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公开(公告)号：US20150274672A1
公开(公告)日：2015-10-01
申请号：US14434524
申请日：2013-10-11
申请人： Mariappan CHELLIAH , Hong Dong CHU , Jason M. COX , John S. DEBENHAM , Keith EAGEN , Ping LAN , Clare LONDON , Michael A. PLOTKIN , Unmesh SHAH , Christopher Joseph SINZ , Zhongxiang SUN , Henry M. VACCARO , Skikanth KATRAMAN , MERCK SHARP & DOHME CORP.
发明人： Mariappan Chelliah , Hong Dong Chu , Jason M. Cox , John S. Debenham , Keith Eagen , Ping Lan , Clare London , Michael A. Plotkin , Unmesh Shah , Christopher Joseph Sinz , Zhongxiang Sun , Henry M. Vaccaro , Srikanth Venkatraman
IPC分类号： C07D221/20 , C07D401/04 , C07D491/107 , C07D405/10
CPC分类号： C07D221/20 , C07D401/04 , C07D401/12 , C07D405/10 , C07D491/107
摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 本发明涉及由式（I）表示的化合物及其药学上可接受的盐，其可用于治疗或预防糖尿病，高脂血症，肥胖，炎症相关疾病及相关疾病和病症。 该化合物可用作G蛋白偶联受体GPR120的激动剂。 还包括药物组合物和治疗方法。
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公开(公告)号：US09567333B2
公开(公告)日：2017-02-14
申请号：US14886563
申请日：2015-10-19
发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Paul Ratcliffe , Jerry Andrew Taylor , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： This invention relates to triazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译： 本发明涉及结构式的三唑并吡啶基化合物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。
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公开(公告)号：US20160333021A1
公开(公告)日：2016-11-17
申请号：US15110431
申请日：2015-01-16
发明人： Mihir Mandal , Haifeng Tang , Li Xiao , Jing Su , Guoqing Li , Shu-Wei Yang , Weidong Pan , Haiqun Tang , Reynalda DeJesus , Jacqueline Hicks , Matthew Lombardo , Hong Chu , William Hagmann , Alex Pasternak , Xin Gu , Jinlong Jiang , Shuzhi Dong , Fa-Xiang Ding , Clare London , Dipshikha Biswas , Katherine Young , David N. Hunter , Zhiqiang Zhao , Dexi Yang
IPC分类号： C07D491/048 , A61K31/41 , A61K45/06 , A61K31/407 , A61K31/197 , C07D405/12 , A61K31/5377 , C07D403/10 , A61K31/4192 , A61K31/496 , C07D401/10 , A61K31/454 , A61K31/4439 , C07D409/10 , C07D417/10 , A61K31/427 , C07D405/14 , C07D413/10 , A61K31/422 , A61K31/506 , A61K31/497 , A61K31/4178 , A61K31/501 , A61K31/4155 , C07D471/04 , A61K31/437 , C07D417/14 , C07D401/14 , C07D487/04 , A61K31/5025 , A61K31/4245 , A61K31/541 , C07D401/04 , C07D413/14 , A61K31/55 , C07D471/10 , C07D257/04
CPC分类号： C07D491/048 , A61K31/197 , A61K31/407 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D257/04 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , Y02A50/473 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
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公开(公告)号：US20160039817A1
公开(公告)日：2016-02-11
申请号：US14886563
申请日：2015-10-19
发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Paul Ratcliffe , Jerry Andrew Taylor , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： This invention relates to triazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译： 本发明涉及结构式的三唑并吡啶基化合物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。
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公开(公告)号：US20140288094A1
公开(公告)日：2014-09-25
申请号：US14346518
申请日：2012-09-17
发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D487/04 , A61K31/437 , A61K31/519 , C07D471/04
CPC分类号： A61K31/519 , A61K31/437 , A61K31/444 , C07D471/04 , C07D487/04
摘要： This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
摘要翻译： 本发明涉及以下结构式的吡唑并吡啶基化合物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及潜在的治疗，改善或预防可通过抑制醛固酮合酶治疗的病症的方法。
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16.发明申请TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权四环杂环化合物及其用于治疗病毒性疾病的方法公开(公告)号：US20140213571A1
公开(公告)日：2014-07-31
申请号：US14343450
申请日：2012-08-20
发明人： Nigel J. Liverton , Casey Cameron McComas , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Shuwen He , Xing Dai , Hong Liu , Zhong Lai , Clare London , Dong Xiao , Nicolas Zorn , Ravi Nargund
IPC分类号： A61K31/553 , A61K31/519 , A61K31/437 , A61K31/407 , C07D498/22 , C07D498/14 , C07D491/147 , C07D491/052 , A61K45/06 , A61K31/5365 , C07D498/04
CPC分类号： A61K31/553 , A61K31/407 , A61K31/437 , A61K31/519 , A61K31/5365 , A61K45/06 , C07D491/052 , C07D491/147 , C07D498/04 , C07D498/14 , C07D498/22 , Y02A50/387 , Y02A50/389 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物 并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。
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公开(公告)号：US09844553B2
公开(公告)日：2017-12-19
申请号：US15139361
申请日：2016-04-27
发明人： D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
IPC分类号： C07D487/04 , A61K31/519 , C07D471/04 , A61K31/437 , A61K31/444
CPC分类号： A61K31/519 , A61K31/437 , A61K31/444 , C07D471/04 , C07D487/04
摘要： This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
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18.发明申请公开(公告)号：US20170273966A1
公开(公告)日：2017-09-28
申请号：US15508557
申请日：2015-08-31
发明人： Jason Imbriglio , Clare London , Zhijian Lu , James Tata , Yusheng Xiong , Ming You , Hyewon Youm
IPC分类号： A61K31/47 , C07C13/04 , A61K31/16 , C07D217/06
CPC分类号： A61K31/47 , A61K31/16 , C07C13/04 , C07D217/06 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention relates to a compound represented by formula I:and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardio renal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
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公开(公告)号：US09708270B2
公开(公告)日：2017-07-18
申请号：US14434524
申请日：2013-10-11
发明人： Mariappan Chelliah , Hong Dong Chu , Jason M. Cox , John S. Debenham , Keith Eagen , Ping Lan , Clare London , Michael A. Plotkin , Unmesh Shah , Christopher Joseph Sinz , Zhongxiang Sun , Henry M. Vaccaro , Srikanth Venkatraman
IPC分类号： C07D401/12 , C07D491/107 , C07D221/20 , C07D201/04 , C07D401/04 , C07D405/10
CPC分类号： C07D221/20 , C07D401/04 , C07D401/12 , C07D405/10 , C07D491/107
摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.
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公开(公告)号：US09522141B2
公开(公告)日：2016-12-20
申请号：US14651491
申请日：2013-12-17
IPC分类号： A61K31/4439 , A61K31/4725 , A61K31/497 , C07D401/04 , C07D403/14 , C07D403/04
CPC分类号： A61K31/4439 , A61K31/4725 , A61K31/497 , C07D401/04 , C07D403/04 , C07D403/14
摘要： This invention relates to indazole compounds of the structural formula: (structure represented) or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment or amelioration of conditions that could be treated by inhibiting aldosterone synthase.
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