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229 条记录 (耗时 0.038 秒)

    Method of preparing 2,6,10-Trimethyl-1,1-dialkoxy-3,5,9-undecatriene used as an intermediate of lycopene
    11.
    发明授权
    Method of preparing 2,6,10-Trimethyl-1,1-dialkoxy-3,5,9-undecatriene used as an intermediate of lycopene 有权
    制备用作番茄红素中间体的2,6,10-三甲基-1,1-二烷氧基-3,5,9-十一碳三烯的方法

    公开(公告)号：US09051254B2

    公开(公告)日：2015-06-09

    申请号：US13493971

    申请日：2012-06-11

    申请人： Pengfei Zhang ,  Chao Shen ,  Runpu Shen ,  Wei Liu ,  Chunlei Wu

    发明人： Pengfei Zhang ,  Chao Shen ,  Runpu Shen ,  Wei Liu ,  Chunlei Wu

    IPC分类号： C07C41/01 ,  C07C41/48

    CPC分类号： C07C41/48 ,  C07C43/303

    摘要： The present invention describes a novel synthetic method for preparing the key intermediate 2,6,10-trimethyl-1,1-dialkoxy-3,5,9-undecatriene of lycopene. An existing synthetic method have some disadvantages that it is very difficult to gain the raw material dialkyl 4-methyl-5,5-diakoxy-1-pentene-1-phosphonate (10) because no effective synthetic method can be adopted, and furthermore the obtained target compound is composed of several cis/trans isomers. This invention relates to a process comprising a condensation step wherein a starting C10-phosphonate is changed to its carbanion completely at a temperature of −40˜30 under an atmosphere of a non-reactive gas in an organic solvent catalyzed by base, and then C4-dialkyl is added to undergo Wittig-Horner condensation. This invention affords all trans C14-acetal and this method is characterized with the advantages of simple procedure, easy access to raw material and low cost, which makes it has the value of industrial application.

    摘要翻译： 本发明描述了一种制备番茄红素关键中间体2,6,10-三甲基-1,1-二烷氧基-3,5,9-十一碳三烯的新型合成方法。 现有的合成方法有一些缺点，因为没有有效的合成方法，难以获得原料的4-甲基-5,5-二烷氧基-1-戊烯-1-膦酸二烷基酯（10），此外， 得到的目标化合物由几种顺式/反式异构体组成。 本发明涉及一种包括缩合步骤的方法，其中起始C10-膦酸酯在-40〜30℃的温度下在非反应性气体的气氛中在由碱催化的有机溶剂中完全变成其碳负离子，然后将C4 加入二烷基以进行Wittig-Horner冷凝。 本发明提供全反式C14-缩醛，该方法的特点是操作简单，易于获得原料，成本低廉，具有工业应用价值。

    SYNTHETIC SPILANTHOL AND USE THEREOF
    15.
    发明申请
    SYNTHETIC SPILANTHOL AND USE THEREOF 审中-公开
    合成螺旋体及其用途

    公开(公告)号：US20140227200A1

    公开(公告)日：2014-08-14

    申请号：US14257755

    申请日：2014-04-21

    申请人： Takasago International Corporation

    发明人： Louis Lombardo ,  Michael E. Lankin ,  Kenya Ishida ,  Shigeru Tanaka ,  Hideo Ujihara ,  Kenji Yagi ,  Jennifer B. Tartaglia ,  Carter B. Green ,  Amrit S. Mankoo

    IPC分类号： A61K8/42 ,  A23G1/32 ,  A23G4/06 ,  A23G3/36 ,  A61Q11/00 ,  A23L1/226

    CPC分类号： A61K8/42 ,  A23G1/32 ,  A23G3/36 ,  A23G4/06 ,  A23L27/202 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q15/00 ,  C07C43/303 ,  C07C45/41 ,  C07C57/66 ,  C07C231/12 ,  C07C233/09 ,  C07C235/28 ,  C07C309/66 ,  C12P13/02 ,  C07C47/21

    摘要： The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E,6E,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E,6Z,8Z)—N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided. Synthetic spilanthol flavor compositions can be added to orally consumed products, such as, but not limited to, foods, beverages, pharmaceuticals, nutraceuticals, or therapeutic compositions, oral personal care products, gums (e.g. chewing gum or bubble gum), candy or lozenges.

    摘要翻译： 本申请提供了包括（2E，6Z，8E）-N-（2-甲基丙基）-2,6,8-十一三烯酰胺的合成稀释剂风味组合物。 （2E，6E，8E）-N-（2-甲基丙基）-2,6,8-十一三烯酰胺和（2E，6Z，8Z）-N-（2- 甲基丙基）-2,6,8-十一三烯酰胺，（N-（2-甲基丙基）-2,6,8-癸三酰胺以有效赋予唾液或叮咬效果同时减少脱落感觉的量存在，相比之下 在消费口服易消化产品时，增加唾液分泌和/或提供刺痛感的方法包括向产品中加入合成的稀释剂风味组合物也是 合成的稀释剂风味组合物可以添加到口服食品中，例如但不限于食品，饮料，药物，营养保健品或治疗组合物，口腔个人护理产品，牙龈（例如口香糖或泡泡糖），糖果 或锭剂。

    Method for the production of polyoxymethylene dialkyl ethers from trioxan and dialkylethers
    18.
    发明授权
    Method for the production of polyoxymethylene dialkyl ethers from trioxan and dialkylethers 失效
    从三烷和二烷基醚生产聚亚甲基二烷基醚的方法

    公开(公告)号：US07999140B2

    公开(公告)日：2011-08-16

    申请号：US11917192

    申请日：2006-06-12

    申请人： Eckhard Stroefer ,  Heiner Schelling ,  Hans Hasse ,  Sergej Blagov

    发明人： Eckhard Stroefer ,  Heiner Schelling ,  Hans Hasse ,  Sergej Blagov

    IPC分类号： C07C41/18

    CPC分类号： C07C41/50 ,  C07C41/58 ,  C07C43/303 ,  C07C43/30

    摘要： A process for preparing polyoxymethylene dialkyl ethers of the formula H2m+1CmO(CH2O)nCmH2m+1 where n=2-10, m, identically or differently,=1 or 2, in which a dialkyl ether selected from dimethyl ether, methyl ethyl ether and diethyl ether, and trioxane are fed into a reactor and reacted in the presence of an acidic catalyst, the amount of water introduced into the reaction mixture by the dialkyl ether, trioxane and/or the catalyst being

    摘要翻译： 制备式H2m + 1CmO（CH2O）nCmH2m + 1的聚氧化亚甲基二烷基醚的方法，其中n = 2-10，m，相同或不同，= 1或2，其中选自二甲醚，甲基乙基醚 和二乙醚和三恶烷进料到反应器中并在酸性催化剂存在下反应，基于二烷基醚，三恶烷和/或催化剂引入到反应混合物中的水的量基于 反应混合物。