公开(公告)号：US20220326412A1

公开(公告)日：2022-10-13

申请号：US17710224

申请日：2022-03-31

Applicant: Alcon Inc.

Inventor： Yuan Chang ,  Junhao Ge ,  Ying Pi ,  Cornelius Daniel Niculas ,  Yang Zheng ,  Steve Yun Zhang ,  Michelle Plavnik ,  Ethan Leveillee ,  Jing Cheng ,  Augustine Twum Kumi

IPC: G02B1/04 ,  C08G77/442 ,  B29D11/00 ,  G02C7/04

Abstract: The invention is directed to an embedded hydrogel contact lens, which comprises an insert sandwiched between two layers of hydrogel materials and can be produced according to a cast molding method including the procedures involving two females halves (FC1 and FC2) and two male halves (BC1 and BC2) and three consequential molding steps involving three molding assemblies: the 1st one formed between FC1 and BC1 for molding an insert; the 2nd one formed between FC1 and BC2 for molding a lens precursor having the molded insert embedded in a layer of a hydrogel material in a way that the front surface of the molded insert merges with the convex surface of the lens precursor; and the 3rd one formed between FC2 and BC2 for molding an embedded hydrogel contact of the invention.

公开(公告)号：US11365288B2

公开(公告)日：2022-06-21

申请号：US17038293

申请日：2020-09-30

Applicant: Alcon Inc.

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Junhao Ge ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: C08G77/442 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G77/14 ,  C08L83/10 ,  G02B1/04 ,  C08G77/12 ,  B29D11/00 ,  G02C7/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US20220134692A1

公开(公告)日：2022-05-05

申请号：US17518432

申请日：2021-11-03

Applicant: Alcon Inc.

Inventor： Yuan Chang ,  Junhao Ge ,  Steve Yun Zhang

IPC: B29D11/00 ,  C08F2/48 ,  G02B1/04

Abstract: Described herein is a method for producing photochromic contact lenses, in particular, photochromic silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including a vinylic monomer having a primary amino or thiolactone group to form an unprocessed contact lens having the polymer matrix of which have pendant primary amino or thiolactone groups, a step of one-pot multistep reactions based on thiolactone chemistry (aminolysis and thiol-induced graft polymerization of a photochromic vinylic monomer to the polymer matrix) which are carried out only in its central region which is circular and concentric with the central axis of the unprocessed contact lens. The obtained photochromic contact lens has a central pupillary region that only can undergo a reversible color change upon exposure to UV/HEVL-radiation.

公开(公告)号：US11945895B2

公开(公告)日：2024-04-02

申请号：US17199158

申请日：2021-03-11

Applicant: Alcon Inc.

Inventor： Yuan Chang ,  Junhao Ge ,  Steve Yun Zhang ,  Weihong Lang

IPC: C08F283/12 ,  C08G77/06 ,  C08G77/388 ,  C08G77/442 ,  C08L83/08 ,  C08L83/12 ,  C09K9/02 ,  G02B1/04

CPC classification number: C08F283/124 ,  C08G77/06 ,  C08G77/388 ,  C08G77/442 ,  C08L83/08 ,  C08L83/12 ,  C09K9/02 ,  G02B1/043 ,  C08G2210/00 ,  C08L2312/06 ,  C09K2211/1088 ,  G02B2207/109

Abstract: The invention provides a class of photochromic polydiorganosiloxane vinylic crosslinkers. Each of the photochromic polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and photochromic siloxane unit having one methyl substituent and one organic substituent having a photochromic moiety that capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light; (2) two terminal ethylenically-unsaturated groups. The invention also provides a soft photochromic contact lens, especially a photochromic silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers. The invention further provides a method of producing a photochromic contact lens from a polymerizable composition comprising at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers.

公开(公告)号：US11945181B2

公开(公告)日：2024-04-02

申请号：US17512431

申请日：2021-10-27

Applicant: Alcon Inc.

Inventor： Junhao Ge ,  Yuan Chang ,  Steve Yun Zhang ,  Michelle Plavnik ,  Augustine Twum Kumi ,  Daqing Wu

IPC: B29D11/00 ,  C08F230/08 ,  G02C7/04 ,  G02C7/10 ,  B29K33/00 ,  B29K83/00 ,  B29K105/00

CPC classification number: B29D11/00653 ,  B29D11/00076 ,  B29D11/00134 ,  C08F230/08 ,  G02C7/04 ,  G02C7/102 ,  B29K2033/26 ,  B29K2083/00 ,  B29K2105/0002 ,  B29K2105/0061 ,  B29K2823/10 ,  B29K2995/0046 ,  B29K2995/0065

Abstract: Described herein is a method for producing photochromic silicone hydrogel contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The main polymerizable components in the polymerizable composition are a high radical-reactive hydrophilic (meth)acrylamido monomer, a high radical-reactive siloxane-containing (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker(s) free of low-reactive ethylenically unsaturated group as the main crosslinker. The thermal free radical initiator having a 10 hour half-life temperature (T10hλ) of from about 50° C. to about 90° C. The controlled thermal curing scheme includes maintaining a first curing temperature of from about (T10hλ−20)° C. to about T10hλ° C. for a first curing time and maintaining a second curing temperature of from about (T10hλ+10)° C. to about (T10hλ+35)° C. for a second curing time.

