公开(公告)号：US07847112B2

公开(公告)日：2010-12-07

申请号：US10569036

申请日：2004-07-16

Applicant: Narayana Rao Mantripragada ,  Dhananjay Govind Sathe ,  Venkatasubramanian Radhakrishnan Tarur ,  Kamlesh Digambar Sawant ,  Gautam Ramjibhai Patel

Inventor： Narayana Rao Mantripragada ,  Dhananjay Govind Sathe ,  Venkatasubramanian Radhakrishnan Tarur ,  Kamlesh Digambar Sawant ,  Gautam Ramjibhai Patel

IPC: C07C50/00 ,  A61K31/12 ,  A01N35/00

CPC classification number: C07C50/32 ,  C07C46/10

Abstract: Novel crystalline forms of anti Pneumocystis carinii compound (2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone) commonly known as Atovaquone and methods for producing the same is disclosed herein. This also provides pharmaceutical compositions comprising the said polymorphs of Atovaquone and method of treating Pneumocystis carinii pneumonia, the method comprising administering to a warm blooded animal an effective amount of a product-by-process composition of matter comprising polymorphic forms of Atovaquone.

Abstract translation: 通常称为Atovaquone的抗卡氏肺囊虫化合物（2- [4-（4-氯苯基）环己基] -3-羟基-1,4-萘醌）的新型结晶形式及其制备方法公开。 这也提供了包含所述Atovaquone多晶型物和治疗卡氏肺囊虫肺炎的方法的药物组合物，该方法包括向温血动物施用有效量的包含多佐型酮的多形态物质的逐步产物组合物。

公开(公告)号：US20080093985A1

公开(公告)日：2008-04-24

申请号：US11693306

申请日：2007-03-29

Applicant: Hironobu MORISHITA ,  Hisayuki Kawamura ,  Chishio Hosokawa

Inventor： Hironobu MORISHITA ,  Hisayuki Kawamura ,  Chishio Hosokawa

IPC: H01L51/54 ,  C09K11/06 ,  C07C43/00 ,  C07C50/00

CPC classification number: C07C50/28 ,  C07C46/00 ,  C07C49/755 ,  C07C50/32 ,  C07C211/54 ,  C07C255/37 ,  C07C261/04 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  H01L51/0051 ,  H01L51/0052 ,  H01L51/0059 ,  H01L51/0081 ,  H01L51/5048 ,  H01L51/5092 ,  H05B33/14

Abstract: A material for an organic electroluminescent device including a quinone derivative represented by the following formula (1), (2) or (3): wherein R1 to R16 are each a hydrogen atom, a halogen atom, a cyano group, an alkoxy group, a substituted or unsubstituted aryloxy group, an alkyl group, a fluoroalkyl group, an aryl group or a heterocyclic group; provided that at least one of R1 to R4, at least one of R5 to R10 or at least one of R11 to R16 is an aryloxy group; and X is a substituent represented by any one of the following formulas (a) to (f): wherein R17 to R19 are a hydrogen atom, an alkyl group, or aryl group; and R18 and R19 may be bonded together to form a ring.

Abstract translation: 包含由下式（1），（2）或（3）表示的醌衍生物的有机电致发光器件的材料：其中R 1至R 16各自为 氢原子，卤素原子，氰基，烷氧基，取代或未取代的芳氧基，烷基，氟代烷基，芳基或杂环基; 或者R 1至R 4中的至少一个，R 5至R 10中的至少一个或R 10 R 11至R 16中的至少一个为芳氧基; 并且X是由下式（a）至（f）中的任一个表示的取代基：其中R 17至R 19为氢原子，烷基， 或芳基; 并且R 18和R 19可以结合在一起形成环。

