发明授权
- 专利标题： Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
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申请号： US15508562申请日： 2015-08-31
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公开(公告)号： US09828369B2公开(公告)日： 2017-11-28
- 发明人: Jason Imbriglio , Clare London , Zhijian Lu , James Tata , Yusheng Xiong , Ming You , Hyewon Youm
- 申请人： Merck Sharp & Dohme Corp. , Jason Imbriglio , Clare London , Zhijian Lu , James Tata , Yusheng Xiong , Ming You , Hye Won Youm
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharpe & Dohme Corp.
- 当前专利权人： Merck Sharpe & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Eric A. Meade; Catherine D. Fitch
- 国际申请： PCT/US2015/047659 WO 20150831
- 国际公布： WO2016/036638 WO 20160310
- 主分类号： C07D217/02
- IPC分类号： C07D217/02 ; C07D401/04 ; C07D401/12 ; C07D401/14 ; C07D405/12 ; C07D417/12 ; C07D413/12
摘要：
The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardio-renal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
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