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    FAIL-SAFE RADIATION CONCEALMENT MECHANISMS FOR IMAGING CAPSULES
    12.
    发明申请
    FAIL-SAFE RADIATION CONCEALMENT MECHANISMS FOR IMAGING CAPSULES 有权
    用于成像胶囊的失效安全辐射保护机制

    公开(公告)号：US20140037069A1

    公开(公告)日：2014-02-06

    申请号：US13895345

    申请日：2013-05-15

    申请人： Check-Cap Ltd.

    发明人： Yoav KIMCHY ,  Rafi Sommer

    IPC分类号： A61B6/00

    CPC分类号： A61B6/4057 ,  A61B6/425 ,  A61B6/4258

    摘要： An imaging capsule with a fail-safe radiation mechanism includes a first rotatable disk with a radiation source mounted thereon and having a collimator structure allowing emission of radiation from radiation source from a few locations on the first disk. A second rotatable disk surrounds the first disk, is rotatable relative to first disk, and includes areas that block radiation and areas that are transparent to emission of radiation. In a rest position, second disk is situated relative to first disk such that areas that block radiation are blocking the emission of radiation from the locations on the circumference of the disk that allow the emission of radiation. A motor is activated to rotate one of the disks and allow emission of radiation. A connector is configured to automatically return first disk and second disk to the rest position when the motor is deactivated.

    摘要翻译： 具有故障安全辐射机构的成像胶囊包括其上安装有辐射源的第一可旋转盘，并具有允许从第一盘上的几个位置发射来自辐射源的辐射的准直器结构。 围绕第一盘的第二可旋转盘可相对于第一盘旋转，并且包括阻挡辐射的区域和对辐射发射透明的区域。 在静止位置，第二盘相对于第一盘定位，使得阻挡辐射的区域阻挡从盘周围的允许发射辐射的位置的辐射。 电机被激活以旋转盘中的一个并允许发射辐射。 连接器被配置为当电动机停用时自动地将第一盘和第二盘回到静止位置。

    METHOD AND APPARATUS FOR DUAL-MODALITY ULTRASONIC AND NUCLEAR EMISSION MAMMOGRAPHY
    13.
    发明申请
    METHOD AND APPARATUS FOR DUAL-MODALITY ULTRASONIC AND NUCLEAR EMISSION MAMMOGRAPHY 有权
    双模式超声和核发射摄像的方法和装置

    公开(公告)号：US20130101083A1

    公开(公告)日：2013-04-25

    申请号：US13701754

    申请日：2011-06-01

    申请人： Michael K. O'Connor

    发明人： Michael K. O'Connor

    IPC分类号： A61B6/00

    CPC分类号： A61B6/502 ,  A61B6/037 ,  A61B6/0414 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4291 ,  A61B6/4417 ,  A61B6/5247 ,  A61B8/0825 ,  A61B8/4416 ,  A61B8/485 ,  A61B90/11 ,  G21K1/025

    摘要： A molecular breast imaging (“MBI”} configured for combined MBI and ultrasound imaging or MBI-guided biopsy is provided. In one configuration, the MBI portion of the system includes two opposed gamma ray detectors, while in another configuration only one gamma ray detector is provided. In two detector configurations, a compression plate is provided to make contact with and apply light compression to the subject under examination. One of the gamma ray detectors is configured to be moveable with respect to the other detector such that the gamma ray detector can be moved away from the examination region, thereby allowing access to the breast for an ultrasound imaging system or a breast biopsy device.

    摘要翻译： 提供了一种配置用于组合MBI和超声成像或MBI指导活检的分子乳腺成像（“MBI”）。在一种配置中，系统的MBI部分包括两个相对的γ射线检测器，而在另一个配置中，仅一个伽马射线检测器 在两个检测器配置中，提供压缩板以与被检查物体接触并施加光压缩，其中一个伽马射线检测器被配置为可相对于另一检测器移动，使得伽马射线检测器 可以远离检查区域移动，从而允许进入用于超声成像系统或乳房活检装置的乳房。

    Intracorporeal-imaging head
    19.
    发明申请
    Intracorporeal-imaging head 审中-公开
    体内成像头

    公开(公告)号：US20040204646A1

    公开(公告)日：2004-10-14

    申请号：US10836223

    申请日：2004-05-03

    申请人： V-Target Technologies Ltd.

