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    NUCLEIC ACIDS, AND USES THEROF
    23.
    发明申请
    NUCLEIC ACIDS, AND USES THEROF 审中-公开

    公开(公告)号：US20170240901A1

    公开(公告)日：2017-08-24

    申请号：US15121742

    申请日：2015-02-26

    Applicant: The University of Liverpool

    Inventor： John Hunt ,  John Innes

    IPC: C12N15/113 ,  A61K31/713 ,  A61K9/50

    CPC classification number: C12N15/1136 ,  A61K9/5031 ,  A61K31/713 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2320/32

    Abstract: Provided are siRNA molecules that are particularly efficient in their ability to reduce transcription and expression of TNF or IL-1β in canine macrophage and synovial cells. The siRNA molecules demonstrate improved silencing of TNF or IL-1β as compared to siRNA molecules disclosed prior to the present invention. These properties are demonstrated in accepted experimental models of osteoarthritis, and particularly canine osteoarthritis. The siRNA molecules of the invention, may be employed in pharmaceutical compositions for use in the prevention and/or reduction of osteoarthritis in dogs. The inventors have found that encapsulation of the siRNAs in small PLGA microspheres confers surprisingly advantageous properties.

    DEVICE FOR COMPRESSING THE UTERUS
    24.
    发明申请
    DEVICE FOR COMPRESSING THE UTERUS 审中-公开
    用于压缩UTERUS的装置

    公开(公告)号：US20170071630A1

    公开(公告)日：2017-03-16

    申请号：US15125318

    申请日：2015-03-12

    Applicant: The University of Liverpool

    Inventor： Andrew Weeks ,  John Porter

    IPC: A61B17/42 ,  A61B90/00 ,  A61B17/12

    CPC classification number: A61B17/4241 ,  A61B17/12 ,  A61B90/06 ,  A61B2017/12004 ,  A61B2090/065

    Abstract: A device for applying a compressive force to the uterus, the device comprising a contact portion for contacting the uterus and providing a compressive force thereto, and at least two elongate handles each extending from the contact portion along a respective longitudinal axis. The at least two elongate handles are configured to facilitate insertion of the device into the body and handling of the device from outside the body when inserted. At least a part of the contact portion is configured to be radially moveable relative to the longitudinal axes between a first radial position and a second radial position where the second radial position is radially outward of the first radial position.

    Abstract translation: 一种用于向子宫施加压缩力的装置，该装置包括用于接触子宫并向其提供压缩力的接触部分，以及至少两个细长手柄，每个细长手柄沿着相应的纵向轴线从接触部分延伸。 所述至少两个细长把手构造成便于将装置插入身体并且在插入时从身体的外部处理装置。 接触部分的至少一部分被配置为相对于第一径向位置和第二径向位置之间的纵向轴线径向移动，其中第二径向位置在第一径向位置的径向外侧。

    PHARMACOLOGICALLY ACTIVE COMPOUNDS
    25.
    发明申请
    PHARMACOLOGICALLY ACTIVE COMPOUNDS 有权
    药物活性化合物

    公开(公告)号：US20160318947A1

    公开(公告)日：2016-11-03

    申请号：US15107653

    申请日：2014-12-23

    Applicant: THE UNIVERSITY OF LIVERPOOL

    Inventor： Martin Leuwer ,  Paul O'Neill ,  Neil Berry ,  Chandrakala Pidathala

    IPC: C07D491/107 ,  C07D211/06 ,  C07D205/04 ,  C07D295/192 ,  C07D265/30

    CPC classification number: C07D491/107 ,  C07D205/04 ,  C07D211/06 ,  C07D265/30 ,  C07D295/192 ,  C07D493/10

    Abstract: The present invention relates to compounds of formula I shown below: wherein Q is as defined herein. The compounds of formula I act as selective positive allosteric modulators of strychnine-sensitive alpha 1-glycine receptors. The present invention further relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of diseases or conditions in which strychnine-sensitive alpha 1-glycine receptor activity is implicated (such as, for example, chronic pain. The present invention also relates to processes for the preparation of these compounds and to pharmaceutical compositions comprising them.

    Abstract translation: 其中Q如本文所定义。 式I的化合物作为士的宁敏感的α1-甘氨酸受体的选择性正变构调节剂。 本发明还涉及这些化合物作为治疗和/或预防涉及士的宁敏感性α1-甘氨酸受体活性的疾病或病症（例如慢性疼痛）的治疗剂的用途。本发明 本发明还涉及制备这些化合物的方法以及包含它们的药物组合物。

    CATALYST COMPOUNDS
    29.
    发明申请
    CATALYST COMPOUNDS 有权
    催化剂化合物

    公开(公告)号：US20150080592A1

    公开(公告)日：2015-03-19

    申请号：US14394239

    申请日：2013-04-15

    Applicant: THE UNIVERSITY OF LIVERPOOL

    Inventor： Dinesh Talwar ,  Weijun Tang ,  Chao Wang ,  Barbara Villa Marcos ,  Jianliang Xiao

    IPC: C07F15/00 ,  B01J31/22

    CPC classification number: C07F15/0033 ,  B01J31/1805 ,  B01J31/2295 ,  B01J2231/641 ,  B01J2231/643 ,  B01J2531/827 ,  C07B31/00 ,  C07F17/02

    Abstract: The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.

    Abstract translation: 本发明涉及用于氢化可还原部分，特别是亚胺和亚胺的铱基催化剂化合物，催化剂化合物由下式定义：其中环B本身为多环，或环B与R为多环。 本发明的催化剂在还原胺化方法10中特别有效，其涉及在还原氢化条件下原位生成亚胺或亚胺。

    Dyes and Uses Thereof
    30.
    发明申请
    Dyes and Uses Thereof 有权

    公开(公告)号：US20250052744A1

    公开(公告)日：2025-02-13

    申请号：US18722913

    申请日：2022-12-23

    Applicant: The University of Liverpool

    Inventor： Srijan Jindal

    IPC: G01N33/53 ,  C09K11/06 ,  G01N33/569

    Abstract: The present invention relates to a combination of fluorescent dyes for identifying, or differentiating between, different bacterial strains, wherein the combination comprises two or more of the following fluorescent dyes: SYBR Green I, SYTO 13 or 9, and/or DiSC3(5) and/or FM4-64. The device is particularly suited for identifying the type of bacterial infection causing a Urinary Tract Infection (UTI) and can be used to help identify which antimicrobial agents would be suitable for the treatment the infection.

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