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    GLOBAL GERM LINE AND TUMOR MICROSATELLITE PATTERNS ARE CANCER BIOMARKERS
    12.
    发明申请
    GLOBAL GERM LINE AND TUMOR MICROSATELLITE PATTERNS ARE CANCER BIOMARKERS 审中-公开
    全球前线和肿瘤微阵列图案是癌症生物标志物

    公开(公告)号：US20100317534A1

    公开(公告)日：2010-12-16

    申请号：US12814294

    申请日：2010-06-11

    Applicant: Harold R. Garner

    Inventor： Harold R. Garner

    IPC: C40B30/00 ,  C12Q1/68

    CPC classification number: C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

    Abstract: The present invention includes a method of identifying an increase in microsatellite DNA from a genomic nucleic acid sample comprising: obtaining a microsatellite profile from a sample suspected of comprising cancer cells; comparing the microsatellite profile to a reference microsatellite profile from a reference genome; and determining in increase in the number of microsatellite DNAs from the sample as compared to the reference genome, wherein an increase in microsatellite DNA indicates a pre-disposition to cancer and the microsatellites are upstream from the estrogen receptor-related gamma gene (ESRRG).

    Abstract translation: 本发明包括鉴定来自基因组核酸样品的微卫星DNA增加的方法，包括：从怀疑包含癌细胞的样品获得微卫星谱; 将微卫星轮廓与参考基因组的参考微卫星轮廓进行比较; 并且与参考基因组相比，确定来自样品的微卫星DNA数量的增加，其中微卫星DNA的增加表明癌症的预处理，并且微卫星位于雌激素受体相关γ基因（ESRRG）的上游。

    Micropipette adaptor for spectrophotometers
    15.
    发明授权
    Micropipette adaptor for spectrophotometers 失效
    用于分光光度计的微量移液器适配器

    公开(公告)号：US4991958A

    公开(公告)日：1991-02-12

    申请号：US377476

    申请日：1989-07-10

    Applicant: Harold R. Garner

    Inventor： Harold R. Garner

    IPC: G01N21/03 ,  B01L3/02 ,  G01N21/01 ,  G01N21/27 ,  G01N21/59 ,  G01N35/00 ,  G01N35/10

    CPC classification number: B01L3/021 ,  G01N21/01 ,  G01N2021/0346 ,  G01N2035/00237 ,  G01N2035/1062

    Abstract: An adaptor for holding a micropipette in a spectrophotometer includes a base member for holding the micropipette and an optical system for linearly focusing visible or ultraviolet light onto the micropipette. Specifically, the optical system includes a cylindrical lens which focuses collimated light from a light source into a line along the axis of the micropipette. The optical system also includes a cylindrical quartz lens which recollimates the light that has passed through the micropipette sample holder. A detector is provided to receive the recollimated light for measuring the absorptivity of the sample material held in the micropipette.

    Detecting strain in birefringent materials using spectral polarimetry
    17.
    发明授权
    Detecting strain in birefringent materials using spectral polarimetry 失效
    使用光谱极化法检测双折射材料中的应变

    公开(公告)号：US07859653B2

    公开(公告)日：2010-12-28

    申请号：US11848284

    申请日：2007-08-31

    Applicant: Anthony J. Ragucci ,  Alan J. Cisar ,  Michael L. Huebschman ,  Harold R. Garner

    Inventor： Anthony J. Ragucci ,  Alan J. Cisar ,  Michael L. Huebschman ,  Harold R. Garner

    IPC: G01B11/16

    CPC classification number: G01B11/168 ,  G01J3/2823 ,  G01J3/447

    Abstract: A method, computer program product and system for analyzing multispectral images from a plurality of regions of birefringent material, such as a polymer film, using polarized light and a corresponding polar analyzer to identify differential strain in the birefringent material. For example, the birefringement material may be low-density polyethylene (LDPE), high-density polyethylene (HDPE), polypropylene, polyethylene terephthalate (PET), polyvinyl chloride (PVC), polyvinylidene chloride, polyester, nylon, or cellophane film. Optionally, the method includes generating a real-time quantitative strain map.

