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公开(公告)号：US10081640B2
公开(公告)日：2018-09-25
申请号：US15216548
申请日：2016-07-21
Applicant: ImmunoGen, Inc.
Inventor： Baudouin Gérard , Manami Shizuka , Michael Louis Miller , Richard A. Silva
IPC: C07K17/00 , A61K38/06 , C07K5/00 , C07K7/00 , C07K16/00 , C07D519/00 , C07D487/04 , C07K5/083
CPC classification number: C07D519/00 , C07D487/04 , C07K5/0804
Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
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公开(公告)号：US10071074B2
公开(公告)日：2018-09-11
申请号：US15359703
申请日：2016-11-23
Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
Inventor： Italo Beria , Michele Caruso , Vittoria Lupi , Paolo Orsini , Matteo Salsa , Achille Panzeri
IPC: A61K31/407 , A61K31/496 , A61K38/05 , A61K38/06 , A61K45/06 , C07D495/04 , C07K5/062 , C07K5/083 , A61K47/54
CPC classification number: A61K31/407 , A61K31/496 , A61K38/05 , A61K38/06 , A61K45/06 , A61K47/545 , C07D495/04 , C07K5/06017 , C07K5/0804
Abstract: The present invention relates to a novel class of alkylating agents comprising a thieno-indole moiety linked to a DNA-binding moiety, which have cytotoxic activity and are useful in treating diseases such as cancer, cellular proliferation disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising them and methods of treating diseases utilizing such compounds or the pharmaceutical composition containing them. The invention also relates to the use of this novel class of alkylating agents in the preparation of conjugates. The present invention also relates to methods of treating ovarian cancer by administration of compounds of formula (II):
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公开(公告)号：US20180057528A1
公开(公告)日：2018-03-01
申请号：US15470596
申请日：2017-03-27
Applicant: viDA Therapeutics Inc.
Inventor： Dale R. Cameron
CPC classification number: C07K5/0821 , A61K38/00 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0827
Abstract: Granzyme B inhibitor compounds, compositions that include the compounds, and methods for using the compounds. The compounds of the invention have advantageous water solubility and effectively inhibit Granzyme B.
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公开(公告)号：US09605021B2
公开(公告)日：2017-03-28
申请号：US14869750
申请日：2015-09-29
Applicant: viDA Therapeutics Inc.
Inventor： Dale R. Cameron
CPC classification number: C07K5/0821 , A61K38/00 , C07K5/0804 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0827
Abstract: Granzyme B inhibitor compounds, compositions that include the compounds, and methods for using the compounds. The compounds of the invention have advantageous water solubility and effectively inhibit Granzyme B.
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公开(公告)号：US09328138B2
公开(公告)日：2016-05-03
申请号：US14358050
申请日：2012-11-09
Applicant: Merck Sharp & Dohme Corp. , MSD Italia S.R.L. , Merck Canada Inc.
Inventor： Michael T. Rudd , John McCauley , Nigel Liverton , Christiane Grisé-Bard , Marie-Christine Brochu , Sylvie Charron , Virender Aulakh , Benoit Bachand , Patrick Beaulieu , Helmi Zaghdane , Yongxin Han , Marco Ferrara , Steven Harper , Vincenzo Summa , Samuel Chackalamannil , Srikanth Venkatraman , Unmesh Shah , Francisco Velazquez
IPC: A61K38/06 , C07K5/08 , C07K5/078 , C07K5/083 , C07K5/087 , A61K38/21 , C07K5/097 , A61K31/4745 , A61K31/5377 , A61K31/675 , A61K31/7056 , A61K38/00 , A61K38/12
CPC classification number: C07K5/08 , A61K31/4745 , A61K31/5377 , A61K31/675 , A61K31/7056 , A61K38/005 , A61K38/06 , A61K38/12 , A61K38/21 , C07K5/0804 , C07K5/0808 , C07K5/0812 , C07K5/0821 , A61K2300/00
Abstract: The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
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Patent Agency Ranking
6.发明授权公开(公告)号：US09321808B2
公开(公告)日：2016-04-26
申请号：US14379675
申请日：2012-02-20
Applicant: Pierfausto Seneci , Laura Belvisi , Federica Cossu , Domenico Delia , Carmelo Drago , Daniele Lecis , Stefano Maiorana , Leonardo Pierpaolo Manzoni , Eloise Mastrangelo , Mario Milani de Mayo de Mari , Paola Maria Chiara Perego , Francesca Vasile
Inventor： Pierfausto Seneci , Laura Belvisi , Federica Cossu , Domenico Delia , Carmelo Drago , Daniele Lecis , Stefano Maiorana , Leonardo Pierpaolo Manzoni , Eloise Mastrangelo , Mario Milani de Mayo de Mari , Paola Maria Chiara Perego , Francesca Vasile
IPC: C07D487/04 , C07K5/103 , C07K5/083 , C07D519/00 , A61K38/06 , A61K38/07 , A61K45/06 , A61K38/00
CPC classification number: A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D519/00 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/1005 , C07K5/1008 , C07K5/101
Abstract: The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
Abstract translation: 本发明涉及具有作为细胞凋亡蛋白抑制剂（IAP）抑制剂的功能的Smac的构象约束的同型和异二聚体模拟物，本发明还涉及这些化合物在治疗中的用途，其中凋亡细胞死亡的诱导是有益的， 特别是在癌症的治疗中，单独或与其它活性成分组合。
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公开(公告)号：US20150209403A1
公开(公告)日：2015-07-30
申请号：US14606369
申请日：2015-01-27
Applicant: AbbVie Inc.
