2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
    9.
    发明申请
    2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT 有权
    2'-氟取代的CARBA-核苷类似物进行抗病毒治疗

    公开(公告)号:US20110070194A1

    公开(公告)日:2011-03-24

    申请号:US12885917

    申请日:2010-09-20

    CPC分类号: C07D487/04 C07H7/06 C07H13/08

    摘要: Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 2′ position of the nucleoside sugar is substituted with halogen and carbon substitutents. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections caused by both wild type and mutant strains of HCV.

    摘要翻译: 提供吡咯并[1,2-f] [1,2,4]三嗪基,咪唑并[1,5-f] [1,2,4]三嗪基,咪唑并[1,2-f] [1,2,4 ]三嗪基和[1,2,4]三唑并[4,3-f] [1,2,4]三嗪基核苷,其核苷磷酸酯和前药,其中核苷糖的2'位被卤素和碳 替代品 所提供的化合物,组合物和方法可用于治疗黄病毒科病毒感染,特别是HCV野生型和突变株引起的丙型肝炎感染。