公开(公告)号：US5180742A

公开(公告)日：1993-01-19

申请号：US1893

申请日：1987-01-09

Applicant: Shinji Terao ,  Yoshitaka Maki

Inventor： Shinji Terao ,  Yoshitaka Maki

IPC: A61K31/12 ,  A61K31/047 ,  A61K31/122 ,  A61K31/16 ,  A61K31/19 ,  A61K31/215 ,  A61K31/38 ,  A61K31/381 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/14 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C39/11 ,  C07C45/29 ,  C07C46/00 ,  C07C46/02 ,  C07C46/06 ,  C07C47/277 ,  C07C50/00 ,  C07C50/04 ,  C07C50/06 ,  C07C50/08 ,  C07C50/14 ,  C07C50/28 ,  C07C50/30 ,  C07C50/32 ,  C07C59/86 ,  C07C59/90 ,  C07C66/00 ,  C07C69/145 ,  C07C69/734 ,  C07C69/92 ,  C07C259/10 ,  C07C271/12 ,  C07D333/22 ,  C07D333/24 ,  C07D333/38 ,  C07D521/00

CPC classification number: C07D249/08 ,  C07C45/29 ,  C07C46/00 ,  C07C46/02 ,  C07C46/06 ,  C07C47/277 ,  C07C50/06 ,  C07C50/08 ,  C07C50/28 ,  C07C50/30 ,  C07C50/32 ,  C07C66/00 ,  C07D231/12 ,  C07D233/56 ,  C07D333/22 ,  C07D333/24

Abstract: Quinone derivatives of the general formula: ##STR1## (wherein R.sup.1 and R.sup.2 are the same or different, and independently are a hydrogen atom or a methyl or methoxy group, or R.sup.1 and R.sup.2 combine with each other to represent --CH.dbd.CH--CH.dbd.CH--R.sup.3 is a hydrogen atom or a methyl group; R.sup.4 is an aliphatic, aromatic or heterocyclic group which may be substituted; R.sup.5 is a methyl or methoxy group, a hydroxymethyl group which may be substituted or a carboxyl group which may be esterified or amidated; Z is a group represented by --C.dbd.C--, --CH.dbd.CH--, ##STR2## n is an integer of 0 to 10; m is an integer of 0 to 3; k is an integer of 0 to 5, provided, however, that in the case of m being 2 or 3, Z and k can vary arbitrarily within the bracketed repeating units) are novel compounds, possess metabolism ameliorating action for polyunsaturated fatty acids, particularly production inhibitory activity of lipid peroxides (antioxidant activity), thromboxane A.sub.2 receptor antagonism, or production inhibitory activity of 5-lipoxygenase metabolites in mammals, and of use as drugs, such as antiasthmatic, antiallergic agent and cerebral-circulatory metabolism ameliorating agent.

Abstract translation: 喹啉酮衍生物，其通式为：其中R 1和R 2相同或不同，独立地为氢原子或甲基或甲氧基，或者R 1和R 2彼此结合，表示-CH = CH-CH = CH-R 3是氢原子或甲基; R 4是可以被取代的脂族，芳族或杂环基; R 5是甲基或甲氧基，可被取代的羟甲基或羧基， 可以被酯化或酰胺化; Z是由-C = C-，-CH = CH-，表示的基团，n是0至10的整数; m是0至3的整数; k是 但是在m为2或3的情况下，Z和k可以在括号内的重复单元内任意变化）为新化合物，具有对多不饱和脂肪酸的代谢改善作用，特别是生产抑制作用 脂质过氧化物的活性（抗氧化活性），血栓素A2受体拮抗作用或产生抑制活性 y的5-脂氧合酶代谢物在哺乳动物中，并用作药物，如止喘，抗过敏药和脑循环代谢改善剂。

公开(公告)号：US4577019A

公开(公告)日：1986-03-18

申请号：US518769

申请日：1983-08-02

Applicant: Enrico Bruschi

Inventor： Enrico Bruschi

IPC: A23K1/16 ,  A61K31/12 ,  C07C45/00 ,  C07C50/00 ,  C07C67/00 ,  C07C301/00 ,  C07D213/80 ,  C07D213/82 ,  C07D473/34

CPC classification number: C07D213/80 ,  A23K20/174 ,  A61K31/12 ,  C07D213/82

Abstract: Stabilized adducts of K vitaminic compounds, as menadione bisulfite or a derivative thereof and stabilizing vitamins as, particularly, nicotine amide or nicotinic acid. Feed compositions containing the same. Process for their preparation.