Inventor： Walid M. Awni , Prajakta Badri , Daniel E. Cohen , Sandeep Dutta , Amit Khatri , Rajeev M. Menon , Thomas Podsadecki , Akshanth Polepally , Roger Trinh , Tianli Wang , Jiuhong Zha
IPC: A61K38/06 , A61K38/05 , A61K45/06 , A61K31/513
CPC classification number: A61K38/06 , A61K31/4025 , A61K31/427 , A61K31/496 , A61K31/497 , A61K31/513 , A61K31/55 , A61K38/05 , A61K45/06 , C07K5/0804 , A61K2300/00
Abstract: This application features dose adjustment for drugs co-administered with Compound 1, Compound 2 and/or Compound 3.
Abstract translation: 本申请对与化合物1，化合物2和/或化合物3共同施用的药物具有剂量调整。
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公开(公告)号：US20150175657A1
公开(公告)日：2015-06-25
申请号：US14639228
申请日：2015-03-05
Applicant: Celgene Avilomics Research, Inc.
Inventor： Deqiang Niu , Russell C. Petter , Lixin Qiao , Juswinder Signh
CPC classification number: C07K7/06 , A61K31/40 , A61K31/403 , A61K31/4439 , A61K31/4965 , A61K31/506 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K45/06 , C07D209/52 , C07D401/12 , C07D403/12 , C07K5/06165 , C07K5/0802 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/0821 , C07K5/0827 , C07K5/1016 , C12N9/506 , C12N9/99 , C12Y304/21098
Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
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9.发明申请New Homo- and Heterodimeric SMAC Mimetic Compounds as Apoptosis Inducers 有权新型均质和异二聚体SMAC模拟化合物作为细胞凋亡诱导剂公开(公告)号：US20150119342A1
公开(公告)日：2015-04-30
申请号：US14379675
申请日：2012-02-20
Applicant: Pierfausto Seneci , Laura Belvisi , Federica Cossu , Domenico Delia , Carmelo Drago , Daniele Lecis , Stefano Maiorana , Leonardo Pierpaolo Manzoni , Eloise Mastrangelo , Mario Milani de Mayo de Mari , Paola Maria Chiara Perego , Francesca Vasile
Inventor： Pierfausto Seneci , Laura Belvisi , Federica Cossu , Domenico Delia , Carmelo Drago , Daniele Lecis , Stefano Maiorana , Leonardo Pierpaolo Manzoni , Eloise Mastrangelo , Mario Milani de Mayo de Mari , Paola Maria Chiara Perego , Francesca Vasile
CPC classification number: A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D519/00 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/1005 , C07K5/1008 , C07K5/101
Abstract: The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
Abstract translation: 本发明涉及具有作为细胞凋亡蛋白抑制剂（IAP）抑制剂的功能的Smac的构象约束的同型和异二聚体模拟物，本发明还涉及这些化合物在治疗中的用途，其中凋亡细胞死亡的诱导是有益的， 特别是在癌症的治疗中，单独或与其它活性成分组合。
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公开(公告)号：US20140051626A1
公开(公告)日：2014-02-20
申请号：US13932945
申请日：2013-07-01
Applicant: Jeromy J. Cottell , John O. Link , Scott D. Schroeder , James Taylor , Winston C. Tse , Randall W. Vivian , Zheng-Yu Yang
Inventor： Jeromy J. Cottell , John O. Link , Scott D. Schroeder , James Taylor , Winston C. Tse , Randall W. Vivian , Zheng-Yu Yang
IPC: C07K5/083
CPC classification number: C07K5/0808 , A61K38/00 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04 , C07K5/0804 , C07K5/0812 , C07K5/0821
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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