Invention Grant
- Patent Title: Metallo-beta-lactamase inhibitors
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Application No.: US15110431Application Date: 2015-01-16
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Publication No.: US09708336B2Publication Date: 2017-07-18
- Inventor: Mihir Mandal , Haifeng Tang , Li Xiao , Jing Su , Guoqing Li , Shu-Wei Yang , Weidong Pan , Haiqun Tang , Reynalda DeJesus , Jacqueline Hicks , Matthew Lombardo , Hong Chu , William Hagmann , Alex Pasternak , Xin Gu , Jinlong Jiang , Shuzhi Dong , Fa-Xiang Ding , Clare London , Dipshikha Biswas , Katherine Young , David N. Hunter , Zhiqiang Zhao , Dexi Yang
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Alysia A. Finnegan; Gloria M. Fuentes
- International Application: PCT/US2015/011735 WO 20150116
- International Announcement: WO2015/112441 WO 20150730
- Main IPC: C07D491/048
- IPC: C07D491/048 ; A61K31/437 ; A61K31/4439 ; A61K31/454 ; A61K31/496 ; A61K31/497 ; A61K31/501 ; A61K31/5025 ; A61K31/506 ; A61K31/5377 ; A61K31/541 ; A61K31/55 ; A61K45/06 ; C07D401/04 ; C07D409/10 ; C07D487/04 ; C07D471/10 ; C07D471/04 ; C07D451/04 ; C07D417/14 ; C07D417/10 ; C07D413/10 ; C07D401/14 ; C07D405/12 ; C07D405/10 ; C07D403/10 ; C07D401/10 ; C07D413/14 ; C07D405/14 ; A61K31/41 ; C07D257/04 ; A61K31/197 ; A61K31/407 ; A61K31/4155 ; A61K31/4178 ; A61K31/4192 ; A61K31/422 ; A61K31/4245 ; A61K31/427
Abstract:
The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
Public/Granted literature
- US20160333021A1 METALLO-BETA-LACTAMASE INHIBITORS Public/Granted day:2016-11-17
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