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    Quinone derivatives, their production and use
    4.
    发明授权
    Quinone derivatives, their production and use 失效
    喹诺酮衍生物，其生产和使用

    公开(公告)号：US5304658A

    公开(公告)日：1994-04-19

    申请号：US923598

    申请日：1992-08-03

    Applicant: Shinji Terao ,  Yoshitaka Maki

    Inventor： Shinji Terao ,  Yoshitaka Maki

    IPC: A61C15/02 ,  C07C50/02 ,  C07C50/10

    CPC classification number: A61C15/02

    Abstract: Quinone derivatives of the general formula: ##STR1## (wherein R.sup.1 and R.sup.2 are the same or different, and independently are a hydrogen atom or a methyl or methoxy group, or R.sup.1 and R.sup.2 combine with each other to represent --CH.dbd.CH--CH.dbd.CH--; R.sup.3 is a hydrogen atom or a methyl group; R.sup.4 is an aliphatic, aromatic or heterocyclic group which may be substituted; R.sup.5 is a methyl or methoxy group, a hydroxymethyl group which may be substituted or a carboxyl group which may be esterified or amidated; Z is a group represented by --C.tbd.C--, --CH.dbd.CH--, ##STR2## n is an integer of 0 to 10; m is an integer of 0 to 3; k is an integer of 0 to 5, provided, however, that in the case of m being 2 or 3, Z and k can vary arbitrarily within the bracketed repeating units) are novel compounds, possess metabolism ameliorating action for polyunsaturate fatty acids, particularly production inhibitory activity of lipid peroxides (antioxidant activity), thromboxane A.sub.2 receptor antagonism, or production inhibitory activity of 5-lipoxygenase metabolites in mammals, and of use as drugs, such as antiasthmatic, antiallergic agent and cerebral-circulatory metabolism ameliorating agent.

    Abstract translation: 喹啉酮衍生物，其通式为：其中R 1和R 2相同或不同，独立地为氢原子或甲基或甲氧基，或者R 1和R 2彼此结合，表示-CH = CH-CH = CH-; R3为氢原子或甲基; R4为可被取代的脂肪族，芳香族或杂环基; R5为甲基或甲氧基，可被取代的羟甲基或羧基 其可以被酯化或酰胺化; Z是由-C 3BOND C - ， - CH = CH-表示的基团，n是0至10的整数; m是0至3的整数; k 是0〜5的整数，但m为2或3的情况下，Z和k可以在括号内的重复单元内任意变化）为新型化合物，具有促进多不饱和脂肪酸代谢改善的作用，特别是生产 脂质过氧化物的抑制活性（抗氧化活性），血栓素A2受体拮抗作用或产生抑制作用 哺乳动物中5-脂氧合酶代谢物的活性，以及​​用作药物，如抗哮喘药，抗过敏药和脑循环代谢改善剂。

    Coumaran derivatives and their pharmaceutical use
    6.
    发明授权
    Coumaran derivatives and their pharmaceutical use 失效
    香豆素衍生物及其药物用途

    公开(公告)号：US4857516A

    公开(公告)日：1989-08-15

    申请号：US136273

    申请日：1987-12-22

    Applicant: Shinji Terao ,  Yoshitaka Maki

    Inventor： Shinji Terao ,  Yoshitaka Maki

    IPC: C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D307/94 ,  C07D405/04

    CPC classification number: C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D307/94 ,  C07D405/04

    Abstract: A compound of the formula ##STR1## wherein R is a lower alkyl group, R.sup.0 is hydrogen or an acyl group, R.sup.1 and R.sup.2 are lower alkyl groups which may optionally be substituted or wherein R.sup.1 and R.sup.2 are combined to form a butadienylene group which may optionally be substituted, R.sup.3 and R.sup.4 are hydrogen or alkyl groups which may optionally be substituted or wherein R.sup.3 and R.sup.4 are combined to form a polymethylene group, and R.sup.5 is a lower alkyl, aromatic or heterocyclic group which may optionally be substituted or a pharmaceutically acceptable salt thereof, exerts cardiovascular system improving action and antiallergic action and can be used as pharmaceutics, e.g. antithromotics, antiallergic agents etc.

    Abstract translation: 式（I）的化合物，其中R是低级烷基，R 0是氢或酰基，R 1和R 2是可任意被取代的低级烷基，或其中R 1和R 2结合形成丁二烯基 可以任选被取代的基团，R 3和R 4是氢或可以任选被取代的烷基，或者其中R 3和R 4结合形成多亚甲基，R 5是可任意被取代的低级烷基，芳族或杂环基， 其药学上可接受的盐发挥心血管系统改善作用和抗过敏作用，可用作药物，例如， 抗血栓药，抗过敏剂等

    5-pyridyl-1,3-thiazole derivatives
    7.
    发明授权
    5-pyridyl-1,3-thiazole derivatives 失效
    5-吡啶基-1,3-噻唑衍生物

