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公开(公告)号：US09328138B2
公开(公告)日：2016-05-03
申请号：US14358050
申请日：2012-11-09
发明人： Michael T. Rudd , John McCauley , Nigel Liverton , Christiane Grisé-Bard , Marie-Christine Brochu , Sylvie Charron , Virender Aulakh , Benoit Bachand , Patrick Beaulieu , Helmi Zaghdane , Yongxin Han , Marco Ferrara , Steven Harper , Vincenzo Summa , Samuel Chackalamannil , Srikanth Venkatraman , Unmesh Shah , Francisco Velazquez
IPC分类号： A61K38/06 , C07K5/08 , C07K5/078 , C07K5/083 , C07K5/087 , A61K38/21 , C07K5/097 , A61K31/4745 , A61K31/5377 , A61K31/675 , A61K31/7056 , A61K38/00 , A61K38/12
CPC分类号： C07K5/08 , A61K31/4745 , A61K31/5377 , A61K31/675 , A61K31/7056 , A61K38/005 , A61K38/06 , A61K38/12 , A61K38/21 , C07K5/0804 , C07K5/0808 , C07K5/0812 , C07K5/0821 , A61K2300/00
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
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公开(公告)号：US20150274672A1
公开(公告)日：2015-10-01
申请号：US14434524
申请日：2013-10-11
申请人： Mariappan CHELLIAH , Hong Dong CHU , Jason M. COX , John S. DEBENHAM , Keith EAGEN , Ping LAN , Clare LONDON , Michael A. PLOTKIN , Unmesh SHAH , Christopher Joseph SINZ , Zhongxiang SUN , Henry M. VACCARO , Skikanth KATRAMAN , MERCK SHARP & DOHME CORP.
发明人： Mariappan Chelliah , Hong Dong Chu , Jason M. Cox , John S. Debenham , Keith Eagen , Ping Lan , Clare London , Michael A. Plotkin , Unmesh Shah , Christopher Joseph Sinz , Zhongxiang Sun , Henry M. Vaccaro , Srikanth Venkatraman
IPC分类号： C07D221/20 , C07D401/04 , C07D491/107 , C07D405/10
CPC分类号： C07D221/20 , C07D401/04 , C07D401/12 , C07D405/10 , C07D491/107
摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译： 本发明涉及由式（I）表示的化合物及其药学上可接受的盐，其可用于治疗或预防糖尿病，高脂血症，肥胖，炎症相关疾病及相关疾病和病症。 该化合物可用作G蛋白偶联受体GPR120的激动剂。 还包括药物组合物和治疗方法。
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公开(公告)号：US20190161448A1
公开(公告)日：2019-05-30
申请号：US16096710
申请日：2017-05-19
发明人： Gregory L. Adams , Jason M. Cox , John S. Debenham , Scott Edmondson , Eric J. Gilbert , Yan Guo , Yu Jiang , Hubert Josien , Hyunjin M. Kim , Ping Lan , Shouwu Miao , Christopher W. Plummer , Murali Rajagopalan , Unmesh Shah , Zhongxiang Sun , Quang T. Truong , Feroze Ujjainwalla , Francisco Velazquez , Srikanth Venkatraman , Takao Suzuki , Nengxue Wang
IPC分类号： C07D217/04 , C07D401/12 , C07D401/04 , C07D401/06 , C07D417/04 , C07D417/14 , C07D417/12 , C07D413/04 , A61P3/10 , A61P3/06 , A61P3/04 , A61P29/00
摘要： The present invention relates to a compound represented by formula (I) and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.
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公开(公告)号：US20200347020A1
公开(公告)日：2020-11-05
申请号：US16935565
申请日：2020-07-22
发明人： Gregory L. Adams , Jason M. Cox , John S. Debenham , Scott Edmondson , Eric J. Gilbert , Yan Guo , Yu Jiang , Hubert Josien , Hyunjin M. Kim , Ping Lan , Shouwu Miao , Christopher W. Plummer , Murali Rajagopalan , Unmesh Shah , Zhongxiang Sun , Quang T. Truong , Feroze Ujjainwalla , Francisco Velazquez , Srikanth Venkatraman , Takao Suzuki , Nengxue Wang
IPC分类号： C07D217/04 , C07D401/04 , C07D401/12 , C07D413/04 , C07D417/12 , C07D417/14 , C07D401/06 , C07D417/04 , A61K31/4725 , C07D417/06 , C07D217/22 , A61K45/06 , A61K31/472 , A61K9/48 , A61P3/04 , A61P3/06 , A61P3/10 , A61P29/00
摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.