公开(公告)号：US11886045B2

公开(公告)日：2024-01-30

申请号：US17518423

申请日：2021-11-03

Applicant: Alcon Inc.

Inventor： Yuan Chang ,  Junhao Ge ,  Steve Yun Zhang ,  Michelle Plavnik ,  Augustine Twum Kumi

IPC: G02C7/04 ,  B29D11/00 ,  C08J7/18 ,  G02B1/04 ,  G02C7/10

CPC classification number: G02C7/049 ,  B29D11/00048 ,  C08J7/18 ,  G02B1/043 ,  G02C7/102 ,  C08J2300/00 ,  C08J2451/00

Abstract: Described herein is a method for producing photochromic contact lenses, in particular, photochromic silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including an iniferter to form an unprocessed contact lens having iniferter moieties covalently incorporated into its polymer matrix and a step of iniferter-induced graft-polymerization of a photochromic vinylic monomer to the polymer matrix only in its central region which is circular and concentric with the central axis of the unprocessed contact lens. The obtained photochromic contact lens has a central pupillary region that only can undergo a reversible color change upon exposure to UV/HEVL-radiation.

公开(公告)号：US20230103231A1

公开(公告)日：2023-03-30

申请号：US17823539

申请日：2022-08-31

Applicant: Alcon Inc.

Inventor： Daqing Wu ,  Feng Jing ,  Steve Yun Zhang ,  Junhao Ge ,  Jack W. Trieu

IPC: G02B1/04 ,  G02B1/14 ,  B29D11/00

Abstract: The invention provide a method for producing coated silicone hydrogel contact lenses in a cost-effective and environmentally friendly manner. The method is free of lens extraction step and comprises: curing thermally or actinically in a lens mold a polymerizable composition that comprises at least one hydrophilized polysiloxane vinylic crosslinker, hydroxyethyl methacrylate, C1-C2 alkoxyethyl (meth)acrylate, at least one free-radical initiator, and at least one solvent selected from the group consisting of water, propylene glycol, and/or a low-molecular weight polyethyleneglycol; and heating the cast-molded silicone hydrogel contact lens in an aqueous coating solution to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a layer of a crosslinked hydrophilic polymeric material that is covalently attached onto the bulk silicone hydrogel material. Resultant contact lenses are optically clear and wettable and have a relatively high oxygen permeability.

公开(公告)号：US11513257B2

公开(公告)日：2022-11-29

申请号：US17122109

申请日：2020-12-15

Applicant: Alcon Inc.

Inventor： Ying Zheng ,  Jang-Shing Chiou ,  Jinbo Dou ,  Yuan Chang ,  Junhao Ge ,  Steve Yun Zhang ,  Li Yao ,  Karen Belinda Sentell ,  Ye Hong

IPC: C08L39/06 ,  G02B1/04 ,  B65B25/00 ,  C08L71/02 ,  C08L83/04 ,  G02C7/04

Abstract: The invention relates to an ophthalmic product which comprises a sealed and autoclave-sterilized lens package including (1) a post-autoclave packaging solution containing a polymeric surfactant having an HLB value of from about 11 to about 16 and a Mn of from about 800 to about 20,000 Daltons and (2) a readily-usable silicone hydrogel (SiHy) contact lens immersed in the packaging solution. The readily-usable SiHy contact lens comprises the polymeric surfactant thereon providing an excellent wettability to the readily-usable SiHy contact lens directly out of the lens package, and also the leachable polymeric surfactant which is physically distributed in the polymer matrix of the SiHy contact lens and can be released to the eye of a patient for at least 7 days of daily wear and to replenish the lens surface-bound polymeric surfactant to provide sustainable wettabilities to the contact lens and the eye.

公开(公告)号：US11439661B2

公开(公告)日：2022-09-13

申请号：US16911833

申请日：2020-06-25

Applicant: ALCON INC.

Inventor： Steve Yun Zhang ,  Richard Charles Breitkopf ,  Daqing Wu ,  Junhao Ge ,  Maria F. Gubitosi Raspino ,  Augustine Twum Kumi ,  Wei Liang

IPC: A61K31/80 ,  A61P27/04 ,  A61K31/015 ,  A61K31/07 ,  A61K31/122 ,  A61K31/202 ,  A61K31/355 ,  A61K31/593 ,  A61K31/736 ,  A61K45/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

Abstract: The invention is generally related to topical ophthalmic compositions comprising: from about 0.05 w/v % to about 5 w/v % of galactomannan polymer; a cis-diol and about 0.5 w/v % to about 10 w/v % of a hydrophilic copolymer which comprises (a) arylborono-containing repeating units each having a boronic acid, (b) repeating units of at least one phosphorylcholine-containing vinylic monomer, and (c) acrylic monomeric units of at least one acrylic monomer having 3 to 16 carbon atoms, the ophthalmic composition is substantially free of a borate for improving lubrication, hydration and drug delivery property.

公开(公告)号：US20220275154A1

公开(公告)日：2022-09-01

申请号：US17742559

申请日：2022-05-12

Applicant: Alcon Inc.

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Junhao Ge ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: C08G77/442 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G77/14 ,  C08L83/10 ,  G02B1/04 ,  C08G77/12 ,  B29D11/00 ,  G02C7/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.