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    Method for producing embedded or hybrid hydrogel contact lenses
    1.
    发明授权
    Method for producing embedded or hybrid hydrogel contact lenses 有权

    公开(公告)号：US11833770B2

    公开(公告)日：2023-12-05

    申请号：US17205148

    申请日：2021-03-18

    Applicant: Alcon Inc.

    Inventor： Yang Zheng ,  Junhao Ge ,  Steve Yun Zhang

    IPC: B29D11/00 ,  G02B1/04 ,  C08J3/075 ,  C08J3/24 ,  C08L83/04

    CPC classification number: B29D11/00038 ,  C08J3/075 ,  C08J3/24 ,  C08L83/04 ,  G02B1/043 ,  C08L2203/02

    Abstract: The invention is generally related to a method for producing, in a relatively efficient and consistent manner, embedded or hybrid silicone hydrogel contact lenses, and also to unprocessed embedded or hybrid silicone hydrogel contact lenses, according to conventional cast-molding technologies. A method of the invention involve use of a polymeric non-reactive diluent in preparing a polymerizable composition for forming the silicone hydrogel material of the unprocessed embedded or hybrid silicone hydrogel contact lens, which is cast-molded with a lens mold. The unprocessed cast-molded embedded or hybrid silicone hydrogel contact lens has no or a minimal water-swelling degree, so that lens distortion or delamination during the hydration of the unprocessed embedded or hybrid silicone hydrogel contact lens.

    METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES
    3.
    发明申请
    METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES 有权

    公开(公告)号：US20220126541A1

    公开(公告)日：2022-04-28

    申请号：US17512431

    申请日：2021-10-27

    Applicant: Alcon Inc.

    Inventor： Junhao Ge ,  Yuan Chang ,  Steve Yun Zhang ,  Michelle Plavnik ,  Augustine Twum Kumi ,  Daqing Wu

    IPC: B29D11/00 ,  G02C7/04 ,  G02C7/10 ,  C08F230/08

    Abstract: Described herein is a method for producing photochromic silicone hydrogel contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The main polymerizable components in the polymerizable composition are a high radical-reactive hydrophilic (meth)acrylamido monomer, a high radical-reactive siloxane-containing (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker(s) free of low-reactive ethylenically unsaturated group as the main crosslinker. The thermal free radical initiator having a 10 hour half-life temperature (T10hλ) of from about 50° C. to about 90° C. The controlled thermal curing scheme includes maintaining a first curing temperature of from about (T10hλ−20)° C. to about T10hλ° C. for a first curing time and maintaining a second curing temperature of from about (T10hλ+10)° C. to about (T10hλ+35)° C. for a second curing time.

    WETTABLE SILICONE HYDROGEL CONTACT LENSES
    4.
    发明申请
    WETTABLE SILICONE HYDROGEL CONTACT LENSES 有权

    公开(公告)号：US20210181379A1

    公开(公告)日：2021-06-17

    申请号：US17122109

    申请日：2020-12-15

    Applicant: Alcon Inc.

    Inventor： Ying Zheng ,  Jang-Shing Chiou ,  Jinbo Dou ,  Yuan Chang ,  Junhao Ge ,  Steve Yun Zhang ,  Li Yao ,  Karen Belinda Sentell ,  Ye Hong

    IPC: G02B1/04 ,  B65B25/00 ,  G02C7/04 ,  C08L71/02 ,  C08L39/06 ,  C08L83/04

    Abstract: The invention relates to an ophthalmic product which comprises a sealed and autoclave-sterilized lens package including (1) a post-autoclave packaging solution containing a polymeric surfactant having an HLB value of from about 11 to about 16 and a Mn of from about 800 to about 20,000 Daltons and (2) a readily-usable silicone hydrogel (SiHy) contact lens immersed in the packaging solution. The readily-usable SiHy contact lens comprises the polymeric surfactant thereon providing an excellent wettability to the readily-usable SiHy contact lens directly out of the lens package, and also the leachable polymeric surfactant which is physically distributed in the polymer matrix of the SiHy contact lens and can be released to the eye of a patient for at least 7 days of daily wear and to replenish the lens surface-bound polymeric surfactant to provide sustainable wettabilities to the contact lens and the eye.

