公开(公告)号：US20190154672A1

公开(公告)日：2019-05-23

申请号：US16313316

申请日：2017-06-30

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Ivan McConnell ,  Peter Fitzgerald ,  John Lamont ,  Ciaran Richardson

IPC: G01N33/543 ,  G01N33/92 ,  C07K16/18

Abstract: The present invention relates to a multiplexing system comprising a support substrate having immobilised thereto one or more of the following proteins, fragments thereof or a binding molecule, wherein the binding molecule binds specifically to one of the following proteins: E-FABP, B-FABP, IL-FABP, I-FABP, M-FABP, A-FABP, H-FABP, L-FABP or T-FABP. Another aspect is directed to a method for characterising the pattern of FABP antigens existing within a biological sample to reveal information useful in the diagnosis or disease or injury.

公开(公告)号：US20190247820A1

公开(公告)日：2019-08-15

申请号：US16388527

申请日：2019-04-18

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  John Lamont ,  Ivan McConnell ,  Elouard Benchikh ,  Deepesh Upadhyay ,  Ciaran Richardson

IPC: B01J19/00 ,  C12M1/00 ,  G01N33/543 ,  C09D11/102 ,  C09D11/03

CPC classification number: B01J19/0046 ,  B01J2219/00608 ,  B01J2219/00637 ,  C09D11/03 ,  C09D11/102 ,  C12M1/00 ,  G01N33/54393

Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

公开(公告)号：US10279332B2

公开(公告)日：2019-05-07

申请号：US15983484

申请日：2018-05-18

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  John Lamont ,  Ivan McConnell ,  Elouard Benchikh ,  Deepesh Upadhyay ,  Ciaran Richardson

IPC: B01J19/00 ,  C09D11/03 ,  C09D11/102 ,  C12M1/00 ,  G01N33/543

Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

公开(公告)号：US20180339282A1

公开(公告)日：2018-11-29

申请号：US15983484

申请日：2018-05-18

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  John Lamont ,  Ivan McConnell ,  Elouard Benchikh ,  Deepesh Upadhyay ,  Ciaran Richardson

IPC: B01J19/00 ,  C09D11/03 ,  C09D11/102 ,  C12M1/00

CPC classification number: B01J19/0046 ,  B01J2219/00608 ,  B01J2219/00637 ,  C09D11/03 ,  C09D11/102 ,  C12M1/00 ,  G01N33/54393

Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

公开(公告)号：US20240168038A1

公开(公告)日：2024-05-23

申请号：US18283652

申请日：2022-03-25

Applicant: RANDOX LABORATORIES ,  RANDOX TEORANTA

Inventor： Ivan McConnell ,  Peter Fitzgerald ,  John Lamont ,  Ciaran Richarson ,  Matthew Griffin

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2333/4716 ,  G01N2333/70578 ,  G01N2800/347 ,  G01N2800/52

Abstract: The current invention provides methods which can be implemented alongside clinical variables as risk prediction tools for improved prediction of CKD progression and mortality. Surprisingly it was found that decreased C3a-desArg was associated with adverse outcome in CKD, and when combined with increased STNFR1 and NGAL it gave an excellent predictor of progression to a composite endpoint in CKD patients.

公开(公告)号：US20220341943A1

公开(公告)日：2022-10-27

申请号：US17765383

申请日：2020-10-07

Applicant: Randox Laboratories Ltd ,  Randox Teoranta

Inventor： Ivan McConnell ,  Peter Fitzgerald ,  Ciaran Richardson ,  Kenneth Martin

IPC: G01N33/68 ,  G01N33/50 ,  G01N33/543

Abstract: Methods, devices and kits for the detection and quantification of XBP1s and XBP1u are described.

公开(公告)号：US11467163B2

公开(公告)日：2022-10-11

申请号：US16065646

申请日：2016-12-23

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Ivan McConnell ,  Peter Fitzgerald ,  John Lamont ,  Ciaran Richardson

IPC: G01N33/574

Abstract: The present invention describes methods of determining the glycosylation signature and determining the level of a protein in a sample obtained from a patient.
The present invention also describes use of a patient protein glycosylation profile to identify the presence or absence of a disease in subjects.

公开(公告)号：US11383216B2

公开(公告)日：2022-07-12

申请号：US16424330

申请日：2019-05-28

Applicant: Randox Laboratories Ltd. ,  Randox Teoranta

Inventor： Peter Fitzgerald ,  John Lamont ,  Ivan McConnell ,  Elouard Benchikh ,  Deepesh Upadhyay ,  Ciaran Richardson

IPC: B01J19/00 ,  C09D11/102 ,  C09D11/03 ,  G01N33/543 ,  C12M1/00

Abstract: A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

公开(公告)号：US20240201178A1

公开(公告)日：2024-06-20

申请号：US18284783

申请日：2022-03-31

Applicant: RANDOX LABORATORIES LTD. ,  RANDOX TEORANTA

Inventor： Peter Fitzgerald ,  John Victor Lamont ,  Ivan McConnell ,  Ciaran Richardson ,  Philip Lowry ,  Jim Curry

IPC: G01N33/543 ,  G01N33/68

CPC classification number: G01N33/54353 ,  G01N33/54393 ,  G01N33/6857 ,  G01N2650/00

Abstract: The present invention relates to improved detection assays via the utilisation of a substrate with an analyte immobilised on its surface by means of a linking agent and a cross-linker. The present invention also relates to a method of producing a substrate for use in detection assays and a method of detecting an analyte using said substrate.

公开(公告)号：US20240091783A1

公开(公告)日：2024-03-21

申请号：US18273737

申请日：2022-01-21

Applicant: RANDOX LABORATORIES LTD ,  Randox Teoranta

Inventor： Dale Love ,  Peter Fitzgerald ,  Ivan McConnell ,  Christina McFadden

IPC: B01L9/00

CPC classification number: B01L9/523 ,  B01L2200/025

Abstract: There is provided a bracket for a biological sample analyser. The bracket comprises abase and an arm extending from the base, the base being engageable with a platform of a biological sample analyser, wherein, when the base is engaged with the platform, the arm extends into a sample plate bay of the biological sample analyser prohibiting access to a portion of the bay. The arm thereby limits misalignment of a sample plate in the bay by blocking access to a portion of the bay only required when the sample plate is loaded into the bay in an incorrect orientation. A biological sample analyser comprising a bay in which a sample plate is loadable in use and the bracket is also provided.