发明申请
- 专利标题: PYRAZOLOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS
- 专利标题(中): 吡唑并吡啶化合物作为醛固酮合成酶抑制剂
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申请号: US14346518申请日: 2012-09-17
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公开(公告)号: US20140288094A1公开(公告)日: 2014-09-25
- 发明人: D. Jonathan Bennett , Jaiqiang Cai , Emma Carswell , Andrew Cooke , Scott B. Hoyt , Clare London , John MacLean , Min K. Park , Paul Ratcliffe , Yusheng Xiong , Swapan Kumar Samanta , Bheemashankar A. Kulkarni
- 申请人: MERCK SHARP & DOHME CORP
- 国际申请: PCT/US2012/055699 WO 20120917
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; A61K31/437 ; A61K31/519 ; C07D471/04
摘要:
This invention relates to pyrazolopyridyl compounds of the structural formula: or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.
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