公开(公告)号：US20160062098A1

公开(公告)日：2016-03-03

申请号：US14888257

申请日：2014-05-15

Applicant: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

Inventor： Jonathon Quincy Brown

IPC: G02B21/16 ,  H04N5/225 ,  A61B10/02 ,  G06K9/52 ,  G01N1/30 ,  A61B5/00 ,  G02B21/36 ,  G06K9/62

CPC classification number: G02B21/16 ,  A61B5/0071 ,  A61B10/02 ,  A61B2090/366 ,  A61B2090/3941 ,  G01N1/30 ,  G01N21/6458 ,  G01N2001/302 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2201/0635 ,  G01N2201/0675 ,  G01N2201/129 ,  G02B21/0076 ,  G02B21/365 ,  G02B21/367 ,  G06K9/52 ,  G06K9/6267 ,  H04N5/2256

Abstract: Systems and methods are provided for evaluating a fresh tissue sample, prepared as to fluoresce under illumination, during a medical procedure. A structured light source is configured to project a spatially patterned light beam onto the fresh tissue sample. An imaging system is configured to produce an image from fluorescence emitted from the illuminated fresh tissue sample. A system control is configured to provide a human-comprehensible clinically useful output associated with the medical procedure.

Abstract translation: 提供了系统和方法，用于评估在医疗过程中制备为在照明下发荧光的新鲜组织样品。 结构化光源被配置为将空间图案化的光束投影到新鲜组织样本上。 成像系统被配置为从照亮的新鲜组织样品发射的荧光产生图像。 系统控制被配置为提供与医疗过程相关联的人类可理解的临床有用的输出。

公开(公告)号：US20160054576A1

公开(公告)日：2016-02-25

申请号：US14782005

申请日：2014-03-25

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Takashi INOUE ,  Hirotoshi TERADA

IPC: G02B27/28 ,  G02B27/09 ,  G02B5/30 ,  G02B27/00

CPC classification number: G02B27/283 ,  G01N21/6458 ,  G01N2201/0675 ,  G02B5/3016 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/0092 ,  G02B27/0025 ,  G02B27/0905

Abstract: An optical module (1A) includes a polarization beam splitter (10A) having a light splitting surface (11), polarization elements (20, 40), and respectively arranged on an optical path of a first polarization component (L2) transmitted through the light splitting surface (11) and an optical path of a second polarization component (L4) reflected by the light splitting surface (11), a reflective SLM (30) that modulates and reflects the first polarization component (L2) passing through the polarization element (20), and a reflective SLM (50) that modulates and reflects the second polarization component (L4) passing through the polarization element (40). The first modulation light (L3) passing through the polarization element (20) again and then reflected by the light splitting surface (11) and the second modulation light (L5) passing through the polarization element (40) again and then transmitted through the light splitting surface (11) are combined with each other.

Abstract translation: 光学模块（1A）包括具有光分离表面（11）的偏振分束器（10A），偏振元件（20,40），并且分别布置在透过该光的第一偏振分量（L2）的光路上 分离表面（11）和由所述光分离表面（11）反射的第二偏振分量（L4）的光路;反射SLM（30），其对通过所述偏振元件的所述第一偏振分量（L2）进行调制和反射 20），以及反射SLM（50），其对通过偏振元件（40）的第二偏振分量（L4）进行调制和反射。 再次通过偏振元件（20）的第一调制光（L3），然后再次通过分光表面（11）和第二调制光（L5）反射，然后透过该光 分离表面（11）彼此组合。

公开(公告)号：US08917395B2

公开(公告)日：2014-12-23

申请号：US13089715

申请日：2011-04-19

Applicant: Fraser Dalgleish ,  Anni Dalgleish ,  Bing Ouyang

Inventor： Fraser Dalgleish ,  Anni Dalgleish ,  Bing Ouyang

IPC: G01N21/55 ,  G01N21/47 ,  G01N21/17

CPC classification number: G01N21/47 ,  G01N2021/1793 ,  G01N2201/0675

Abstract: An imaging or sensor system comprises a transmitter assembly, a receiver assembly and a control unit. The transmitter assembly defines an outgoing optical beam transmission path with respect to a target surface and the receiver assembly defines a return optical signal transmission path from the target surface. Each of the paths includes transmission through or reflection from at least one microdisplay device comprising a plurality of controllable elements for selective placement in a transmit mode for transmission of light along the transmission paths. A control unit selectively places the microdisplay device elements in the transmission mode.