    公开(公告)号：US4612321A

    公开(公告)日：1986-09-16

    申请号：US647436

    申请日：1984-09-05

    Applicant: Shinji Terao ,  Yoshitaka Maki

    Inventor： Shinji Terao ,  Yoshitaka Maki

    IPC: C07D417/04 ,  C07D417/14 ,  C07D405/14 ,  A61K31/44

    CPC classification number: C07D417/04 ,  C07D417/14

    Abstract: Novel compounds of the formula: ##STR1## wherein R.sup.1 stands for an optionally substituted alkyl group, alkenyl group, aryl group, aralkyl group, cycloalkyl group, heterocyclic group having carbon as the bonding hand or amino group, R.sup.2 stands for a pyridyl group which may be substituted with alkyl group, and R.sup.3 stands for an optionally substituted aryl group or salts thereof, have analgesic, anti-piretic, anti-inflammatory and anti-ulcer actions, and can be administered to mammals for the therapy of pain, inflammatory diseases, rheumatic chronic diseases.

    Abstract translation: 下式的新型化合物：其中R1代表任选取代的烷基，烯基，芳基，芳烷基，环烷基，具有碳作为键合或氨基的杂环基，R2代表 可以被烷基取代的吡啶基，R3代表任意取代的芳基或其盐具有止痛，抗皮质，抗炎和抗溃疡作用，并且可以施用于哺乳动物治疗疼痛 ，炎性疾病，风湿性慢性疾病。

    Quinone derivatives, their production and use
    8.
    发明授权
    Quinone derivatives, their production and use 失效
    喹诺酮衍生物，其生产和使用

    公开(公告)号：US5229385A

    公开(公告)日：1993-07-20

    申请号：US818856

    申请日：1992-01-10

    Applicant: Shinji Terao ,  Kohei Nishikawa

    Inventor： Shinji Terao ,  Kohei Nishikawa

    IPC: C07D213/50 ,  C07D213/55 ,  C07D409/06 ,  C07D521/00

    CPC classification number: C07D231/12 ,  C07D213/50 ,  C07D213/55 ,  C07D233/56 ,  C07D249/08 ,  C07D409/06

    Abstract: Quinone derivatives represented by the general formula ##STR1## (wherein, R.sup.1 and R.sup.2, the same or different, refer to hydrogen atom, methyl or methoxymethyl group, or R.sup.1 and R.sup.2 bind together to form --CH.dbd.CH--CH.dbd.CH--; R.sup.3 is hydrogen atom or methyl group; R.sup.4 is nitrogen-containing heterocyclic group which may be substituted; R.sup.5 is hydrogen atom, methyl group, hydroxymethyl group which may be substituted, or carboxyl group which may be esterified or amidated; Z is ##STR2## (wherein, R' is hydrogen atom or methyl group); n is an integer from 0 through 12, m is an integer from 0 through 3, and k is an integer from 0 through 7, providing that, when m is 2 or 3, Z and k are able to vary appropriately in the repeating unit shown in []), and the hydroquinone derivatives thereof, are novel compounds, possess improvement effects of metabolism of poly unsaturated fatty acids, particularly two or more of inhibition of production of fatty acid peroxides, inhibition of production of metabolites in 5-lipoxygenase pathway, inhibition of thromboxane A.sub.2 synthetase, thromboxane A.sub.2 receptor antagonism and scavenging action of active oxygen species, and of use as drugs, such as antithrombotics, anti-vascular constriction agents, anti-asthma agent, antiallergic agents, therpeutics for psoriasis, agents for improvement in heart, brain and cardiovascular systems, therapeutics for nephritis, active oxygen-eliminating agents, anticancer agents, agents for improvement of control of arachidonate cascade products, etc.

    Abstract translation: 由通式（I）表示的醌酮衍生物（其中，R1和R2相同或不同，指氢原子，甲基或甲氧基甲基，或R1和R2结合在一起形成-CH = CH-CH = CH-; R3是氢原子或甲基; R4是可以被取代的含氮杂环基; R5是氢原子，甲基，可被取代的羟甲基，或可被酯化或酰胺化的羧基; Z是 （其中，R'为氢原子或甲基）; n为0〜12的整数，m为0〜3的整数，k为0〜7的整数， 当m为2或3时，Z和k能够在[]）所示的重复单元中适当变化，并且其氢醌衍生物是新型化合物，具有改善多不饱和脂肪酸代谢的效果，特别是两种或更多种 抑制脂肪酸过氧化物的产生，抑制代谢物的产生 在5-脂氧合酶途径中，血栓烷A2合成酶的抑制，血栓素A2受体拮抗作用和活性氧的清除作用，以及用作药物，如抗血栓形成剂，抗血管收缩剂，抗哮喘药，抗过敏剂，治疗剂 牛皮癣，改善心脏，脑和心血管系统的药剂，肾炎治疗剂，活性氧消除剂，抗癌剂，改善花生四烯酸级联产物的控制剂等。

    Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines
    9.
    发明授权
    Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines 失效
    抑制3-（1-烯基）吡啶的血栓烷合成酶

