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    PROCESS FOR PRODUCING WINE LACTONE
    1.
    发明申请
    PROCESS FOR PRODUCING WINE LACTONE 审中-公开

    公开(公告)号：US20130245286A1

    公开(公告)日：2013-09-19

    申请号：US13887566

    申请日：2013-05-06

    申请人： TAKASAGO INTERNATIONAL CORPORATION

    发明人： Kenji Yagi ,  Yasuhiro Komatsuki ,  Hideo Ujihara ,  Kenya Ishida

    IPC分类号： C07D307/77

    CPC分类号： C07D307/83 ,  C07D307/77

    摘要： The present invention relates to a method comprising (A) reacting a β-keto ester with a 2-halo ester under basic conditions to obtain a 2-aceto-3-methyl-succinic acid ester; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, optionally followed by a decarboxylation reaction and hydrolysis, etc., to obtain an α-methyl-γ-keto acid; and (C) reducing the resulting α-methyl-γ-keto acid to obtain wine lactone or a stereoisomer thereof or a mixture thereof. Alternatively, the present invention relates to a method comprising step (A) as recited above; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, followed by decarboxylation reaction to obtain an α-methyl-γ-keto acid ester; and (E) reducing the resulting α-methyl-γ-keto acid ester in the presence of a ruthenium complex having a specific structure and in the presence of a hydrogen donor to obtain wine lactone or a stereoisomer thereof or a mixture thereof.

    METHOD FOR PRODUCING ETHER COMPOUND
    2.
    发明申请
    METHOD FOR PRODUCING ETHER COMPOUND 有权
    生产醚化合物的方法

    公开(公告)号：US20150011799A1

    公开(公告)日：2015-01-08

    申请号：US14376988

    申请日：2013-02-05

    申请人： TAKASAGO INTERNATIONAL CORPORATION

    发明人： Yasuhiro Komatsuki ,  Kenya Ishida ,  Kenji Yagi

    IPC分类号： C07C41/01 ,  C07C41/18

    CPC分类号： C07C41/01 ,  C07C41/18 ,  C07C2601/12 ,  C07C2602/42 ,  C07C43/23 ,  C07C43/115 ,  C07C43/164 ,  C07C43/1783

    摘要： An object of the present invention is to provide a method for producing an ether compound easily in a small number of steps at lower costs in high yields.The present invention relates to a method in which the ether compound represented by the general formula (1) is produced by reacting the specific carbonyl compound specified in the general formula (2) and the specific dialkoxy compound specified in the general formula (3) with hydrogen in the presence of a hydrogenation catalyst and an acidic substance to perform hydrogenation.

    摘要翻译： 本发明的目的在于提供以较低成本容易地以少量的步骤生产醚化合物的方法。 本发明涉及通式（1）表示的醚化合物的制造方法，其特征在于，将通式（2）中规定的特定羰基化合物与通式（3）中规定的特定二烷氧基化合物与通式 氢气在氢化催化剂和酸性物质的存在下进行氢化。

    METHOD FOR PRODUCING NITRILE
    5.
    发明申请
    METHOD FOR PRODUCING NITRILE 有权
    生产氮的方法

    公开(公告)号：US20150148558A1

    公开(公告)日：2015-05-28

    申请号：US14397224

    申请日：2013-05-20

    申请人： TAKASAGO INTERNATIONAL CORPORATION

    发明人： Kenji Yagi ,  Kenya Ishida

    IPC分类号： C07C253/00

    CPC分类号： C07C253/00 ,  B01J27/1806 ,  C07C239/10 ,  C07C255/07 ,  C07C255/33

    摘要： The present invention provides a method for producing a nitrile represented by general formula (1) (in the formula, R denotes an optionally substituted alkyl group, alkenyl group, dienyl group, aralkyl group or aryl group having a total of 3-20 carbon atoms), and the method includes heating an aldoxime represented by general formula (2) (in the formula, R denotes the same groups as those mentioned above) at 80-250° C. in the presence of an alkali metal or alkaline earth metal salt of phosphoric acid (catalyst A) and distilling off water generated as the reaction progresses to outside the reaction system.

