosslinker. The thermal free radical initiator having a 10 hour half-life temperature (T10hλ) of from about 50° C. to about 90° C. The controlled thermal curing scheme includes maintaining a first curing temperature of from about (T10hλ−20)° C. to about T10hλ° C. for a first curing time and maintaining a second curing temperature of from about (T10hλ+10)° C. to about (T10hλ+35)° C. for a second curing time.
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公开(公告)号：US20210181379A1
公开(公告)日：2021-06-17
申请号：US17122109
申请日：2020-12-15
Applicant: Alcon Inc.
Inventor： Ying Zheng , Jang-Shing Chiou , Jinbo Dou , Yuan Chang , Junhao Ge , Steve Yun Zhang , Li Yao , Karen Belinda Sentell , Ye Hong
Abstract: The invention relates to an ophthalmic product which comprises a sealed and autoclave-sterilized lens package including (1) a post-autoclave packaging solution containing a polymeric surfactant having an HLB value of from about 11 to about 16 and a Mn of from about 800 to about 20,000 Daltons and (2) a readily-usable silicone hydrogel (SiHy) contact lens immersed in the packaging solution. The readily-usable SiHy contact lens comprises the polymeric surfactant thereon providing an excellent wettability to the readily-usable SiHy contact lens directly out of the lens package, and also the leachable polymeric surfactant which is physically distributed in the polymer matrix of the SiHy contact lens and can be released to the eye of a patient for at least 7 days of daily wear and to replenish the lens surface-bound polymeric surfactant to provide sustainable wettabilities to the contact lens and the eye.
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公开(公告)号：US20240176047A1
公开(公告)日：2024-05-30
申请号：US18436094
申请日：2024-02-08
Applicant: Alcon Inc.
Inventor： Yongxing Qiu , John Dallas Pruitt , Newton T. Samuel , Chung-Yuan Chiang , Robert Carey Tucker , Yuan Chang , Ethan Leveillee
IPC: G02B1/04 , B05D1/18 , B05D1/38 , B05D3/00 , B05D3/02 , B05D5/00 , B05D5/10 , B29D11/00 , B29K83/00 , B29K105/00 , B65B55/22 , C08L33/02 , C08L79/04 , C08L83/04 , C09D133/02 , G02B1/18 , G02C7/04
CPC classification number: G02B1/043 , B05D5/00 , B29D11/00038 , B29D11/00125 , B29D11/00865 , B65B55/22 , C08L33/02 , C08L79/04 , C08L83/04 , C09D133/02 , G02B1/18 , G02C7/049 , B05D1/18 , B05D1/38 , B05D3/002 , B05D3/02 , B05D5/10 , B29K2083/00 , B29K2105/0061 , C08L2201/10 , C08L2201/54 , G02B2207/109
Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.
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公开(公告)号：US11927512B2
公开(公告)日：2024-03-12
申请号：US17087983
申请日：2020-11-03
Applicant: Alcon Inc.
Inventor： Yuan Chang , Ying Zheng , Junhao Ge , Steve Yun Zhang , Karen Belinda Sentell , Jinbo Dou
CPC classification number: G01N1/30 , G01N1/04 , G01N21/77 , G02B1/043 , G01N2001/302 , G01N2021/7786
Abstract: The invention provides a method for imaging and thickness determination of coatings on coated contact lenses. The method comprises selectively staining a negatively-charged-groups-containing coating over the lens body of a coated contact lens by immersing the coated contact lens in an aqueous solution comprising a fluorescently-labeled polycationic polymer and having a pH of from about 6.5 to 8.0; orthogonally cutting the selectively-stained coated contact lens; and determining the thickness of the coating on the coated contact lens. In addition, the invention provides a method for selecting a candidate coating material comprising negatively charged groups for applying a coating with a desired thickness onto silicone hydrogel contact lenses and for optimizing a coating process for producing coated silicone hydrogel contact lenses with a desired thickness coating thereon.
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公开(公告)号：US20230166467A1
公开(公告)日：2023-06-01
申请号：US18070189
申请日：2022-11-28
Applicant: Alcon Inc.
Inventor： Yang Zheng , Cornelius Daniel Niculas , Yuan Chang , Junhao Ge , Steve Yun Zhang , Justin Joel Aguayo , David Andrew Icenogle , Muhammad Waqas Asif , Daryl Reece
CPC classification number: B29D11/00519 , B29D11/00038 , G02B1/043 , G02C7/04 , B29K2083/00
Abstract: Systems, devices, and methods are disclosed for fabricating a hybrid contact lens product having a lens insert embedded at a precisely controlled location within a lens body. A mold engagement and support base engages and retains a lens forming mold in a substantially fixed position. An insert placement and positioning device includes an insert pickup head with a contact face configured for releasable engagement of the lens insert and at least one suction opening in the contact face for applying suction to engage the insert on the contact face. A positioning housing interacts with the mold and/or the support base to provide precise locational positioning of the lens insert within the mold. A lens body forming material is delivered to the mold to encapsulate the lens insert.