    发明人： Michael Nagler ,  Yoel Zilberstein

    IPC分类号： A61B005/05 ,  A61B006/00

    CPC分类号： G01T1/161 ,  A61B1/05 ,  A61B1/31 ,  A61B5/0035 ,  A61B5/06 ,  A61B5/415 ,  A61B5/418 ,  A61B6/4057 ,  A61B6/425 ,  A61B6/4258

    摘要： An intracorporeal-imaging head, is provided, which combines at least optical and radioactive-emission imaging, possibly also with high-resolution position tracking. The radioactive-emission-imaging probe has a wide-aperture, or coarse collimator, for high count-rate efficiency; nevertheless, the high-resolution position tracking ensures high resolution of the radioactive-emission image. Specifically, wide-aperture collimation-deconvolution algorithms are provided, for obtaining a high-efficiency, high resolution image of a radioactive-emission source, by scanning the radioactive-emission source with a probe of a wide-aperture collimator, and at the same time, monitoring the position of the radioactive-emission probe, at very fine time intervals, to obtain the equivalence of fine-aperture collimation. The blurring effect of the wide aperture is then corrected mathematically. The intracorporeal-imaging head may further include ultrasound and MRI imagers, as well as a surgical instrument, such as a biopsy needle, a knife, a cryosurgery device, a resection wire, a laser ablation device, an ultrasound ablation device, other devices for localized radiation ablations, devices for implanting brachytherapy seeds, and other minimally invasive devices. According to another embodiment, an intracorporeal-detecting head is provided, which combines at least optical and radioactive-emission detectors, for a nullYes or Nonull type detection, by the at least two modalities.

    摘要翻译： 提供体内成像头，其至少结合光学和放射性发射成像，可能还具有高分辨率位置跟踪。 放射性发射成像探针具有宽孔径或粗略的准直器，以实现高计数率效率; 然而，高分辨率位置跟踪确保了放射性发射图像的高分辨率。 具体地说，提供宽孔径准直 - 去卷积算法，用于通过用宽孔径准直器的探头扫描放射性发射源，并且在相同的情况下获得放射性发射源的高效率高分辨率图像 时间，以非常精细的时间间隔监测放射性发射探头的位置，以获得细孔准直的等效性。 然后在数学上校正宽光圈的模糊效果。 体内成像头可以进一步包括超声和MRI成像仪，以及手术器械，例如活检针，刀，冷冻手术装置，切除线，激光消融装置，超声消融装置，用于 局部放射线消融，用于植入近距离放射治疗种子的装置和其它微创装置。 根据另一个实施例，提供一种体内检测头，其通过至少两种方式将至少光学和放射性发射检测器组合为“是或否”型检测。

    Animal model for detection of vulnerable plaques
    20.
    发明授权
    Animal model for detection of vulnerable plaques 失效
    用于检测脆弱斑块的动物模型

    公开(公告)号：US06580016B2

    公开(公告)日：2003-06-17

    申请号：US09760182

    申请日：2001-01-12

    申请人： Paul S. Teirstein ,  Kenneth W. Carpenter ,  Istvan Szinai ,  David A. Schwartz

    发明人： Paul S. Teirstein ,  Kenneth W. Carpenter ,  Istvan Szinai ,  David A. Schwartz

    IPC分类号： A01K6700

    CPC分类号： A61K49/126 ,  A61B6/4057 ,  A61B6/481 ,  A61B6/508 ,  A61K49/0442 ,  A61K49/085 ,  A61K51/065 ,  G01N33/92 ,  G01N2400/40 ,  G01N2800/323

    摘要： The present invention provides in vivo methods for detection of vulnerable plaque in a subject in need thereof. In the invention method the subject is administered a diagnostic amount of a biologically compatible detectable lipid-avid agent, the detectable lipid-avid agent is allowed to penetrate arterial walls and attach to any lipid accumulations of oxidized LDL-cholesterol in arterial walls in the wall of an artery; unbound detectable lipid-avid agent is allowed to clear from the body by natural processes, and the presence of the detectable lipid-avid agent attached to the lipid accumulation in the wall of the artery is detected. Detection of bound lipid-avid agent indicates the presence of a vulnerable plaque and predicts a heightened risk of lethal heart attack or thrombus. The detectable lipid-avid agent is selected for its ability to penetrate arterial walls and bind with oxidized LDL-cholesterol in the lipid accumulation in a vulnerable plaque. Alternatively, macrophage-avid agents, for example a lipid-avid agent attached to a macrophage-specific antibody, can be used in the invention methods. The invention further includes methods for in vitro assays for detecting vulnerable plaque and a porcine animal model of vulnerable plaque useful for testing treatment modalities.

    摘要翻译： 本发明提供了在有需要的受试者中检测易损斑块的体内方法。 在本发明方法中，给予受试者诊断量的生物相容性可检测的脂质 - 抗体试剂，允许可检测的脂质激动剂渗透动脉壁并附着于壁中动脉壁中氧化的LDL-胆固醇的任何脂质积聚 的动脉 通过天然过程使未结合的可检测的脂质 - 抗体试剂从身体中清除，并且检测附着在动脉壁中的脂质积聚的可检测的脂质激动剂的存在。 检测结合的脂质抗体剂表明存在易受伤害的斑块，并预测致死性心脏病发作或血栓的风险增加。 选择可检测的脂质抗体试剂，以其穿透动脉壁并与氧化的LDL-胆固醇结合在易损斑块中的脂质积聚中。 或者，巨噬细胞激动剂，例如与巨噬细胞特异性抗体连接的脂质 - 抗体试剂可用于本发明的方法中。 本发明还包括用于检测易损斑块的体外测定方法和用于测试治疗方式的易损斑块的猪动物模型。