Abstract translation: K维生素化合物的稳定加合物，如亚硫酸甲萘酯或其衍生物，并稳定维生素，特别是尼古丁酰胺或烟酸。 含有它的饲料组合物。 其准备过程

公开(公告)号：US4510089A

公开(公告)日：1985-04-09

申请号：US386790

申请日：1982-06-08

Applicant: Shu Hotta ,  Tomiharu Hosaka ,  Wataru Shimotsuma

Inventor： Shu Hotta ,  Tomiharu Hosaka ,  Wataru Shimotsuma

IPC: C07C255/32 ,  C07C255/45 ,  C08K5/315 ,  C09B1/00 ,  H01B1/12 ,  H01L51/30 ,  C07C50/00

CPC classification number: H01B1/121 ,  C07C255/00 ,  C08K5/315 ,  C09B1/00 ,  H01L51/0051

Abstract: 1,2,3,4,5,6,7,8-Octahydro-11,11,12,12-tetracyano-9,10-anthraquinodimethane compounds of the general formula ##STR1## in which W, X, Y and Z independently represent hydrogen, halogen, hydroxyl group, hydrocarbon group having 1 to 8 carbon atoms, alkoxy group or acyloxy group provided that W=Y and X=Z, or W=Z and X=Y. The compositions and charge transfer complexes comprising these compounds are also described together with intermediates for the compounds.

Abstract translation: 1,2,3,4,5,6,7,8-八氢-11,11,12,12-四氰基-9,10-蒽醌二甲醚化合物，其中W，X，Y和 Z独立地表示氢，卤素，羟基，碳原子数为1〜8的烃基，烷氧基或酰氧基，只要W = Y，X = Z，或W = Z，X = Y。 包含这些化合物的组合物和电荷转移络合物也与化合物的中间体一起描述。

公开(公告)号：US4362668A

公开(公告)日：1982-12-07

申请号：US62333

申请日：1979-07-31

Applicant: Richard J. Lee

Inventor： Richard J. Lee

IPC: A01N35/06 ,  C07C46/00 ,  C07C46/06 ,  C07C50/08 ,  C07F9/6571 ,  C08F8/06 ,  C09K15/06 ,  C07C50/00

CPC classification number: C09K15/06 ,  A01N35/06 ,  C07C46/00 ,  C07C46/06 ,  C07C50/08 ,  C07F9/657127 ,  C08G65/34 ,  C08G65/38 ,  C08G65/44

Abstract: Ortho-quinones with alkyl, olefin polymer, or halogen substituents and a process for the preparation of these compounds comprising a base catalyzed halogen oxidation of alkylated phenol.

Abstract translation: 具有烷基，烯烃聚合物或卤素取代基的正 - 醌和用于制备这些化合物的方法包括烷基化苯酚的碱催化卤素氧化。

公开(公告)号：US20210395906A1

公开(公告)日：2021-12-23

申请号：US17410135

申请日：2021-08-24

Applicant: CustomArray, Inc.

Inventor： Karl Maurer ,  John J. Cooper, JR.

IPC: C25B3/00 ,  C25B3/23 ,  C07D213/16 ,  C07C50/04 ,  B01J19/00 ,  C07B31/00 ,  C07C50/00 ,  C07C309/30 ,  C07H21/02 ,  C07B41/02 ,  C07C39/08 ,  C25B3/25 ,  C07B33/00 ,  C07H21/04 ,  C25B3/29 ,  C07B41/06

Abstract: There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.