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Patent Agency Ranking
公开(公告)号：US20230117502A1
公开(公告)日：2023-04-20
申请号：US18047312
申请日：2022-10-18
Applicant: Alcon Inc.
Inventor： Michelle Plavnik , Junhao Ge , Steve Yun Zhang , Ethan Leveillee , Yang Zheng , Yuan Chang
IPC: B29D11/00
Abstract: A dosing system and method for delivery of contact lens formulation(s) to a contact lens forming mold. The system includes a carrier portion configured for holding a contact lens mold, and an alignment mandrel configured for retaining a lens formulation delivery device. The lens formulation delivery device is retained in a specified position relative to the contact lens mold for precise location of delivery of the lens formulation within the contact lens mold. A first lens formulation can be dosed to a center location in the mold, and a different second lens formulation can be dosed to a ring-shaped pattern around the center location, to form a contact lens having different center and edge characteristics.
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公开(公告)号：US20220137433A1
公开(公告)日：2022-05-05
申请号：US17518423
申请日：2021-11-03
Applicant: Alcon Inc.
Inventor： Yuan Chang , Junhao Ge , Steve Yun Zhang , Michelle Plavnik , Augustine Twum Kumi
Abstract: Described herein is a method for producing photochromic contact lenses, in particular, photochromic silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including an iniferter to form an unprocessed contact lens having iniferter moieties covalently incorporated into its polymer matrix and a step of iniferter-induced graft-polymerization of a photochromic vinylic monomer to the polymer matrix only in its central region which is circular and concentric with the central axis of the unprocessed contact lens. The obtained photochromic contact lens has a central pupillary region that only can undergo a reversible color change upon exposure to UV/HEVL-radiation.
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公开(公告)号：US20210284806A1
公开(公告)日：2021-09-16
申请号：US17199158
申请日：2021-03-11
Applicant: Alcon Inc.
Inventor： Yuan Chang , Junhao Ge , Steve Yun Zhang , Weihong Lang
IPC: C08G77/388 , C08L83/08
Abstract: The invention provides a class of photochromic polydiorganosiloxane vinylic crosslinkers. Each of the photochromic polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and photochromic siloxane unit having one methyl substituent and one organic substituent having a photochromic moiety that capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light; (2) two terminal ethylenically-unsaturated groups. The invention also provides a soft photochromic contact lens, especially a photochromic silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers. The invention further provides a method of producing a photochromic contact lens from a polymerizable composition comprising at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers.
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公开(公告)号：US20210131923A1
公开(公告)日：2021-05-06
申请号：US17087983
申请日：2020-11-03
Applicant: Alcon Inc.
Inventor： Yuan Chang , Ying Zheng , Junhao Ge , Steve Yun Zhang , Karen Belinda Sentell , Jinbo Dou
Abstract: The invention provides a method for imaging and thickness determination of coatings on coated contact lenses. The method comprises selectively staining a negatively-charged-groups-containing coating over the lens body of a coated contact lens by immersing the coated contact lens in an aqueous solution comprising a fluorescently-labeled polycationic polymer and having a pH of from about 6.5 to 8.0; orthogonally cutting the selectively-stained coated contact lens; and determining the thickness of the coating on the coated contact lens. In addition, the invention provides a method for selecting a candidate coating material comprising negatively charged groups for applying a coating with a desired thickness onto silicone hydrogel contact lenses and for optimizing a coating process for producing coated silicone hydrogel contact lenses with a desired thickness coating thereon.
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公开(公告)号：US12270968B2
公开(公告)日：2025-04-08
申请号：US18436094
申请日：2024-02-08
Applicant: Alcon Inc.
Inventor： Yongxing Qiu , John Dallas Pruitt , Newton T. Samuel , Chung-Yuan Chiang , Robert Carey Tucker , Yuan Chang , Ethan Leveillee
IPC: G02B1/04 , B05D5/00 , B29D11/00 , B29K105/00 , B65B55/22 , C08L33/02 , C08L79/04 , C08L83/04 , C09D133/02 , G02B1/18 , G02C7/04 , B05D1/18 , B05D1/38 , B05D3/00 , B05D3/02 , B05D5/10 , B29K83/00
Abstract: The invention is related to contact lenses that not only comprise the much desired water gradient structural configurations, but also have a minimized uptakes of polycationic antimicrobials and a long-lasting surface hydrophilicity and wettability even after going through a 30-days lens care regime. Because of the water gradient structural configuration and a relatively-thick, extremely-soft and water-rich hydrogel surface layer, a contact lens of the invention can provide superior wearing comfort. Further, a contact lens of the invention is compatible with multipurpose lens care solutions present in the market and can endure the harsh lens care handling conditions (e.g., digital rubbings, accidental inversion of contact lenses, etc.) encountered in a daily lens care regime. As such, they are suitable to be used as weekly- or monthly-disposable water gradient contact lenses.
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