    摘要翻译： 本发明提供一种制备由通式（1）表示的腈的方法（式中，R表示任意取代的烷基，烯基，二烯基，芳烷基或总碳原子数为3-20的芳基） ），该方法包括在碱金属或碱土金属盐的存在下，在80-250℃下加热通式（2）表示的醛肟（式中，R表示与上述相同的基团） 的磷酸（催化剂A），并且当反应进行到反应体系外时产生的蒸馏水。

    SYNTHETIC SPILANTHOL AND USE THEREOF
    6.
    发明申请
    SYNTHETIC SPILANTHOL AND USE THEREOF 审中-公开
    合成螺旋体及其用途

    公开(公告)号：US20140227200A1

    公开(公告)日：2014-08-14

    申请号：US14257755

    申请日：2014-04-21

    申请人： Takasago International Corporation

    发明人： Louis Lombardo ,  Michael E. Lankin ,  Kenya Ishida ,  Shigeru Tanaka ,  Hideo Ujihara ,  Kenji Yagi ,  Jennifer B. Tartaglia ,  Carter B. Green ,  Amrit S. Mankoo

    IPC分类号： A61K8/42 ,  A23G1/32 ,  A23G4/06 ,  A23G3/36 ,  A61Q11/00 ,  A23L1/226

    CPC分类号： A61K8/42 ,  A23G1/32 ,  A23G3/36 ,  A23G4/06 ,  A23L27/202 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q15/00 ,  C07C43/303 ,  C07C45/41 ,  C07C57/66 ,  C07C231/12 ,  C07C233/09 ,  C07C235/28 ,  C07C309/66 ,  C12P13/02 ,  C07C47/21

    摘要： The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E,6E,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E,6Z,8Z)—N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided. Synthetic spilanthol flavor compositions can be added to orally consumed products, such as, but not limited to, foods, beverages, pharmaceuticals, nutraceuticals, or therapeutic compositions, oral personal care products, gums (e.g. chewing gum or bubble gum), candy or lozenges.

    摘要翻译： 本申请提供了包括（2E，6Z，8E）-N-（2-甲基丙基）-2,6,8-十一三烯酰胺的合成稀释剂风味组合物。 （2E，6E，8E）-N-（2-甲基丙基）-2,6,8-十一三烯酰胺和（2E，6Z，8Z）-N-（2- 甲基丙基）-2,6,8-十一三烯酰胺，（N-（2-甲基丙基）-2,6,8-癸三酰胺以有效赋予唾液或叮咬效果同时减少脱落感觉的量存在，相比之下 在消费口服易消化产品时，增加唾液分泌和/或提供刺痛感的方法包括向产品中加入合成的稀释剂风味组合物也是 合成的稀释剂风味组合物可以添加到口服食品中，例如但不限于食品，饮料，药物，营养保健品或治疗组合物，口腔个人护理产品，牙龈（例如口香糖或泡泡糖），糖果 或锭剂。

    Method for producing nitrile
    7.
    发明授权
    Method for producing nitrile 有权
    腈的制备方法

    公开(公告)号：US09233916B2

    公开(公告)日：2016-01-12

    申请号：US14397224

    申请日：2013-05-20

    申请人： TAKASAGO INTERNATIONAL CORPORATION

    发明人： Kenji Yagi ,  Kenya Ishida

    IPC分类号： C07C253/00 ,  C07C253/20 ,  C07C255/07 ,  B01J27/18 ,  C07C239/10 ,  C07C255/33

    CPC分类号： C07C253/00 ,  B01J27/1806 ,  C07C239/10 ,  C07C255/07 ,  C07C255/33

    摘要： The present invention provides a method for producing a nitrile represented by general formula (1) (in the formula, R denotes an optionally substituted alkyl group, alkenyl group, dienyl group, aralkyl group or aryl group having a total of 3-20 carbon atoms), and the method includes heating an aldoxime represented by general formula (2) (in the formula, R denotes the same groups as those mentioned above) at 80-250° C. in the presence of an alkali metal or alkaline earth metal salt of phosphoric acid (catalyst A) and distilling off water generated as the reaction progresses to outside the reaction system.

    摘要翻译： 本发明提供一种制备由通式（1）表示的腈的方法（式中，R表示任意取代的烷基，烯基，二烯基，芳烷基或总碳原子数为3-20的芳基） ），该方法包括在碱金属或碱土金属盐的存在下，在80-250℃下加热通式（2）表示的醛肟（式中，R表示与上述相同的基团） 的磷酸（催化剂A），并且当反应进行到反应体系外时产生的蒸馏水。

    METHOD FOR PRODUCING HIGH-PURITY CERAMIDE
    8.
    发明申请
    METHOD FOR PRODUCING HIGH-PURITY CERAMIDE 有权
    生产高纯度CERAMIDE的方法