公开(公告)号：US08187346B2

公开(公告)日：2012-05-29

申请号：US12345567

申请日：2008-12-29

Applicant: James R. Butler

Inventor： James R. Butler

IPC: C10L1/18 ,  C07C50/00

CPC classification number: C10G55/04 ,  C10G29/20 ,  C10G29/22 ,  C10G2300/104 ,  C10L1/1857 ,  C10L1/2222

Abstract: A method for stabilizing pyrolysis gasoline in storage involves adding an effective amount of a quinone methide compound to the pyrolysis gasoline. The quinone methide does not require oxygen for activity. Embodiments of the quinone methide do not contain nitrogen and will have a reduced tendency for ammonia production.

Abstract translation: 在储存中稳定裂解汽油的方法包括向热解汽油中加入有效量的醌甲基化合物。 醌甲基化物质不需要氧气用于活性。 醌甲基化物的实施方案不含有氮并且具有降低的氨生产倾向。

公开(公告)号：US4831265A

公开(公告)日：1989-05-16

申请号：US33864

申请日：1987-04-03

Applicant: Masazumi Watanabe ,  Isuke Imada

Inventor： Masazumi Watanabe ,  Isuke Imada

IPC: C07C50/00 ,  C07C43/205 ,  C07C43/23 ,  C07C45/00 ,  C07C46/00 ,  C07C46/06 ,  C07C50/28 ,  C07C67/00 ,  C07C69/14 ,  C07C409/34

CPC classification number: C07C50/28 ,  C07C43/2055 ,  C07C43/23 ,  C07C46/00

Abstract: A quinone compound of the formula: ##STR1## wherein R stands for an alkyl group of 1 to 22 carbon atoms having at its terminal end a hydroxyl group which may be protected, can be obtained with industrial advantage by allowing a compound of the formula: ##STR2## to react with a peroxide of a carboxylic acid of the formula:RCOOHwherein R is as defined above, or with a peroxide of an acid anhydride of the carboxylic acid. The quinone compound wherein R stands for an alkyl group of 1 to 2 carbon atoms having at its terminal end an optionally protected hydroxyl group, is a novel compound and has antifibrotic activity.

Abstract translation: 其中R代表具有1至22个碳原子的烷基，其末端可被保护的羟基的醌化合物可通过工业上的优点得到，通过使下式化合物： 与下式的羧酸的过氧化物反应：其中R如上定义，或与羧酸的酸酐的过氧化物反应。 其中R代表具有1至2个碳原子的烷基的醌化合物在其末端具有任选保护的羟基，是新化合物并具有抗纤维化活性。

公开(公告)号：US4797357A

公开(公告)日：1989-01-10

申请号：US868479

申请日：1986-05-30

Applicant: Albert J. Mura ,  Paul B. Merkel

Inventor： Albert J. Mura ,  Paul B. Merkel

IPC: C12Q1/04 ,  G01N21/00 ,  G01N21/76 ,  G01N33/52 ,  G01N33/533 ,  C07C50/00

CPC classification number: G01N33/52 ,  C12Q1/04 ,  G01N33/533 ,  C12Q2304/26 ,  Y10S436/80 ,  Y10S436/805 ,  Y10S436/807 ,  Y10S436/904

Abstract: Certain reducible aromatic and quinone compounds having bulky groups on the carbamate nitrogen atom have improved stability to light. These compounds are useful in analytical compositions, elements and methods, e.g. for assays of bacterial cells. These compounds have suitable substituents that promote the release of phenalenone or benzphenalenone fluorescent dyes at physiological pH.

Abstract translation: 在氨基甲酸氮原子上具有大体积基团的某些可还原的芳族和醌化合物具有改善的光稳定性。 这些化合物可用于分析组合物，元素和方法，例如 用于细菌细胞的测定。 这些化合物具有合适的取代基，其在生理pH下促进phenalenone或benzphenalenone荧光染料的释放。