公开(公告)号：US11433629B2

公开(公告)日：2022-09-06

申请号：US16429776

申请日：2019-06-03

Applicant: Alcon Inc.

Inventor： Weihong Lang ,  Wei Liang ,  Ying Zheng ,  Karen Belinda Sentell ,  Richard Charles Breitkopf ,  Daqing Wu ,  Steve Yun Zhang

IPC: B29D11/00 ,  G02B1/04 ,  B29K83/00 ,  B29K105/00

Abstract: The invention provides a contact lens manufacturing method for cast-molding of silicone hydrogel contact lenses having enhanced oxygen permeability without adversely affecting desirable lens mechanical properties (e.g., modulus). A method of the invention comprises adding a small amount of a radical scavenger (e.g., H-TEMPO) in a polymerizable composition for cast-molding of SiHy contact lenses) to provide the resultant polymerizable composition with a bi-phase curing profile at a curing temperature of from about 45° C. to about 100° C. With such a bi-phase curing profile, the resultant polymerizable composition can be thermally cured at the curing temperature to form a SiHy contact lens having an oxygen permeability higher than that for a polymerizable composition having the substantially identical composition excepting being free of any radical scavenger.

公开(公告)号：US11439661B2

公开(公告)日：2022-09-13

申请号：US16911833

申请日：2020-06-25

Applicant: ALCON INC.

Inventor： Steve Yun Zhang ,  Richard Charles Breitkopf ,  Daqing Wu ,  Junhao Ge ,  Maria F. Gubitosi Raspino ,  Augustine Twum Kumi ,  Wei Liang

IPC: A61K31/80 ,  A61P27/04 ,  A61K31/015 ,  A61K31/07 ,  A61K31/122 ,  A61K31/202 ,  A61K31/355 ,  A61K31/593 ,  A61K31/736 ,  A61K45/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

Abstract: The invention is generally related to topical ophthalmic compositions comprising: from about 0.05 w/v % to about 5 w/v % of galactomannan polymer; a cis-diol and about 0.5 w/v % to about 10 w/v % of a hydrophilic copolymer which comprises (a) arylborono-containing repeating units each having a boronic acid, (b) repeating units of at least one phosphorylcholine-containing vinylic monomer, and (c) acrylic monomeric units of at least one acrylic monomer having 3 to 16 carbon atoms, the ophthalmic composition is substantially free of a borate for improving lubrication, hydration and drug delivery property.

公开(公告)号：US20210302625A1

公开(公告)日：2021-09-30

申请号：US17205169

申请日：2021-03-18

Applicant: Alcon Inc.

Inventor： Jing Cheng ,  Wei Liang ,  Steve Yun Zhang

IPC: G02B1/04 ,  C08G77/06 ,  C08G77/32 ,  C08J3/24

Abstract: The invention is generally related to an insert for being embedded in a silicone hydrogel contact lens. The insert is made of a crosslinked materials which are rigid in dry state at room temperature (from about 22° C. to about 26° C.), have a high oxygen permeability and a high refractive index in fully hydrated state, and can become softer at a temperature great than 32° C. Such materials are useful for making inserts in embedded contact lenses for correcting corneal astigmatism, presbyopia, and color blindness lenses and for imparting photochromic characteristics to the lenses. The invention is also related to a method for making embedded silicone hydrogel contact lenses comprising an insert of the invention therein and to embedded silicone hydrogel contact lenses comprising an insert of the invention therein.

公开(公告)号：US11867874B2

公开(公告)日：2024-01-09

申请号：US17205169

申请日：2021-03-18

Applicant: Alcon Inc.

Inventor： Jing Cheng ,  Wei Liang ,  Steve Yun Zhang

IPC: G02B1/04 ,  C08G77/06 ,  C08G77/32 ,  C08J3/24

CPC classification number: G02B1/043 ,  C08G77/06 ,  C08G77/32 ,  C08J3/246 ,  C08G2210/00 ,  C08G2270/00 ,  C08J2383/04 ,  C08J2433/08

Abstract: The invention is generally related to an insert for being embedded in a silicone hydrogel contact lens. The insert is made of a crosslinked materials which are rigid in dry state at room temperature (from about 22° C. to about 26° C.), have a high oxygen permeability and a high refractive index in fully hydrated state, and can become softer at a temperature great than 32° C. Such materials are useful for making inserts in embedded contact lenses for correcting corneal astigmatism, presbyopia, and color blindness lenses and for imparting photochromic characteristics to the lenses. The invention is also related to a method for making embedded silicone hydrogel contact lenses comprising an insert of the invention therein and to embedded silicone hydrogel contact lenses comprising an insert of the invention therein.