    Method for determining coating thickness on coated contact lenses
    6.
    发明授权
    Method for determining coating thickness on coated contact lenses 有权

    公开(公告)号：US11927512B2

    公开(公告)日：2024-03-12

    申请号：US17087983

    申请日：2020-11-03

    Applicant: Alcon Inc.

    Inventor： Yuan Chang ,  Ying Zheng ,  Junhao Ge ,  Steve Yun Zhang ,  Karen Belinda Sentell ,  Jinbo Dou

    IPC: G01N1/30 ,  G01N1/04 ,  G01N21/77 ,  G02B1/04

    CPC classification number: G01N1/30 ,  G01N1/04 ,  G01N21/77 ,  G02B1/043 ,  G01N2001/302 ,  G01N2021/7786

    Abstract: The invention provides a method for imaging and thickness determination of coatings on coated contact lenses. The method comprises selectively staining a negatively-charged-groups-containing coating over the lens body of a coated contact lens by immersing the coated contact lens in an aqueous solution comprising a fluorescently-labeled polycationic polymer and having a pH of from about 6.5 to 8.0; orthogonally cutting the selectively-stained coated contact lens; and determining the thickness of the coating on the coated contact lens. In addition, the invention provides a method for selecting a candidate coating material comprising negatively charged groups for applying a coating with a desired thickness onto silicone hydrogel contact lenses and for optimizing a coating process for producing coated silicone hydrogel contact lenses with a desired thickness coating thereon.

    FORMULATION DOSING DEVICE FOR CONTACT LENS FABRICATION
    9.
    发明申请
    FORMULATION DOSING DEVICE FOR CONTACT LENS FABRICATION 有权

    公开(公告)号：US20230117502A1

    公开(公告)日：2023-04-20

    申请号：US18047312

    申请日：2022-10-18

    Applicant: Alcon Inc.

    Inventor： Michelle Plavnik ,  Junhao Ge ,  Steve Yun Zhang ,  Ethan Leveillee ,  Yang Zheng ,  Yuan Chang

    IPC: B29D11/00

    Abstract: A dosing system and method for delivery of contact lens formulation(s) to a contact lens forming mold. The system includes a carrier portion configured for holding a contact lens mold, and an alignment mandrel configured for retaining a lens formulation delivery device. The lens formulation delivery device is retained in a specified position relative to the contact lens mold for precise location of delivery of the lens formulation within the contact lens mold. A first lens formulation can be dosed to a center location in the mold, and a different second lens formulation can be dosed to a ring-shaped pattern around the center location, to form a contact lens having different center and edge characteristics.

    METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES
    10.
    发明申请
    METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES 有权

    公开(公告)号：US20220137433A1

    公开(公告)日：2022-05-05

    申请号：US17518423

    申请日：2021-11-03

    Applicant: Alcon Inc.

    Inventor： Yuan Chang ,  Junhao Ge ,  Steve Yun Zhang ,  Michelle Plavnik ,  Augustine Twum Kumi

    IPC: G02C7/04 ,  C08J7/18 ,  G02C7/10 ,  G02B1/04 ,  B29D11/00

    Abstract: Described herein is a method for producing photochromic contact lenses, in particular, photochromic silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including an iniferter to form an unprocessed contact lens having iniferter moieties covalently incorporated into its polymer matrix and a step of iniferter-induced graft-polymerization of a photochromic vinylic monomer to the polymer matrix only in its central region which is circular and concentric with the central axis of the unprocessed contact lens. The obtained photochromic contact lens has a central pupillary region that only can undergo a reversible color change upon exposure to UV/HEVL-radiation.

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