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公开(公告)号：US09708336B2
公开(公告)日：2017-07-18
申请号：US15110431
申请日：2015-01-16
Applicant: Merck Sharp & Dohme Corp.
Inventor： Mihir Mandal , Haifeng Tang , Li Xiao , Jing Su , Guoqing Li , Shu-Wei Yang , Weidong Pan , Haiqun Tang , Reynalda DeJesus , Jacqueline Hicks , Matthew Lombardo , Hong Chu , William Hagmann , Alex Pasternak , Xin Gu , Jinlong Jiang , Shuzhi Dong , Fa-Xiang Ding , Clare London , Dipshikha Biswas , Katherine Young , David N. Hunter , Zhiqiang Zhao , Dexi Yang
IPC: C07D491/048 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D401/04 , C07D409/10 , C07D487/04 , C07D471/10 , C07D471/04 , C07D451/04 , C07D417/14 , C07D417/10 , C07D413/10 , C07D401/14 , C07D405/12 , C07D405/10 , C07D403/10 , C07D401/10 , C07D413/14 , C07D405/14 , A61K31/41 , C07D257/04 , A61K31/197 , A61K31/407 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427
CPC classification number: C07D491/048 , A61K31/197 , A61K31/407 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D257/04 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , Y02A50/473 , A61K2300/00
Abstract: The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
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公开(公告)号：US20160333021A1
公开(公告)日：2016-11-17
申请号：US15110431
申请日：2015-01-16
Applicant: Merck Sharp & Dohme Corp.
Inventor： Mihir Mandal , Haifeng Tang , Li Xiao , Jing Su , Guoqing Li , Shu-Wei Yang , Weidong Pan , Haiqun Tang , Reynalda DeJesus , Jacqueline Hicks , Matthew Lombardo , Hong Chu , William Hagmann , Alex Pasternak , Xin Gu , Jinlong Jiang , Shuzhi Dong , Fa-Xiang Ding , Clare London , Dipshikha Biswas , Katherine Young , David N. Hunter , Zhiqiang Zhao , Dexi Yang
IPC: C07D491/048 , A61K31/41 , A61K45/06 , A61K31/407 , A61K31/197 , C07D405/12 , A61K31/5377 , C07D403/10 , A61K31/4192 , A61K31/496 , C07D401/10 , A61K31/454 , A61K31/4439 , C07D409/10 , C07D417/10 , A61K31/427 , C07D405/14 , C07D413/10 , A61K31/422 , A61K31/506 , A61K31/497 , A61K31/4178 , A61K31/501 , A61K31/4155 , C07D471/04 , A61K31/437 , C07D417/14 , C07D401/14 , C07D487/04 , A61K31/5025 , A61K31/4245 , A61K31/541 , C07D401/04 , C07D413/14 , A61K31/55 , C07D471/10 , C07D257/04
CPC classification number: C07D491/048 , A61K31/197 , A61K31/407 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D257/04 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07D487/04 , Y02A50/473 , A61K2300/00
Abstract: The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
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