Abstract translation: 成像或传感器系统包括发射器组件，接收器组件和控制单元。 发射器组件相对于目标表面限定出射光束传输路径，并且接收器组件限定了来自目标表面的返回光信号传输路径。 每个路径包括从包括多个可控元件的至少一个微显示设备的透射或反射，用于以发射模式选择性地放置以沿着传输路径传输光。 控制单元选择性地将微显示器件元件置于传输模式中。

公开(公告)号：US20130034913A1

公开(公告)日：2013-02-07

申请号：US13648740

申请日：2012-10-10

Applicant: LEICA MICROSYSTEMS CMS GMBH

Inventor： Volker SEYFRIED ,  Werner KNEBEL

IPC: G01N21/76

CPC classification number: G02B21/0076 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2201/0675 ,  G02B21/0056 ,  G03H1/0404 ,  G03H1/08 ,  G03H1/0866

Abstract: In order to investigate a specimen (30) with the aid of a microscope (20), dye particles (40, 42) in the specimen (30) are excited to fluoresce with the aid of a first illumination light beam (24). Fluorescent light proceeding from the specimen (30) is directed via an optical arrangement (34) onto an areal sensor (36), the optical arrangement (34) acting on the fluorescent light in such a way that sub-beams of the fluorescent light interfere with themselves, so that interference patterns produced as a result of the interference are imaged on a sensitive surface of the areal sensor (36) and sensed thereby. Positions of the dye particles (40, 42) within the specimen (30) are ascertained as a function of the interference patterns.

Abstract translation: 借助于显微镜（20）研究样品（30），借助于第一照明光束（24）激发样品（30）中的染料颗粒（40,42）以发荧光。 从样品（30）进行的荧光通过光学装置（34）引导到面传感器（36）上，光学装置（34）以荧光的子光束干涉 使得由于干扰而产生的干涉图案被成像在面传感器（36）的敏感表面上并被感测。 确定样品（30）内的染料颗粒（40,42）的位置作为干涉图案的函数。

公开(公告)号：US20120182591A1

公开(公告)日：2012-07-19

申请号：US13328255

申请日：2011-12-16

Applicant: Takahiro Masumura

Inventor： Takahiro Masumura

IPC: G03H1/12 ,  G02B26/00

CPC classification number: G03H1/0443 ,  G01N21/00 ,  G01N21/4795 ,  G01N21/6456 ,  G01N2201/0675 ,  G02B21/0032 ,  G02B21/0052 ,  G02B21/0056 ,  G02B26/06 ,  G03H2001/0072 ,  G03H2001/0083 ,  G03H2001/0447 ,  G03H2001/0458 ,  G03H2001/0467

Abstract: An apparatus includes a low-coherent light source configured to emit an electromagnetic wave; a spatial light modulator configured to modulate a wavefront of the electromagnetic wave; an interferometer including a movable mirror to set a depth of a medium to be irradiated by the electromagnetic wave and a beam splitter configured to the electromagnetic wave into a reference beam and an object beam; a detector to detect information about an interference pattern formed by the object beam coming from the medium via the beam splitter and the reference beam reflected by the movable mirror; and a controller configured to control the spatial light modulator, based on the information, to form a modulated wavefront for irradiating the medium.

