-
公开(公告)号：US20150275181A1
公开(公告)日：2015-10-01
申请号：US14438581
申请日：2013-10-29
申请人： SCRIPPS HEALTH
CPC分类号： C12N5/0696 , A61K35/32 , A61K35/545 , C12N2501/15 , C12N2501/155 , C12N2501/385 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/13 , C12N2510/00 , C12N2513/00 , C12N2533/54
摘要： Disclosed herein are methods of producing induced pluripotent stem cells from chondrocytes, and further, methods of producing chondrocytes from said induced pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.
摘要翻译： 本文公开了从软骨细胞产生诱导性多能干细胞的方法，以及从所述诱导的多能干细胞产生软骨细胞的方法。 本发明还提供了再生软骨组织的方法。
-
公开(公告)号：US11369465B2
公开(公告)日：2022-06-28
申请号：US14759398
申请日：2014-01-14
申请人： Scripps Health
发明人： Darryl D. D'Lima , Clifford Colwell
IPC分类号： A61F2/02 , A61K47/14 , A61F2/06 , A61K35/32 , A61K35/33 , C12M1/26 , C12M3/00 , A61F2/08 , A61F2/28
摘要： Methods of printing a bio-ink on a substrate are provided comprising at least one bio ink layer, said method comprising: i) positioning a printhead comprising a two-dimensional array of print nozzles within proximity of or in contact with a substrate; and ii) ejecting a bio-ink through the print nozzles onto the substrate, forming a bio ink layer, wherein the bio-ink construct comprises at least one bio-ink layer. The methods further encompass methods of printing a live tissue and methods of treating tissue defects.
-
公开(公告)号：US20200299648A1
公开(公告)日：2020-09-24
申请号：US16894738
申请日：2020-06-05
申请人： Scripps Health
摘要： Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.
-
公开(公告)号：US20150283303A1
公开(公告)日：2015-10-08
申请号：US14438583
申请日：2013-10-29
申请人： Scripps Health
CPC分类号： A61L27/44 , A61L27/26 , A61L27/3817 , A61L27/3821 , A61L27/54 , A61L2300/412 , A61L2300/64 , A61L2430/02 , A61L2430/06 , C08L5/08 , C08L89/06
摘要： Provided are tri-component matrices having collagen, hyaluronan, and chondroitin sulfate. Also provided are processes for producing a tri-component matrix. Additionally, provided are processes for providing cells capable of producing cartilage to a bone or cartilage defects.
摘要翻译： 提供具有胶原，透明质酸和硫酸软骨素的三组分基质。 还提供了用于生产三组分基质的方法。 另外，提供了提供能够产生软骨到骨骼或软骨缺陷的细胞的方法。
-
公开(公告)号：US10724005B2
公开(公告)日：2020-07-28
申请号：US14431893
申请日：2013-09-27
申请人： Scripps Health, Inc.
摘要： Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.
-
公开(公告)号：US10385318B2
公开(公告)日：2019-08-20
申请号：US15872577
申请日：2018-01-16
申请人： Scripps Health
IPC分类号： C12N5/00 , C12N5/074 , A61K35/32 , A61K35/545
摘要： Disclosed herein are methods of producing induced pluripotent stem cells from chondrocytes, and further, methods of producing chondrocytes from said induced pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.
-
公开(公告)号：US20150259648A1
公开(公告)日：2015-09-17
申请号：US14431893
申请日：2013-09-27
申请人： SCRIPPS HEALTH
CPC分类号： C12N5/0655 , A61K35/32 , C12N2501/15 , C12N2506/02 , C12N2533/54 , C12N2533/90 , C12N2537/10
摘要： Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.
摘要翻译： 本文公开了从多能干细胞产生软骨细胞的方法。 本发明还提供了再生软骨组织的方法。
-
公开(公告)号：US11859210B2
公开(公告)日：2024-01-02
申请号：US16894738
申请日：2020-06-05
申请人： Scripps Health
CPC分类号： C12N5/0655 , A61K35/32 , C12N2501/15 , C12N2506/02 , C12N2533/54 , C12N2533/90 , C12N2537/10
摘要： Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.
-
公开(公告)号：US11497831B2
公开(公告)日：2022-11-15
申请号：US16304618
申请日：2017-05-25
申请人： Scripps Health
IPC分类号： A61L27/20 , A61B34/30 , A61B1/00 , A61L27/36 , A61L27/02 , A61L27/24 , A61M5/142 , A61F2/30 , B29C64/112 , B33Y70/00 , A61B90/00 , B33Y10/00 , A61M5/20 , A61F2/08 , C12N5/077 , A61B17/00
摘要： Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.
-
公开(公告)号：US11497830B2
公开(公告)日：2022-11-15
申请号：US15125749
申请日：2015-03-13
申请人： Scripps Health
IPC分类号： A61F2/38 , A61L27/26 , A61F2/30 , A61L27/20 , A61L27/24 , A61L27/54 , A61L27/52 , A61L27/50 , A61L27/38 , A61L27/18 , A61L27/58 , D01D5/00 , D01D5/34 , A61F2/44
摘要： Disclosed herein are methods of producing a cartilaginous implant by producing a polymer scaffold composition by electrospinning a polymer solution onto a collector in order to obtain polymer fibers; crosslinking the polymer fibers; and adding a plurality of cells to the polymer scaffold composition, wherein the plurality of cells comprises cartilaginous cells to form a cartilaginous implant.
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.016 秒)
