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公开(公告)号：US20150283303A1
公开(公告)日：2015-10-08
申请号：US14438583
申请日：2013-10-29
申请人： Scripps Health
CPC分类号： A61L27/44 , A61L27/26 , A61L27/3817 , A61L27/3821 , A61L27/54 , A61L2300/412 , A61L2300/64 , A61L2430/02 , A61L2430/06 , C08L5/08 , C08L89/06
摘要： Provided are tri-component matrices having collagen, hyaluronan, and chondroitin sulfate. Also provided are processes for producing a tri-component matrix. Additionally, provided are processes for providing cells capable of producing cartilage to a bone or cartilage defects.
摘要翻译： 提供具有胶原，透明质酸和硫酸软骨素的三组分基质。 还提供了用于生产三组分基质的方法。 另外，提供了提供能够产生软骨到骨骼或软骨缺陷的细胞的方法。
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公开(公告)号：US20230233058A1
公开(公告)日：2023-07-27
申请号：US18045377
申请日：2022-10-10
申请人： SCRIPPS HEALTH
IPC分类号： A61B1/00 , A61L27/02 , A61L27/20 , A61M5/142 , A61F2/30 , B33Y10/00 , A61F2/08 , C12N5/077 , A61L27/24 , A61L27/36 , A61B90/00 , B33Y70/00 , A61B34/30 , B29C64/112 , A61M5/20 , A61B17/00
CPC分类号： A61B1/00009 , A61B1/00 , A61B34/30 , A61B90/00 , A61F2/0805 , A61F2/0811 , A61F2/3094 , A61F2/30756 , A61L27/20 , A61L27/24 , A61L27/025 , A61L27/3604 , A61L27/3608 , A61L27/3612 , A61M5/20 , A61M5/14212 , B29C64/112 , B33Y10/00 , B33Y70/00 , C12N5/0654 , C12N5/0655 , A61B2017/00969 , A61B2090/395 , A61F2002/30962 , A61L2430/06
摘要： Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.
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公开(公告)号：US10724005B2
公开(公告)日：2020-07-28
申请号：US14431893
申请日：2013-09-27
申请人： Scripps Health, Inc.
摘要： Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.
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公开(公告)号：US10385318B2
公开(公告)日：2019-08-20
申请号：US15872577
申请日：2018-01-16
申请人： Scripps Health
IPC分类号： C12N5/00 , C12N5/074 , A61K35/32 , A61K35/545
摘要： Disclosed herein are methods of producing induced pluripotent stem cells from chondrocytes, and further, methods of producing chondrocytes from said induced pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.
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公开(公告)号：US10376332B2
公开(公告)日：2019-08-13
申请号：US15056855
申请日：2016-02-29
申请人： Scripps Health
IPC分类号： A61F2/46 , A61B34/20 , A61B90/00 , A61B5/103 , A61B5/107 , A61B5/00 , A61B34/00 , A61B17/16 , A61F2/38
摘要： A joint replacement balancing system which provides real-time feedback to a surgeon during a joint replacement surgery to assist the surgeon to balance a joint replacement. The joint replacement balancing system includes a non-transitory processor-readable medium storing code representing instructions to cause a processor to receive a signal from a joint balancing apparatus, determine if the joint replacement is out of balance, determine a corrective course of action to bring the joint into balance and generate and display to the surgeon during the joint replacement surgery a recommended corrective course of action to complete the joint replacement surgery.
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公开(公告)号：US20190143000A1
公开(公告)日：2019-05-16
申请号：US16213790
申请日：2018-12-07
申请人： Scripps Health
摘要： Provided are tri-component matrices having collagen, hyaluronan, and chondroitin sulfate. Also provided are processes for producing a tri-component matrix. Additionally, provided are processes for providing cells capable of producing cartilage to a bone or cartilage defects.
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公开(公告)号：US20180291456A1
公开(公告)日：2018-10-11
申请号：US16007853
申请日：2018-06-13
发明人： Eric J. TOPOL , Evan MUSE , Mark CONNELLY , Timothy JATKOE , Haiying WANG
IPC分类号： C12Q1/6883 , G06F19/20
CPC分类号： C12Q1/6883 , C12Q2600/158 , G16B25/00
摘要： Compositions, systems and methods for the diagnosing the risk of acute myocardial infarction are provided. The methods described herein relate to the use of biomarkers, such as gene expression profiles, and analytical tools for providing information to a health care provider or the patient, that is relevant to the cardiovascular health of the patient.
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公开(公告)号：US20180155694A1
公开(公告)日：2018-06-07
申请号：US15872577
申请日：2018-01-16
申请人： Scripps Health
IPC分类号： C12N5/074 , A61K35/545 , A61K35/32
CPC分类号： C12N5/0696 , A61K35/32 , A61K35/545 , C12N2501/15 , C12N2501/155 , C12N2501/385 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/13 , C12N2510/00 , C12N2513/00 , C12N2533/54
摘要： Disclosed herein are methods of producing induced pluripotent stem cells from chondrocytes, and further, methods of producing chondrocytes from said induced pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.
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公开(公告)号：US20150259648A1
公开(公告)日：2015-09-17
申请号：US14431893
申请日：2013-09-27
申请人： SCRIPPS HEALTH
CPC分类号： C12N5/0655 , A61K35/32 , C12N2501/15 , C12N2506/02 , C12N2533/54 , C12N2533/90 , C12N2537/10
摘要： Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.
摘要翻译： 本文公开了从多能干细胞产生软骨细胞的方法。 本发明还提供了再生软骨组织的方法。
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公开(公告)号：US11859210B2
公开(公告)日：2024-01-02
申请号：US16894738
申请日：2020-06-05
申请人： Scripps Health
CPC分类号： C12N5/0655 , A61K35/32 , C12N2501/15 , C12N2506/02 , C12N2533/54 , C12N2533/90 , C12N2537/10
摘要： Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.
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