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448 条记录 (耗时 0.049 秒)

    Catheter probe arrangement for tissue analysis by radiant energy delivery and radiant energy collection
    21.
    发明授权
    Catheter probe arrangement for tissue analysis by radiant energy delivery and radiant energy collection 有权

    公开(公告)号：US08386023B2

    公开(公告)日：2013-02-26

    申请号：US13084418

    申请日：2011-04-11

    申请人： Simon M. Furnish

    发明人： Simon M. Furnish

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0075

    摘要： A catheter tip apparatus arranged in a catheter for the delivery and collection of a light-energy signal to permit subsequent computerized analysis of body tissue by the collected signal. The apparatus comprises an elongated housing supporting a first reflective surface and a second reflective surface. The first reflective surface and the second reflective surface are longitudinally spaced apart from one another. A first flexible, elongated energy bearing delivery fiber has a distalmost end arranged adjacent the first reflective surface. A second flexible, elongated energy bearing collection fiber has a distalmost end arranged adjacent the second reflective surface. The housing is rotatably supported on a flexible catheter sheath for insertion of the catheter into a mammalian body for tissue analysis thereof.

    Method for introducing a fluid into a reaction receptacle contained within a temperature-controlled environment
    23.
    发明授权
    Method for introducing a fluid into a reaction receptacle contained within a temperature-controlled environment 有权
    将流体引入包含在温度受控环境中的反应容器中的方法

    公开(公告)号：US08309358B2

    公开(公告)日：2012-11-13

    申请号：US11928219

    申请日：2007-10-30

    申请人： Kelly G. Ammann ,  Robert E. Schneider ,  Robert J. Smith

    发明人： Kelly G. Ammann ,  Robert E. Schneider ,  Robert J. Smith

    IPC分类号： G01N35/02

    CPC分类号： B01L7/5255 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  G01N35/0098 ,  G01N35/0099 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/25 ,  Y10T436/2575

    摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

    摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品的台站，在规定温度下培养样品规定的时间，进行分析物分离程序，并确定目标分析物的存在。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。

    Live finger detection by four-point measurement of complex impedance
    28.
    发明授权
    Live finger detection by four-point measurement of complex impedance 有权
    用手指检测四点测量复阻抗

    公开(公告)号：US08195285B2

    公开(公告)日：2012-06-05

    申请号：US12961007

    申请日：2010-12-06

    申请人： Orjan G. Martinsen ,  Jon Nysaether ,  Knut Riisnaes ,  Ingvild Juvkam Dyve, legal representative ,  Geir Mostad ,  Rune Pedersen ,  Nicolai W. Christie ,  Sigmund Clausen

    发明人： Orjan G. Martinsen ,  Jon Nysaether ,  Knut Riisnaes ,  Geir Mostad ,  Rune Pedersen ,  Nicolai W. Christie ,  Sigmund Clausen

    IPC分类号： A61B5/05 ,  G06T1/00 ,  G06T7/00

    CPC分类号： A61B5/6826 ,  A61B5/0531 ,  A61B5/442 ,  A61B5/6838 ,  G06K9/0002 ,  G06K9/00899

    摘要： A method and sensor assembly for determining the condition of a structure, especially for confirming if a measured fingerprint is on a live finger, measures characteristics of close to the structure surface. The sensor includes a first pair of current supply electrodes coupled to a current source, providing an electrical current to the skin, at least two pickup electrodes at chosen and different positions relative to the current supply electrodes, at least a first of the pickup electrodes being coupled to an instrument for measuring the voltage between the first pickup electrode and at least one of the pickup or current supply electrodes, storage for a predetermined set of values characterizing a certain condition of the surface, and means for comparing the characteristics from each pickup electrode with the measurements of the other pickup electrodes and with the predetermined set of characteristics for determining the surface condition.

    摘要翻译： 用于确定结构状况的方法和传感器组件，特别是用于确认测量的指纹是否在活的手指上，测量靠近结构表面的特性。 传感器包括耦合到电流源的第一对电流供应电极，相对于电流供应电极在选定和不同位置处向皮肤提供电流，至少两个拾取电极，至少第一个拾取电极为 耦合到用于测量第一拾取电极和拾取或供电电极中的至少一个之间的电压的仪器，用于存储表征表面的一定条件的预定值的值，以及用于比较来自每个拾取电极的特性的装置 具有其他拾取电极的测量值以及用于确定表面状态的预定的一组特性。

    Fluorescent membrane intercalating probes and methods for their use
    29.
    发明授权
    Fluorescent membrane intercalating probes and methods for their use 有权
    荧光膜插入探针及其使用方法

    公开(公告)号：US08029767B2

    公开(公告)日：2011-10-04

    申请号：US12330073

    申请日：2008-12-08

    申请人： Brian D. Gray

    发明人： Brian D. Gray

    IPC分类号： A61B10/00 ,  A61B5/00

    CPC分类号： A61K49/0032 ,  C07D209/14 ,  C07D209/60 ,  C07D215/12

    摘要： The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably possess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well retained therein. Methods of using the dyes to detect stained cells both in vivo and in vitro are also disclosed.

    摘要翻译： 本发明涉及一系列花青染料，其在远红和近红外波长的光谱下发荧光，并且优选具有亲脂侧链。 本发明的染料可溶于市售的膜染色载体，可用作快速染色亲脂性结构如细胞中的膜或从细胞分离的探针，并且很好地保留在其中。 还公开了使用染料在体内和体外检测染色细胞的方法。

    Factor risk model based system, method, and computer program product for generating risk forecasts
    30.
    发明授权
    Factor risk model based system, method, and computer program product for generating risk forecasts 有权
    基于风险模型的系统，方法和计算机程序产品，用于生成风险预测

    公开(公告)号：US08019670B2

    公开(公告)日：2011-09-13

    申请号：US12830017

    申请日：2010-07-02

    申请人： Ananth Madhavan ,  Artem V. Asriev ,  Scott J. Kartinen ,  Jian Yang ,  Vitaly Serbin ,  Ian Domowitz ,  Kenneth E. Gosier

    发明人： Ananth Madhavan ,  Artem V. Asriev ,  Scott J. Kartinen ,  Jian Yang ,  Vitaly Serbin ,  Ian Domowitz ,  Kenneth E. Gosier

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/08 ,  G06Q10/087 ,  G06Q40/00 ,  G06Q40/025 ,  G06Q40/06

    摘要： A computerized method for generating risk forecasts is provided. A set of securities is selected. A set of risk factors is selected. The risk factor returns a determined. A risk factor covariance matrix and an idiosyncratic variance matrix are constructed. For each risk factor, a factor loading coefficient is determined for each selected security. The risk factor covariance matrix is projected into a future forecast. The idiosyncratic variance matrix is projected into a future forecast. The factor loading coefficients, the future forecast of the risk factor covariance matrix, and the future forecast of the idiosyncratic variance matrix can be used to determine a forecast of the variance-covariance matrix for the selected securities.

    摘要翻译： 提供了一种用于生成风险预测的计算机化方法。 选择一组证券。 选择一组风险因素。 风险因素返回确定。 构建风险因子协方差矩阵和特征方差矩阵。 对于每个风险因素，为每个选定的证券确定因子负荷系数。 风险因子协方差矩阵被预测为未来的预测。 特殊方差矩阵预测为未来预测。 因子加载系数，风险因子协方差矩阵的未来预测以及特殊方差矩阵的未来预测可用于确定所选证券的方差 - 协方差矩阵的预测。