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公开(公告)号:US20030044833A1
公开(公告)日:2003-03-06
申请号:US10233419
申请日:2002-09-04
Applicant: Randox Laboratories Ltd.
IPC: C12Q001/68 , B05D003/00 , G01N033/53 , G01N033/542 , C12M001/34
CPC classification number: G01N33/54353 , G01N33/54393 , G01N33/551
Abstract: Multi-analyte microarrays are produced by first attaching to the surface of a solid support, a silane with an electrophilic terminal group, contacting the terminal group with a polyamine, and activating the polyamine with an electrophilic, bifunctional linker.
Abstract translation: 多分析物微阵列通过首先附着到固体支持物的表面,具有亲电子端基的硅烷,与末端基团与多胺接触,并用亲电子双功能连接体活化多胺来制备。
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公开(公告)号:US20020086337A1
公开(公告)日:2002-07-04
申请号:US09949756
申请日:2001-09-12
Applicant: RANDOX LABORATORIES LTD.
Inventor: Stephen Peter Fitzgerald , John Victor Lamont , Robert Ivan McConnell
IPC: G01N033/53 , G01N033/542 , G01N033/536
CPC classification number: G01N33/94 , G01N33/54306
Abstract: An assay for an analyte in a sample, wherein the sample is contacted with an array of ligands including a ligand specific for the analyte, additionally comprises including a scavenger material that binds the analyte and thereby reduces its available concentration.
Abstract translation: 样品中分析物的分析物,其中样品与包括对分析物特异性的配体的配体阵列接触,另外包括包含结合分析物的清除剂材料,从而降低其可用浓度。
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公开(公告)号:US20020058319A1
公开(公告)日:2002-05-16
申请号:US09949757
申请日:2001-09-12
Applicant: RANDOX LABORATORIES LTD.
Inventor: Stephen Peter Fitzgerald , John Campbell , John Victor Lamont , Marlene King
IPC: C12N009/96 , A61K038/54
CPC classification number: C12N9/0065 , C12N9/0006 , C12N9/96
Abstract: A method for stabilizing an enzyme during freezing, wherein the enzyme is in a zwitterionic buffer solution. The zwitterionic buffer is able to maintain the activity of the enzyme during freezing and thawing.
Abstract translation: 一种用于在冷冻期间稳定酶的方法,其中所述酶在两性离子缓冲溶液中。 两性离子缓冲液能够在冷冻和解冻期间保持酶的活性。
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公开(公告)号:US20240310400A1
公开(公告)日:2024-09-19
申请号:US18576835
申请日:2022-07-08
Applicant: RANDOX LABORATORIES LTD.
Inventor: James DAVIDSON , Ivan MCCONNELL , Peter FITZGERALD
CPC classification number: G01N35/1011 , G01N1/14 , G01N35/00732 , G01N2035/00277 , G01N2035/0405
Abstract: There is provided an apparatus and method for extracting a biological sample from a sample container. The apparatus comprising: a holder arranged in use to support a sample container; an extractor moveable in use between a first position disengaged from the container when the container is supported by the holder and a second position engaged with the container when the container is supported by the holder, the extractor being arranged in use to obtain matter from the container when in the second position; and an imager arranged in use to capture an image of the extractor at the first position when the extractor is moved from the second position to the first position and to identify, based on analysis of the captured image, when sample is present outside the container.
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公开(公告)号:US20240296539A1
公开(公告)日:2024-09-05
申请号:US18572687
申请日:2022-07-01
Applicant: Randox Laboratories Ltd.
Inventor: Deepesh UPADHYAY , Peter FITZGERALD , Ivan MCCONNELL
IPC: G06T7/00 , H04N23/56 , H04N23/695
CPC classification number: G06T7/0004 , H04N23/56 , H04N23/695 , G06T2207/30072
Abstract: There is provided a vision system for assessing defects on biochips and a corresponding method. The vision system comprises an imaging region in which a biochip sheet including at least one biochip is locatable in use: an imager arranged in use to image at least a portion of the imaging region, wherein, when the biochip sheet is located in the imaging region. the portion includes at least a face of the biochip sheet: and an illumination source arranged in use to direct illumination on to the face the biochip sheet. thereby illuminating defects on the at least one biochip when a mask material layer is present on the at least one biochip and when a mask material is absent and allowing the defects to be included in the imaged at least a portion of the imaging region.
