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公开(公告)号:US20140309432A1
公开(公告)日:2014-10-16
申请号:US14261325
申请日:2014-04-24
申请人: Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
发明人: Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号: C07F5/02 , C07D491/052
CPC分类号: C07D491/052 , A61K31/4188 , A61K31/7056 , A61K31/7064 , A61K31/7072 , A61K38/06 , A61K38/07 , A61K38/21 , A61K45/06 , A61K47/60 , C07D405/12 , C07F5/025 , Y10S514/894 , A61K2300/00
摘要: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号:US20140018313A1
公开(公告)日:2014-01-16
申请号:US13884578
申请日:2011-11-16
申请人: Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
发明人: Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号: C07D403/14 , C07D491/113 , A61K31/4188 , C07D491/107 , A61K45/06 , A61K31/4184 , A61K31/5377
CPC分类号: C07D403/14 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D491/107 , C07D491/113 , C07D493/04 , C07D495/04 , C07D513/04 , A61K2300/00
摘要: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号:US08268802B2
公开(公告)日:2012-09-18
申请号:US12436004
申请日:2009-05-05
申请人: Xiaoqin Cheng , Gary P. Cook , Manoj C. Desai , Edward Doerffler , Gong-Xin He , Choung U. Kim , William A. Lee , John C. Rohloff , Jianying Wang , Zheng-Yu Yang
发明人: Xiaoqin Cheng , Gary P. Cook , Manoj C. Desai , Edward Doerffler , Gong-Xin He , Choung U. Kim , William A. Lee , John C. Rohloff , Jianying Wang , Zheng-Yu Yang
IPC分类号: C07F9/6561 , A61K31/675 , A61P31/20
CPC分类号: C07F9/65616 , Y02P20/55
摘要: Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1; RX1 and RX2 are independently RX; Y1 is ═O, —O(RX), ═S, —N(RX), —N(O)(RX), —N(ORX), —N(O)(ORX), or —N(N(RX)(RX)); RX is independently R1, R2, R4, W3, or a protecting group; R1 is independently —H or alkyl of 1 to 18 carbon atoms; R2 is independently R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R3 groups; R3 is R3a, R3b, R3c or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3c or R3d; R3a is —H, —F, —Cl, —Br, —I, —CF3, —CN, N3, —NO2, or —OR4; R3b is ═O, —O(R4), ═S, —N(R4), —N(O)(R4), —N(OR4), —N(O)(OR4), or —N(N(R4)(R4)); R3c is —R4, —N(R4)(R4), —SR4, —S(O)R4, —S(O)2R4, —S(O)(OR4), —S(O)2(OR4), —OC(R3b)R4, —OC(R3b)OR4, —OC(R3b)(N(R4)(R4)), —SC(R3b)R4, —SC(R3b)OR4, —SC(R3b)(N(R4)(R4)), —N(R4)C(R3b)R4, —N(R4)C(R3b)OR4, —N(R4)C(R3b) (N(R4)(R4)), W3 or —R5W3; R3d is —C(R3b)R4, —C(R3b)OR4, —C(R3b)W3, —C(R3b)OW3 or —C(R3b)(N(R4)(R4)); R4 is —H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W3 is W4 or W5; W4 is R6, —C(R3b)R6, —C(R3b)W5, —SOM2R6, or —SOM2W5, wherein R6 is R4 wherein each R4 is substituted with 0 to 3 R3 groups; W5 is carbocycle or heterocycle wherein W5 is independently substituted with 0 to 3 R2 groups; and M2 is 0, 1 or 2; and pharmaceutically acceptable salts thereof.
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公开(公告)号:US07837901B2
公开(公告)日:2010-11-23
申请号:US11475715
申请日:2006-06-27
申请人: Che-Hsiung Hsu , Christopher P. Junk , Frank P. Uckert , Mark F. Teasley , Andrew Edward Feiging , Charles J. Dubois , Natalie Daoud , Viascheslav A. Petrov , Zheng-Yu Yang , Amy Qi Han, legal representative
发明人: Che-Hsiung Hsu , Christopher P. Junk , Frank P. Uckert , Mark F. Teasley , Andrew Edward Feiging , Charles J. Dubois , Natalie Daoud , Viascheslav A. Petrov , Zheng-Yu Yang
CPC分类号: H01B1/127 , C08L23/26 , C08L65/00 , C08L73/02 , C09D165/00 , C09D179/02 , H01B1/128 , C08L2666/04 , C08L27/00
摘要: There are provided electrically conducting polymer compositions comprising an electrically conductive polymer or copolymer and an organic solvent wettable fluorinated acid polymer. Electrically conductive polymer materials are derived from thiophene, pyrrole, aniline and polycyclic heteroaromatic precursor monomers. Non-conductive polymers derived from alkenyl, alkynyl, arylene, and heteroarylene precursor monomers. The organic-solvent wettable fluorinated acid polymer is fluorinated or highly fluorinated and may be colloid-forming. Acidic groups include carboxylic acid groups, sulfonic acid groups, sulfonimide groups, phosphoric acid groups, phosphonic acid groups, and combinations thereof. The compositions can be used in organic electronic devices.
