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公开(公告)号：US20150073165A1
公开(公告)日：2015-03-12
申请号：US14394246
申请日：2013-04-15
Applicant: THE UNIVERSITY OF LIVERPOOL
Inventor： Barbara Villa Marcos , Weijun Tang , Dinesh Talwar , Chao Wang , Jianjun Wu , Jianliang Xiao
CPC classification number: C07F15/0033 , B01J31/18 , B01J31/2295 , B01J2231/641 , B01J2231/643 , B01J2531/827 , C07B31/00 , C07F17/02
Abstract: The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formula: (Formula (I)) where ring B is a conjugated ring system with one or more substituents. The catalysts of the invention are particularly effective in reductive amination procedures which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.
Abstract translation: 本发明涉及用于氢化可还原部分，特别是亚胺和亚胺的铱基催化剂化合物，催化剂化合物由式（I（I））定义，其中环B是具有一个或多个取代基的共轭环系。 本发明的催化剂在还原胺化方法中特别有效，其涉及在还原氢化条件下原位产生亚胺或亚胺。
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公开(公告)号：US09981957B2
公开(公告)日：2018-05-29
申请号：US15128829
申请日：2015-03-24
Applicant: THE UNIVERSITY OF LIVERPOOL
Inventor： Jianliang Xiao , Jianjun Wu
IPC: C07D409/04 , C07D211/14 , C07D211/22 , C07D211/18 , C07D211/28 , C07D211/32 , C07D211/26 , C07D405/04 , C07D211/34 , C07D401/04
CPC classification number: C07D409/04 , C07B2200/13 , C07D211/02 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/28 , C07D211/32 , C07D211/34 , C07D401/04 , C07D405/04
Abstract: The present invention relates to a process for preparing substituted piperidine compounds and especially chiral substituted piperidine compounds. The process involves reacting a substituted pyridinium ion with an amine as defined herein, in the presence of a hydrogen donor, a catalysts and a suitable solvent.
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公开(公告)号：US09212199B2
公开(公告)日：2015-12-15
申请号：US14394239
申请日：2013-04-15
Applicant: THE UNIVERSITY OF LIVERPOOL
Inventor： Dinesh Talwar , Weijun Tang , Chao Wang , Barbara Villa Marcos , Jianliang Xiao
CPC classification number: C07F15/0033 , B01J31/1805 , B01J31/2295 , B01J2231/641 , B01J2231/643 , B01J2531/827 , C07B31/00 , C07F17/02
Abstract: The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.
Abstract translation: 本发明涉及用于氢化可还原部分，特别是亚胺和亚胺的铱基催化剂化合物，催化剂化合物由下式定义：其中环B本身为多环，或环B与R为多环。 本发明的催化剂在还原胺化方法10中特别有效，其涉及在还原氢化条件下原位生成亚胺或亚胺。
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公开(公告)号：US20150080592A1
公开(公告)日：2015-03-19
申请号：US14394239
申请日：2013-04-15
Applicant: THE UNIVERSITY OF LIVERPOOL
Inventor： Dinesh Talwar , Weijun Tang , Chao Wang , Barbara Villa Marcos , Jianliang Xiao
CPC classification number: C07F15/0033 , B01J31/1805 , B01J31/2295 , B01J2231/641 , B01J2231/643 , B01J2531/827 , C07B31/00 , C07F17/02
Abstract: The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.
Abstract translation: 本发明涉及用于氢化可还原部分，特别是亚胺和亚胺的铱基催化剂化合物，催化剂化合物由下式定义：其中环B本身为多环，或环B与R为多环。 本发明的催化剂在还原胺化方法10中特别有效，其涉及在还原氢化条件下原位生成亚胺或亚胺。
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