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公开(公告)号：US20140296136A1
公开(公告)日：2014-10-02
申请号：US14358050
申请日：2012-11-09
申请人： MERCK SHARP & DOHME CORP. , MERCK CANADA INC. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L.
发明人： Michael T. Rudd , John McCauley , Nigel Liverton , Christiane Grisé-Bard , Marie-Christine Brochu , Sylvie Charron , Virender Aulakh , Benoit Bachand , Patrick Beaulieu , Helmi Zaghdane , Yongxin Han , Marco Ferrara , Steven Harper , Vincenzo Summa , Samuel Chackalamannil , Srikanth Venkatraman , Unmesh Shah , Francisco Velazquez
IPC分类号： C07K5/08 , A61K31/4745 , A61K31/7056 , A61K31/5377 , A61K38/06 , A61K38/00 , A61K31/675
CPC分类号： C07K5/08 , A61K31/4745 , A61K31/5377 , A61K31/675 , A61K31/7056 , A61K38/005 , A61K38/06 , A61K38/12 , A61K38/21 , C07K5/0804 , C07K5/0808 , C07K5/0812 , C07K5/0821 , A61K2300/00
摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式（I）的大环化合物。
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公开(公告)号：US11161819B2
公开(公告)日：2021-11-02
申请号：US16935565
申请日：2020-07-22
发明人： Gregory L. Adams , Jason M. Cox , John S. Debenham , Scott Edmondson , Eric J. Gilbert , Yan Guo , Yu Jiang , Hubert Josien , Hyunjin M. Kim , Ping Lan , Shouwu Miao , Christopher W. Plummer , Murali Rajagopalan , Unmesh Shah , Zhongxiang Sun , Quang T. Truong , Feroze Ujjainwalla , Francisco Velazquez , Srikanth Venkatraman , Takao Suzuki , Nengxue Wang
IPC分类号： C07D217/04 , C07D401/04 , C07D401/12 , C07D413/04 , C07D417/12 , C07D417/14 , C07D401/06 , C07D417/04 , A61K31/4725 , C07D417/06 , C07D217/22 , A61K45/06 , A61K31/472 , A61K9/48 , A61P3/04 , A61P3/06 , A61P3/10 , A61P29/00
摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.
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公开(公告)号：US09708270B2
公开(公告)日：2017-07-18
申请号：US14434524
申请日：2013-10-11
发明人： Mariappan Chelliah , Hong Dong Chu , Jason M. Cox , John S. Debenham , Keith Eagen , Ping Lan , Clare London , Michael A. Plotkin , Unmesh Shah , Christopher Joseph Sinz , Zhongxiang Sun , Henry M. Vaccaro , Srikanth Venkatraman
IPC分类号： C07D401/12 , C07D491/107 , C07D221/20 , C07D201/04 , C07D401/04 , C07D405/10
CPC分类号： C07D221/20 , C07D401/04 , C07D401/12 , C07D405/10 , C07D491/107
摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.
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公开(公告)号：US08987195B2
公开(公告)日：2015-03-24
申请号：US13960343
申请日：2013-08-06
发明人： Thomas Bara , Sathesh Bhat , Dipshikha Biswas , Linda Brockunier , Duane A. Burnett , Samuel Chackalamannil , Mariappan V. Chelliah , Austin Chen , Martin Clasby , Vince J. Colandrea , Zhuyan Guo , Yongxin Han , Charles Jayne , Hubert Josien , Karen Marcantonio , Shouwu Miao , Santhosh Neelamkavil , Patrick Pinto , Murali Rajagopalan , Unmesh Shah , Francisco Velazquez , Srikanth Venkatraman , Yan Xia
IPC分类号： A61K38/00 , C07K5/08 , A61K38/06 , A61K45/06 , C07D491/22 , C07D419/00
CPC分类号： C07K5/08 , A61K38/06 , A61K45/06 , C07D419/00 , C07D491/22
摘要： The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.
摘要翻译： 本发明涉及含有螺环状的丙型肝炎病毒（HCV）NS3蛋白酶抑制剂，这些化合物的用途，以及这些化合物的合成。
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