摘要翻译: 提供了包含导电聚合物或共聚物和有机溶剂可湿性氟化酸聚合物的导电聚合物组合物。 导电聚合物材料衍生自噻吩,吡咯,苯胺和多环杂芳族前体单体。 衍生自烯基,炔基,亚芳基和亚杂芳基前体单体的非导电聚合物。 有机溶剂可湿性氟化酸聚合物是氟化的或高度氟化的,可以是胶体形成。 酸性基团包括羧酸基团,磺酸基团,磺酰亚胺基团,磷酸基团,膦酸基团及其组合。 组合物可用于有机电子器件。
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公开(公告)号:US20050222090A1
公开(公告)日:2005-10-06
申请号:US11026303
申请日:2004-12-29
申请人: Xiaqin Cheng , Gary Cook , Manoj Desai , Edward Doerffler , Gong-Xin He , Choung Kim , William Lee , John Rohloff , Jianying Wang , Zheng-Yu Yang
发明人: Xiaqin Cheng , Gary Cook , Manoj Desai , Edward Doerffler , Gong-Xin He , Choung Kim , William Lee , John Rohloff , Jianying Wang , Zheng-Yu Yang
IPC分类号: A61K31/66 , A61K31/675 , C07F9/44 , C07F9/6561
CPC分类号: C07F9/65616 , Y02P20/55
摘要: Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1; RX1 and RX2 are independently RX; Y1 is ═O, —O(RX), ═S, —N(RX), —N(O)(RX), —N(ORX), —N(O)(ORX), or —N(N(RX)(RX)); RX is independently R1, R2, R4, W3, or a protecting group; R1 is independently —H or alkyl of 1 to 18 carbon atoms; R2 is independently R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R3 groups; R3 is R3a, R3b, R3c or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3c or R3d; R3a is —H, —F, —Cl, —Br, —I, —CF3, —CN, N3, —NO2, or —OR4; R3b is ═O, —O(R4), ═S, —N(R4), —N(O)(R4), —N(OR4), —N(O)(OR4), or —N(N(R4)(R4)); R3c is —R4, —N(R4)(R4), —SR4, —S(O)R4, —S(O)2R4, —S(O)(OR4), —S(O)2(OR4), —OC(R3b)R4, —OC(R3b)OR4, —OC(R3b)(N(R4)(R4)), —SC(R3b)R4, —SC(R3b)OR4, —SC(R3b)(N(R4)(R4)), —N(R4)C(R3b)R4, —N(R4)C(R3b)OR4, N(R4)C(R3b)(N(R4)(R4)), W3 or —R5W3; R3d is —C(R3b)R4, —C(R3b)OR4, —C(R3b)W3, —C(R3b)OW3 or —C(R3b)(N(R4)(R4)); R4 is —H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W3 is W4 or W5; W4 is R6, —C(R3b)R6, —C(R3b)W5, —SOM2R6, or —SOM2W5, wherein R6 is R4 wherein each R4 is substituted with 0 to 3 R3 groups; W5 is carbocycle or heterocycle wherein W5 is independently substituted with 0 to 3 R2 groups; and M2 is 0, 1 or 2; and pharmaceutically acceptable salts thereof.
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公开(公告)号:US06916831B2
公开(公告)日:2005-07-12
申请号:US10373399
申请日:2003-02-24
申请人: Kuo-Hsiung Lee , Yi Xia , Zheng-Yu Yang , Kenneth F. Bastow , Sheng-Chu Kuo
发明人: Kuo-Hsiung Lee , Yi Xia , Zheng-Yu Yang , Kenneth F. Bastow , Sheng-Chu Kuo
IPC分类号: C07D215/22 , C07D215/233 , A61K31/445 , A61K31/35 , C07D211/06 , C07D257/04 , C07D311/82
CPC分类号: C07D215/233
摘要: Compounds are described having a structure according to Formula I or Formula II: wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O and S; m is from 1 to 3; n is from 1 to 5; R1 and R3 are each independently selected from the group consisting of H, hydroxy, lower alky, lower alkoxy, halo, amino, aminoalkyl, nitro, heteroaryl, —OC(═O)R6, —O(C═O)OR6; and —O(C═O)N(R6)2; and R2 is side chain such as an acetic acid side chain, where p is O to 4, R5 is hydroxy, alkoxy or amino, and R6 is H or lower alkyl, or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer.
