-
1.发明授权公开(公告)号：US09877957B2
公开(公告)日：2018-01-30
申请号：US15508557
申请日：2015-08-31
发明人： Jason Imbriglio , Clare London , Zhijian Lu , James Tata , Yusheng Xiong , Ming You , Hyewon Youm
IPC分类号： C07D217/06 , A61K31/47 , C07C13/04 , A61K31/16 , C07D417/12
CPC分类号： A61K31/47 , A61K31/16 , C07C13/04 , C07D217/06 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardio renal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
-
2.发明申请公开(公告)号：US20170273965A1
公开(公告)日：2017-09-28
申请号：US15508550
申请日：2015-08-31
发明人： Jason Imbriglio , Rui Liang , Clare London , Kenneth Marby , James Tata , Ming You , Yusheng Xiong
IPC分类号： A61K31/47 , A61K31/16 , C07C13/04 , C07D217/06
CPC分类号： A61K31/47 , A61K31/16 , C07C13/04 , C07D217/06 , C07D401/04 , C07D401/06 , C07D401/10 , C07D411/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula (I) are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
-
3.发明授权公开(公告)号：US10568876B2
公开(公告)日：2020-02-25
申请号：US15508550
申请日：2015-08-31
发明人： Jason Imbriglio , Rui Liang , Clare London , Kenneth Marby , James Tata , Ming You , Yusheng Xiong
IPC分类号： C07D413/12 , A61K31/47 , C07D217/06 , A61K31/16 , C07C13/04
摘要： The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula (I) are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
-
4.发明申请公开(公告)号：US20170273966A1
公开(公告)日：2017-09-28
申请号：US15508557
申请日：2015-08-31
发明人： Jason Imbriglio , Clare London , Zhijian Lu , James Tata , Yusheng Xiong , Ming You , Hyewon Youm
IPC分类号： A61K31/47 , C07C13/04 , A61K31/16 , C07D217/06
CPC分类号： A61K31/47 , A61K31/16 , C07C13/04 , C07D217/06 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention relates to a compound represented by formula I:and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardio renal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
-
公开(公告)号：US09828369B2
公开(公告)日：2017-11-28
申请号：US15508562
申请日：2015-08-31
申请人： Merck Sharp & Dohme Corp. , Jason Imbriglio , Clare London , Zhijian Lu , James Tata , Yusheng Xiong , Ming You , Hye Won Youm
发明人： Jason Imbriglio , Clare London , Zhijian Lu , James Tata , Yusheng Xiong , Ming You , Hyewon Youm
IPC分类号： C07D217/02 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/12 , C07D413/12
CPC分类号： C07D417/12 , A61K45/06 , A61P9/10 , C07D217/02 , C07D217/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12
摘要： The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardio-renal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
-
公开(公告)号：US20170275274A1
公开(公告)日：2017-09-28
申请号：US15508562
申请日：2015-08-31
申请人： Jason IMBRIGLIO , Clare LONDON , Zhijian LU , James TATA , Yusheng XIONG , Ming YOU , Hye Won YOUM , Merck Sharp & Dohme Corp.
发明人： Jason Imbriglio , Clare London , Zhijian Lu , James Tata , Yusheng Xiong , Ming You , Hyewon Youm
IPC分类号： C07D417/12 , C07D217/02 , C07D401/04 , C07D405/12 , C07D401/14 , C07D413/12 , C07D401/12
CPC分类号： C07D417/12 , A61K45/06 , A61P9/10 , C07D217/02 , C07D217/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12
摘要： The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardio-renal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.016 秒)