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公开(公告)号:US20240168038A1
公开(公告)日:2024-05-23
申请号:US18283652
申请日:2022-03-25
Applicant: RANDOX LABORATORIES , RANDOX TEORANTA
Inventor: Ivan McConnell , Peter Fitzgerald , John Lamont , Ciaran Richarson , Matthew Griffin
IPC: G01N33/68
CPC classification number: G01N33/6893 , G01N2333/4716 , G01N2333/70578 , G01N2800/347 , G01N2800/52
Abstract: The current invention provides methods which can be implemented alongside clinical variables as risk prediction tools for improved prediction of CKD progression and mortality. Surprisingly it was found that decreased C3a-desArg was associated with adverse outcome in CKD, and when combined with increased STNFR1 and NGAL it gave an excellent predictor of progression to a composite endpoint in CKD patients.
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公开(公告)号:US11988607B2
公开(公告)日:2024-05-21
申请号:US16632270
申请日:2018-07-18
Applicant: Randox Laboratories Ltd
Inventor: Marc Wharry , P. Evans , Stuart Jackson
CPC classification number: G01N21/76 , B01L3/50855 , B01L2200/02 , B01L2200/0689
Abstract: There is provided a chemiluminescence detector sample enclosure. The enclosure comprises a first interface member forming part of a chemiluminescence detector and having a first sealing element and a second interface member comprising a plurality of sample holders, each sample holder having a second sealing element. The first interface member is engagable with and moveable between sample holder subsets of the plurality of sample holders, engagement with a respective sample holder subset providing engagement of the first interface member with each sample holder of the respective sample holder subset and relative movement of the first and second interface members providing movement between sample holder subsets; and when the first interface member is engaged with each respective sample holder, the first sealing element and the respective second sealing element are adapted to interact so as to form a light restricting seal between the first interface member and said sample holder.
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公开(公告)号:US20230406933A1
公开(公告)日:2023-12-21
申请号:US18035070
申请日:2021-11-02
Applicant: Randox Laboratories Ltd.
Inventor: Marshall Dunlop , Shirley Schon , John Lamont , Peter Fitzgerald
IPC: C07K16/28
CPC classification number: C07K16/2827 , C07K2317/622 , C07K2317/92 , C07K2317/33 , C07K2317/22 , C07K2317/94 , C07K2317/76
Abstract: The present invention relates to therapeutic antibodies, or antigen-binding portions thereof, for use in the treatment of cancer and infectious disease. Specifically, the present invention relates to therapeutic antibodies, or antigen-binding portions thereof, that target the programmed death-ligand 1 polypeptide. The present invention also relates to pharmaceutical compositions comprising said therapeutic antibody, or antigen-binding portions thereof.
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公开(公告)号:US11623214B2
公开(公告)日:2023-04-11
申请号:US16772593
申请日:2018-12-07
Applicant: Randox Laboratories Ltd
Inventor: Stuart Jackson
IPC: B01L3/00
Abstract: A fluidic card assembly (1) comprises an inlet (20) for introducing a fluid to the fluidic card assembly (1), a turbulent flow portion (30) downstream of the inlet (20), the turbulent flow portion (30) comprising a widening fluid channel (31) whereby a fluid introduced via the inlet (20) channel undergoes turbulence, and a laminar flow portion (40) downstream of the turbulent flow portion (30). The laminar flow portion (40) is configured to allow fluid passing from the turbulent flow portion (30) into the laminar flow portion (40) to establish a laminar flow pattern, and is configured to house a biochip (44) such that a fluid in the laminar flow portion (40) may be in contact with the biochip (44).
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公开(公告)号:US20220412994A1
公开(公告)日:2022-12-29
申请号:US17775217
申请日:2020-11-06
Applicant: Randox Laboratories Ltd
Inventor: Paul Innocenzi , Mark Ruddock , John Lamont , Peter Fitzgerald
IPC: G01N33/68
Abstract: Described is the use of GFAP as a marker of drug-induced cellular toxicity and depression.
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