Abstract translation: 一种装置，包括配置成发射电磁波的低相干光源; 配置为调制所述电磁波的波前的空间光调制器; 干涉仪，包括可移动反射镜，用于设置要被电磁波照射的介质的深度;以及分配器，被配置为电磁波到参考光束和物体光束中; 检测器，用于检测由通过分束器的来自介质的物体束形成的干涉图案和由可移动镜反射的参考光束的信息; 以及控制器，其被配置为基于所述信息来控制所述空间光调制器，以形成用于照射所述介质的调制波阵面。

公开(公告)号：US20120069342A1

公开(公告)日：2012-03-22

申请号：US13089715

申请日：2011-04-19

Applicant: Fraser Dalgleish ,  Anni Dalgleish ,  Bing Ouyang

Inventor： Fraser Dalgleish ,  Anni Dalgleish ,  Bing Ouyang

IPC: G01N21/55 ,  H01L27/00

CPC classification number: G01N21/47 ,  G01N2021/1793 ,  G01N2201/0675

Abstract: An imaging or sensor system comprises a transmitter assembly, a receiver assembly and a control unit. The transmitter assembly defines an outgoing optical beam transmission path with respect to a target surface and the receiver assembly defines a return optical signal transmission path from the target surface. Each of the paths includes transmission through or reflection from at least one microdisplay device comprising a plurality of controllable elements for selective placement in a transmit mode for transmission of light along the transmission paths. A control unit selectively places the microdisplay device elements in the transmission mode.

Abstract translation: 成像或传感器系统包括发射器组件，接收器组件和控制单元。 发射器组件相对于目标表面限定出射光束传输路径，并且接收器组件限定了来自目标表面的返回光信号传输路径。 每个路径包括从包括多个可控元件的至少一个微显示设备的透射或反射，用于以发射模式选择性地放置以沿着传输路径传输光。 控制单元选择性地将微显示器件元件置于传输模式中。

公开(公告)号：US20100292931A1

公开(公告)日：2010-11-18

申请号：US12774856

申请日：2010-05-06

Applicant: Sheng Wang ,  Cheng Sun ,  Xiang Zhang

Inventor： Sheng Wang ,  Cheng Sun ,  Xiang Zhang

IPC: G06F19/00 ,  G01N21/00

CPC classification number: G01N21/6458 ,  G01N21/6408 ,  G01N2201/0627 ,  G01N2201/0675

Abstract: An optical platform and system for the simultaneous stimulation, manipulation and probing of multiple living cells in complex biological systems. The apparatus utilizes a spatiotemporal light modulator to expose a sample to pinpoints of light at selected times and wavelengths in two or three dimensional space and then detect the responses. In one embodiment, a spatiotemporal light modulator is optically coupled to a variable wavelength light source, a lens system and a system control unit with sample response sensors, wherein sample responses are detected after exposure to patterns of light in real time. Light patterns can be modulated in response to sample responses.

Abstract translation: 用于在复杂生物系统中同时刺激，操纵和探测多个活细胞的光学平台和系统。 该装置利用时空光调制器将样品暴露于两维或三维空间中选定时间和波长处的光的精确点，然后检测响应。 在一个实施例中，时空光调制器与可变波长光源，透镜系统和具有采样响应传感器的系统控制单元光学耦合，其中在曝光到实际图案之后检测样本响应。 光图案可以响应于样品响应进行调制。

公开(公告)号：US20100278399A1

公开(公告)日：2010-11-04

申请号：US12601587

申请日：2008-05-30

Applicant: Artur Bednarkiewicz ,  Maurice Whelan

Inventor： Artur Bednarkiewicz ,  Maurice Whelan

IPC: G06K9/00

CPC classification number: G01N21/6408 ,  G01N21/6458 ,  G01N2021/6423 ,  G01N2201/0675 ,  G02B21/16 ,  G02B21/365

Abstract: Method of fluorescence imaging including: illuminating a sample to excite its fluorescence and acquiring an image thereof; based on fluorescence spectral and spatial information from the sample's fluorescence image, segmenting the image into regions of similar spectral properties; for each image segment, exciting the fluorescence of the corresponding sample region, and detecting the corresponding fluorescence; based on modelling, determining expected fluorescence parameters from the fluorescence signals detected for each region; scanning the sample and determining final fluorescence parameters based on said expected fluorescence parameters.

