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    Drug Release From Nanoparticle-Coated Capsules
    7.
    发明申请
    Drug Release From Nanoparticle-Coated Capsules 审中-公开
    纳米颗粒涂层胶囊释放药物

    公开(公告)号：US20110229559A1

    公开(公告)日：2011-09-22

    申请号：US13073351

    申请日：2011-03-28

    申请人： Clive Allan Prestidge ,  Spomenka Simovic ,  Nasrin Ghouchi Eskandar

    发明人： Clive Allan Prestidge ,  Spomenka Simovic ,  Nasrin Ghouchi Eskandar

    IPC分类号： A61K9/127 ,  A61K9/00 ,  A61K31/07 ,  A61P3/02 ,  B82Y5/00

    CPC分类号： A61K9/1075 ,  A61K9/5115

    摘要： Methods of producing a controlled release formulation for an active substance are disclosed, wherein the methods involve dispersing a discontinuous phase comprising an active substance into a continuous phase so as to form a two-phase liquid system comprising droplets of said discontinuous phase, and allowing nanoparticles provided to the two-phase liquid system to congregate at the phase interface to thereby coat the surface of the droplets in at least one layer of said nanoparticles. The methods utilise a concentration of a suitable electrolyte which enhances the nanoparticle congregation such that the coating of nanoparticles on the surface of the droplets presents a semi-permeable barrier to the active substance, or otherwise utilise a amount of the active substance that is greater than the solubility limit of that active substance in the discontinous phase. Formulations comprising vitamin A (retinol) as the active substance for dermal delivery are specifically exemplified.

    摘要翻译： 公开了制备用于活性物质的控制释放制剂的方法，其中所述方法包括将包含活性物质的不连续相分散到连续相中以形成包含所述不连续相的液滴的两相液体体系，并且允许纳米颗粒 提供给两相液体系统以聚集在相界面处，从而在至少一层所述纳米颗粒中涂覆液滴的表面。 该方法利用浓度合适的电解质，其增强了纳米颗粒聚集，使得在液滴表面上的纳米颗粒的涂层呈现出对活性物质的半透性屏障，或者另外使用一定量的活性物质大于 该活性物质在不连续相中的溶解度极限。 具体地列举包含维生素A（视黄醇）作为真皮递送活性物质的制剂。

    Drug Release From Nanoparticle-Coated Capsules
    8.
    发明申请
    Drug Release From Nanoparticle-Coated Capsules 审中-公开
    纳米颗粒涂层胶囊释放药物

    公开(公告)号：US20090181076A1

    公开(公告)日：2009-07-16

    申请号：US12299063

    申请日：2007-05-04

    申请人： Clive Allan Prestidge ,  Spomenka Simovic ,  Nasrin Ghouchi Eskandar

    发明人： Clive Allan Prestidge ,  Spomenka Simovic ,  Nasrin Ghouchi Eskandar

    IPC分类号： A61K9/127 ,  A61K9/14 ,  A61K31/07 ,  A61P3/00

    CPC分类号： A61K9/1075 ,  A61K9/5115

    摘要： Methods of producing a controlled release formulation for an active substance are disclosed, wherein the methods involve dispersing a discontinuous phase comprising an active substance into a continuous phase so as to form a two-phase liquid system comprising droplets of said discontinuous phase, and allowing nanoparticles provided to the two-phase liquid system to congregate at the phase interface to thereby coat the surface of the droplets in at least one layer of said nanoparticles. The methods utilise a concentration of a suitable electrolyte which enhances the nanoparticle congregation such that the coating of nanoparticles on the surface of the droplets presents a semi-permeable barrier to the active substance, or otherwise utilise a amount of the active substance that is greater than the solubility limit of that active substance in the discontinous phase. Formulations comprising vitamin A (retinol) as the active substance for dermal delivery are specifically exemplified.

    摘要翻译： 公开了制备用于活性物质的控制释放制剂的方法，其中所述方法包括将包含活性物质的不连续相分散到连续相中以形成包含所述不连续相的液滴的两相液体体系，并且允许纳米颗粒 提供给两相液体系统以聚集在相界面处，从而在至少一层所述纳米颗粒中涂覆液滴的表面。 该方法利用浓度合适的电解质，其增强了纳米颗粒聚集，使得在液滴表面上的纳米颗粒的涂层呈现出对活性物质的半透性屏障，或者另外使用一定量的活性物质大于 该活性物质在不连续相中的溶解度极限。 具体地列举包含维生素A（视黄醇）作为真皮递送活性物质的制剂。