摘要翻译: 描述具有根据式I或式II的结构的化合物:其中:X选自O,NH和S; Y选自O和S; m为1〜3; n为1〜5; R 1和R 3各自独立地选自H,羟基,低级烷基,低级烷氧基,卤素,氨基,氨基烷基,硝基,杂芳基,-OC (-O)R 6,-O(CO)OR 6; 和-O(C-O)N(R 6)2。 并且R 2是侧链,例如乙酸侧链,其中p为0至4,R 5为羟基,烷氧基或氨基,R 6 或其低级烷基或其药学上可接受的盐。 该化合物可用于治疗癌症。
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公开(公告)号:US06569870B1
公开(公告)日:2003-05-27
申请号:US09669155
申请日:2000-09-25
申请人: Kuo-Hsiung Lee , Yi Xia , Zheng-Yu Yang , Sheno-Chu Kuo
发明人: Kuo-Hsiung Lee , Yi Xia , Zheng-Yu Yang , Sheno-Chu Kuo
IPC分类号: A61K3147
CPC分类号: C07D491/04 , C07D215/38
摘要: The present invention provides fluorinated quinolones which are fluorinated on the phenyl group thereof, along with pharmaceutical formulations containing the same, methods of treating tumors or cancer by the administration of such compounds, and methods of inhibiting cellular mitosis by the administration of such compounds.
摘要翻译: 本发明提供了在其苯基上氟化的氟化喹诺酮以及含有其的药物制剂,通过施用这些化合物治疗肿瘤或癌症的方法,以及通过施用这些化合物抑制细胞有丝分裂的方法。
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公开(公告)号:US20140112885A1
公开(公告)日:2014-04-24
申请号:US14049133
申请日:2013-10-08
申请人: Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
发明人: Elizabeth M. Bacon , Jeromy J. Cottell , Ashley Anne Katana , Darryl Kato , Evan S. Krygowski , John O. Link , James Taylor , Chinh Viet Tran , Teresa Alejandra Trejo Martin , Zheng-Yu Yang , Sheila Zipfel
IPC分类号: C07D491/052 , A61K31/7056 , A61K38/21 , A61K31/4188 , A61K45/06
CPC分类号: C07D491/052 , A61K31/4188 , A61K31/7056 , A61K31/7064 , A61K31/7072 , A61K38/06 , A61K38/07 , A61K38/21 , A61K45/06 , A61K47/60 , C07D405/12 , C07F5/025 , Y10S514/894 , A61K2300/00
摘要: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本公开涉及抗病毒化合物,含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US07998950B2
公开(公告)日:2011-08-16
申请号:US12509250
申请日:2009-07-24
申请人: Evangelos Aktoudianakis , Azim Alan Celebi , Zhimin Du , Salman Y. Jabri , Haolun Jin , Choung U. Kim , Jiayao Li , Samuel E. Metobo , Michael R. Mish , Barton W. Phillips , Joseph H. Saugier , Zheng-Yu Yang , Catalin Sebastian Zonte
发明人: Evangelos Aktoudianakis , Azim Alan Celebi , Zhimin Du , Salman Y. Jabri , Haolun Jin , Choung U. Kim , Jiayao Li , Samuel E. Metobo , Michael R. Mish , Barton W. Phillips , Joseph H. Saugier , Zheng-Yu Yang , Catalin Sebastian Zonte
IPC分类号: A61K31/55 , A61K31/5365 , A61K31/495 , A61K31/436 , C07D265/28 , C07D471/12 , C07D498/12
CPC分类号: C07D498/16 , C07D471/16
摘要: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译: 本发明涉及抗病毒化合物,含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号:US07723380B2
公开(公告)日:2010-05-25
申请号:US11880069
申请日:2007-07-19
申请人: Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
发明人: Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
IPC分类号: A61K31/343 , A61K31/443 , A61K31/427 , A61K31/41 , A61K31/4196 , C07D493/02 , C07D277/30 , C07D249/08 , C07D215/38 , C07D257/04 , C07D239/02
CPC分类号: C07D405/12 , C07D213/56 , C07D401/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D417/12 , C07D493/04 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要: The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译: 本发明涉及式I化合物或其药学上可接受的盐,溶剂合物,酯和/或膦酸盐,含有这些化合物的组合物,以及包括施用这些化合物的治疗方法。
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