Abstract translation: 荧光成像方法包括：照射样品以激发其荧光并获得其图像; 基于来自样品荧光图像的荧光光谱和空间信息，将图像分割成具有相似光谱性质的区域; 对于每个图像片段，激发相应样品区域的荧光，并检测相应的荧光; 基于建模，从为每个区域检测的荧光信号确定预期的荧光参数; 扫描样品并基于所述预期荧光参数确定最终荧光参数。

公开(公告)号：US20090112482A1

公开(公告)日：2009-04-30

申请号：US12258803

申请日：2008-10-27

Applicant: Perry L. Sandstrom

Inventor： Perry L. Sandstrom

IPC: G01N33/48

CPC classification number: G01N21/6452 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/6408 ,  G01N21/6428 ,  G01N2021/0346 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2201/0636 ,  G01N2201/0675

Abstract: The present invention relates to novel systems, devices, and methods comprising spatial light modulators for use in the reading and synthesis of microarrays. For example, the present invention provides micromirror systems for synthesizing and acquiring data from nucleic acid microarrays and systems for collecting, processing, and analyzing data obtained from a microarray.

Abstract translation: 本发明涉及包含用于微阵列读取和合成的空间光调制器的新型系统，装置和方法。 例如，本发明提供用于从核酸微阵列合成和获取数据的微镜系统以及用于收集，处理和分析从微阵列获得的数据的系统。

公开(公告)号：US20060012872A1

公开(公告)日：2006-01-19

申请号：US10529395

申请日：2003-09-18

Applicant: Terutake Hayashi ,  Katsuhiro Maekawa ,  Takayuki Shibata

Inventor： Terutake Hayashi ,  Katsuhiro Maekawa ,  Takayuki Shibata

IPC: G02B21/06

CPC classification number: G01N21/6458 ,  G01N21/21 ,  G01N21/6445 ,  G01N21/6452 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2201/0675 ,  G02B21/0024 ,  G02B21/0068 ,  G02B21/0076

Abstract: The present invention relates to a confocal microscope and the measuring methods of fluorescence and the polarized light using the same, and said confocal microscope is provided with the inlet optical part (10, 10′) to let the polarized light from an illuminating light source (11) onto an object to be observed (2) via a matrix type liquid crystal device (22) provided with a microlens array (21) on its top part, and an objective lens (23), the light detecting part (30, 30′) to detect the reflected or the fluorescent light from the object to be observed, and the liquid crystal control subpart (52) to control a liquid crystal device (22), and it transmits the light passing through said microlens array (21) from each microlens to each pixel (22a) of the liquid crystal device (22), and makes a plurality of foci (24) on the object to be observed (2) by the objective lens (23), as well as controls polarization directions of the lights transmitted through each pixel of the liquid crystal device (22) using the liquid crystal control subpart (52) so that they are made mutually orthogonal.

Abstract translation: 本发明涉及共焦显微镜以及使用其的荧光和偏振光的测量方法，并且所述共聚焦显微镜设置有入射光学部件（10,10'），以使来自照明光源的偏振光 11）通过在其顶部设置有微透镜阵列（21）的矩阵型液晶装置（22）和物镜（23）到待观察的物体（2）上，光检测部分（30,30） '）来检测来自被观察物体的反射光或荧光，以及液晶控制部（52）来控制液晶装置（22），将通过所述微透镜阵列（21）的光从 每个微透镜到液晶装置（22）的每个像素（22a），并且通过物镜（23）在被观察物体（2）上形成多个焦点（24），并且控制偏振方向 的光线通过每个像素传输 使用液晶控制子部（52）使液晶装置（22）相互正交。