    公开(公告)号：US4563446A

    公开(公告)日：1986-01-07

    申请号：US632332

    申请日：1984-07-19

    Applicant: Shinji Terao ,  Kohei Nishikawa

    Inventor： Shinji Terao ,  Kohei Nishikawa

    IPC: C07D213/02 ,  C07D213/06 ,  C07D213/16 ,  C07D213/26 ,  C07D213/30 ,  C07D213/48 ,  C07D213/55 ,  C07D213/56 ,  C07D213/57 ,  C07D213/80 ,  C07D213/89 ,  C07D401/06 ,  C07D405/02 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D521/00 ,  C07F7/18 ,  C07D213/59 ,  C07D213/24 ,  A61K31/44

    CPC classification number: C07D213/16 ,  C07D213/26 ,  C07D213/30 ,  C07D213/48 ,  C07D213/55 ,  C07D213/56 ,  C07D213/57 ,  C07D213/80 ,  C07D213/89 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D405/06 ,  C07D409/06 ,  C07F7/1856

    Abstract: Novel compounds of the formula: ##STR1## wherein R.sup.2 is an aromatic or heterocyclic group, which may optionally be substituted, R.sup.2 is a methyl group, a hydroxymethyl group, a nitroxymethyl group, a formyl group, a nitrogen-containing five-membered ring-methyl group, an acetal-methyl group, a trialkylsilyloxymethyl group, an alkyl- or aryl-sulfonyloxymethyl group, an alkyl- or aryl-sulfonylaminocarbonyloxymethyl group, an acyloxymethyl group, an alkoxycarbonyloxymethyl group, a halogenomethyl group, an alkoxymethyl group, an aryloxymethyl group, a cyano group, a carbamoyl group which may optionally be substituted, a carbamoyloxymethyl group which may optionally be substituted, a thiocarbamoyloxymethyl group which may optionally be substituted, and an alkoxycarbonyl group, n is an integer of 1 to 20, and ##STR2## provided that n is an integer of 9 to 20 when ##STR3## and, at the same time, R.sup.2 is a carboxyl group or an alkoxycarbonyl group, or a pharmacologically acceptable salt thereof, have a selective inhibitory action on biosynthesis of thromboxane A.sub.2 (TXA.sub.2) and an effect of enhancing the production of prostaglandin I.sub.2 (PGI.sub.2), and can be used for mammals to prevent and treat arterial thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardiac infarction, stroke, occlusion of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

    Abstract translation: 下式的新型化合物：其中R 2为可任意取代的芳族或杂环基，R 2为甲基，羟甲基，硝酰甲基，甲酰基，含氮五元环 甲基，缩醛 - 甲基，三烷基甲硅烷氧基甲基，烷基 - 或芳基 - 磺酰氧基甲基，烷基 - 或芳基 - 磺酰基氨基羰基氧基甲基，酰氧基甲基，烷氧基羰氧基甲基，卤代甲基，烷氧基甲基， 基团，氰基，可以任意取代的氨基甲酰基，可任意取代的氨基甲酰氧基甲基，可任意取代的硫代氨基甲酰氧基甲基，烷氧基羰基，n为1〜20的整数，＆lt; IMAGE >条件是当中n为9〜20的整数，并且同时R2为羧基或烷氧基羰基时，或其药理学上可接受的盐具有 对血栓素A2（TXA2）的生物合成的选择性抑制作用和增强前列腺素I2（PGI2）的产生的作用，可用于哺乳动物预防和治疗血小板聚集或心脏血管痉挛引起的缺血性疾病引起的动脉血栓形成 ，脑和周围循环系统（例如， 心脏梗死，中风，肾脏，肺部和其他器官中血管闭塞，果胶性溃疡等）。

    Manufacturing method of semiconductor device and semiconductor manufacturing device
    10.
    发明申请
    Manufacturing method of semiconductor device and semiconductor manufacturing device 失效
    半导体器件和半导体制造器件的制造方法

    公开(公告)号：US20060057860A1

    公开(公告)日：2006-03-16

    申请号：US11207064

    申请日：2005-08-18

    Applicant: Shinji Terao

    Inventor： Shinji Terao

    IPC: H01L21/31

    CPC classification number: H01L21/02238 ,  H01L21/02255 ,  H01L21/31662 ,  H01L21/67253

    Abstract: A manufacturing method of a semiconductor device, comprises; a process of heat-treating a semiconductor substrate under the ordinary pressure and in an oxidizing atmosphere; and a process of heat-treating the semiconductor substrate under the ordinary pressure and in an inert atmosphere, wherein heat-treating time or heat-treating temperature in heat treatment in the oxidizing atmosphere is changed based on the fluctuation of atmospheric pressure, and the heat-treating time in the inert atmosphere is determined based on the heat-treating time or the heat-treating temperature in the oxidizing atmosphere.

    Abstract translation: 一种半导体器件的制造方法，包括： 在常压和氧化气氛中对半导体衬底进行热处理的工艺; 以及在常压下和惰性气氛下对半导体基板进行热处理的工序，其中氧化气氛中的热处理时间或热处理温度根据大气压的波动而变化，热量 基于氧化气氛中的热处理时间或热处理温度来确定惰性气氛中的时间。

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