    公开(公告)号：US20140364649A1

    公开(公告)日：2014-12-11

    申请号：US14366883

    申请日：2012-11-07

    申请人： Takasago International Corporation

    发明人： Kenya Ishida ,  Kenji Yagi

    IPC分类号： C07C231/02 ,  C07C235/08 ,  C07C231/24

    CPC分类号： C07C231/02 ,  C07B2200/07 ,  C07C231/22 ,  C07C231/24 ,  C07C233/18 ,  C07C235/08

    摘要： Provided is a method for producing an optically active ceramide by an N-acylation (amidation) reaction of an optically active aminodiol, wherein a crude ceramide produced therein is purified by an industrially advantageous process. Namely, provided is a method for producing a high-purity ceramide that has high diastereo purity with high yield. A high-purity ceramide is produced by: a step wherein a ceramide represented by general formula (1) is produced by reacting an aminodiol with an alkyl ester having 1-5 carbon atoms of an aliphatic carboxylic acid having 12-24 carbon atoms, said aliphatic carboxylic acid optionally having a hydroxyl group, in a hydrocarbon solvent having 5-10 carbon atoms; and a step wherein an alcohol having 1-3 carbon atoms is added into the reaction mixture obtained in the preceding step, thereby causing crystals to precipitate. (In the formula, R1 represents an alkyl group which has 13-17 carbon atoms and optionally has a carbon-carbon unsaturated bond; R2 represents an alkyl group which has 11-23 carbon atoms and optionally has a hydroxyl group; and represents an optically active state.)

    摘要翻译： 提供了通过光学活性氨基二醇的N-酰化（酰胺化）反应制备光学活性神经酰胺的方法，其中通过工业上有利的方法纯化其中产生的粗制神经酰胺。 即，提供高纯度的高纯度神经酰胺的制造方法。 高纯度神经酰胺是通过以下步骤生产的：其中由通式（1）表示的神经酰胺通过氨基二醇与具有12-24个碳原子的脂族羧酸的具有1-5个碳原子的烷基酯反应来制备，所述 任选具有羟基的脂族羧酸，在具有5-10个碳原子的烃溶剂中; 并将其中将具有1-3个碳原子的醇加入到前述步骤中获得的反应混合物中，从而使晶体沉淀。 （式中，R 1表示碳原子数为13〜17的烷基，可以具有碳 - 碳不饱和键; R 2表示碳原子数为11〜23的烷基，可以具有羟基， 活跃状态）

    PROCESS FOR PRODUCING WINE LACTONE
    9.
    发明申请
    PROCESS FOR PRODUCING WINE LACTONE 审中-公开
    生产葡萄酒的方法

    公开(公告)号：US20130245287A1

    公开(公告)日：2013-09-19

    申请号：US13887564

    申请日：2013-05-06

    申请人： TAKASAGO INTERNATIONAL CORPORATION

    发明人： Kenji Yagi ,  Yasuhiro Komatsuki ,  Hideo Ujihara ,  Kenya Ishida

    IPC分类号： C07D307/83

    CPC分类号： C07D307/83 ,  C07D307/77

    摘要： The present invention relates to a method comprising (A) reacting a β-keto ester with a 2-halo ester under basic conditions to obtain a 2-aceto-3-methyl-succinic acid ester; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, optionally followed by a decarboxylation reaction and hydrolysis, etc., to obtain an α-methyl-γ-keto acid; and (C) reducing the resulting α-methyl-γ-keto acid to obtain wine lactone or a stereoisomer thereof or a mixture thereof. Alternatively, the present invention relates to a method comprising step (A) as recited above; (B) reacting the resulting 2-aceto-3-methyl-succinic acid ester with methyl vinyl ketone under basic conditions, followed by decarboxylation reaction to obtain an α-methyl-γ-keto acid ester; and (E) reducing the resulting α-methyl-γ-keto acid ester in the presence of a ruthenium complex having a specific structure and in the presence of a hydrogen donor to obtain wine lactone or a stereoisomer thereof or a mixture thereof.

    摘要翻译： 本发明涉及包含（A）在碱性条件下使β-酮酯与2-卤代酯反应得到2-乙酰-3-甲基 - 琥珀酸酯的方法; （B）在碱性条件下使所得2-乙酰-3-甲基 - 琥珀酸酯与甲基乙烯基酮反应，任选地进行脱羧反应和水解等，得到α-甲基-γ-酮酸; 和（C）将所得的α-甲基-γ-酮酸还原得到葡萄酒内酯或其立体异构体或其混合物。 或者，本发明涉及包含上述步骤（A）的方法; （B）在碱性条件下使所得的2-乙酰-3-甲基 - 琥珀酸酯与甲基乙烯基酮反应，然后进行脱羧反应，得到α-甲基-γ-酮酸酯; 和（E）在具有特定结构的钌络合物和氢供体存在下还原所得的α-甲基-γ-酮酸酯以获得葡萄糖内酯或其立体异构体或其混合物。