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![SUBSTITUTED BENZO[5,6][1,4]DIAZEPINO[1,2-a]INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS](/abs-image/US/2024/06/20/US20240197898A1/abs.jpg.150x150.jpg)
1.发明公开公开(公告)号：US20240197898A1
公开(公告)日：2024-06-20
申请号：US18229476
申请日：2023-08-02
申请人： IMMUNOGEN, INC.
CPC分类号： A61K47/6803 , A61K47/6869 , A61P35/00
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formulae (I), (II) and (III). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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公开(公告)号：US20240190956A1
公开(公告)日：2024-06-13
申请号：US18343455
申请日：2023-06-28
申请人： IMMUNOGEN, INC.
发明人： Nathan Elliott Fishkin , Daniel J. Tavares , Lingyun Rui , Luke B. Harris , Manami Shizuka , Michael Louis Miller , Ravi V.J. Chari
IPC分类号： C07K16/28 , A61K31/5517 , A61K47/68
CPC分类号： C07K16/28 , A61K31/5517 , A61K47/6803 , A61K47/6849 , A61K47/6851 , C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/515 , C07K2317/73
摘要： The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.
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公开(公告)号：US11420982B2
公开(公告)日：2022-08-23
申请号：US16991700
申请日：2020-08-12
申请人： IMMUNOGEN, INC.
IPC分类号： C07D487/04 , C07D519/00 , C07K5/083
摘要： The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
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公开(公告)号：US11116845B2
公开(公告)日：2021-09-14
申请号：US16901754
申请日：2020-06-15
申请人： IMMUNOGEN, INC.
IPC分类号： C07K5/02 , C07K5/093 , C07K5/113 , C07K16/28 , A61K39/00 , A61P35/00 , A61K47/64 , C07D487/04 , C07D519/00
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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公开(公告)号：US09381256B2
公开(公告)日：2016-07-05
申请号：US14843604
申请日：2015-09-02
申请人： ImmunoGen, Inc.
IPC分类号： A61K31/5517 , C07D519/00 , A61K47/48 , C07D487/04
CPC分类号： A61K47/6803 , A61K45/06 , A61K47/6845 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K2039/505 , C07D487/04 , C07D519/00 , C07K16/28 , C07K16/2863 , C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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公开(公告)号：US20230094471A1
公开(公告)日：2023-03-30
申请号：US17599347
申请日：2020-03-27
申请人： IMMUNOGEN, INC.
发明人： Ravi V.J. Chari , Michael Louis Miller , Manami Shizuka , Katie Elizabeth Archer , Emily Elizabeth Reid
摘要： The invention relates to benzodiazepine derivatives with antiproliferative activity and more specifically to benzodiazepine compounds of formulae (I), (II), (TI) and (T2). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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公开(公告)号：US20210292329A1
公开(公告)日：2021-09-23
申请号：US17186234
申请日：2021-02-26
申请人： IMMUNOGEN, INC.
IPC分类号： C07D487/04 , C07D209/12
摘要： The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic precursors. In an embodiment, the method discloses preparation of a compound represented by formula (III):
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公开(公告)号：US20210139510A1
公开(公告)日：2021-05-13
申请号：US17077688
申请日：2020-10-22
申请人： IMMUNOGEN, INC.
IPC分类号： C07D519/00 , C07C205/19 , C07D207/452 , C07D487/04 , C07D519/04
摘要： The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
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公开(公告)号：US10787463B2
公开(公告)日：2020-09-29
申请号：US16433117
申请日：2019-06-06
申请人： IMMUNOGEN, INC.
IPC分类号： C07D519/00 , C07D487/04 , C07K5/083
摘要： The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
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公开(公告)号：US10722588B2
公开(公告)日：2020-07-28
申请号：US16274665
申请日：2019-02-13
申请人： IMMUNOGEN, INC.
IPC分类号： C07D487/04 , A61K47/64 , C07K16/28 , C07D519/00 , C07K5/02 , C07K5/093 , C07K5/113 , A61K39/00
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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