    Abstract translation: 一种用于从双折射材料的多个区域（例如聚合物膜）使用偏振光和相应的极性分析仪分析多光谱图像以识别双折射材料中的微分应变的方法，计算机程序产品和系统。 例如，双折射材料可以是低密度聚乙烯（LDPE），高密度聚乙烯（HDPE），聚丙烯，聚对苯二甲酸乙二醇酯（PET），聚氯乙烯（PVC），聚偏二氯乙烯，聚酯，尼龙或玻璃纸膜。 可选地，该方法包括生成实时定量应变图。

    Automatic sequencer/genotyper having extended spectral response
    19.
    发明授权
    Automatic sequencer/genotyper having extended spectral response 失效
    自动定序器/ genotyper具有扩展的光谱响应

    公开(公告)号：US5871628A

    公开(公告)日：1999-02-16

    申请号：US702767

    申请日：1996-08-22

    Applicant: Ali Dabiri ,  Harold R. Garner

    Inventor： Ali Dabiri ,  Harold R. Garner

    IPC: G01N27/447 ,  G01N27/26

    CPC classification number: G01N27/44721 ,  B01J2219/00702

    Abstract: An advanced imaging spectrograph system provides for slab-gel DNA sequencing and genotyping with high throughput sequencing. The system is based on the integration of improved electrophoresis structures with an imaging spectrophotometer that records the entire emission spectra along an imaging line across a sequencing gel (or capillary array). The system includes spectral shape matching to improve dye identification allowing the use of dyes having nearly any emission spectra and allowing greater than four dye multiplexing.

    Abstract translation: 先进的成像光谱仪系统提供板状凝胶DNA测序和高通量测序的基因分型。 该系统基于改进的电泳结构与成像分光光度计的整合，其通过测序凝胶（或毛细管阵列）沿着成像线记录整个发射光谱。 该系统包括光谱形状匹配以改善染料鉴定，允许使用具有几乎任何发射光谱并允许大于四种染料复合的染料。

    Micropipette adaptor with temperature control for PCR amplification
    20.
    发明授权
    Micropipette adaptor with temperature control for PCR amplification 失效
    具有PCR扩增温度控制的微量适配器

    公开(公告)号：US5241363A

    公开(公告)日：1993-08-31

    申请号：US843443

    申请日：1992-02-28

    Applicant: Harold R. Garner

    Inventor： Harold R. Garner

    IPC: B01L3/02 ,  B01L7/00 ,  G01N21/01 ,  G01N21/03 ,  G01N35/00 ,  G01N35/10 ,  G05D23/22

    CPC classification number: G01N21/01 ,  B01L3/021 ,  B01L7/00 ,  G01N21/0332 ,  G05D23/22 ,  G01N2021/0346 ,  G01N2035/00237 ,  G01N2035/1062

    Abstract: A temperature-controlled micropipette adaptor includes a metal base sandwiched between two plastic layers. The metal base has an orifice to hold a micropipette. The plastic layers hold lenses in alignment for spectrophotometric measurements of a sample contained in a micropipette inserted into the orifice. A resistive heater wire or thermoelectric heater/cooler is held between the metal base and the plastic layer to transfer heat from the heater wire or thermoelectric device to the metal base and thus to the micropipette sample. A thermocouple is attached to the metal layer to monitor temperature changes. A feedback control system is coupled to the device for monitoring and programmably controlling changes in temperature of the heated sample over time. As desired, a microprocessor can be electrically connected between the heater wire or thermoelectric device and the output signal of the spectrophotometer to selectively energize the heater wire thermoelectric device in response to the output signal of the spectrophotometer.

    Abstract translation: 温度控制的微量移液器适配器包括夹在两个塑料层之间的金属基底。 金属底座具有用于容纳微量移液管的孔口。 塑料层将透镜对准，以便分光光度测量包含在插入孔中的微量移液管中的样品。 电阻加热器线或热电加热器/冷却器保持在金属基底和塑料层之间，以将热量从加热丝或热电装置传递到金属基底，从而传递到微量吸管样品。 热电偶连接到金属层以监测温度变化。 反馈控制系统耦合到该装置，用于随时间监视和可编程地控制加热样品的温度变化。 根据需要，微处理器可以电连接在加热丝或热电装置与分光光度计的输出信号之间，以响应于分光光度计的输出信号选择性地激励加热线热电装置。

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