公开(公告)号：US09913603B2

公开(公告)日：2018-03-13

申请号：US14621286

申请日：2015-02-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Sameer Walavalkar ,  Chieh-feng Chang ,  Axel Scherer ,  Brandon Marin ,  Scott E. Fraser ,  Andrea R. Tao

IPC: G01N21/65 ,  G01N33/18 ,  G01N33/483 ,  G01N33/00 ,  A61B5/1459 ,  H01L27/146 ,  A61B5/1473 ,  A61B5/07 ,  A61B5/00 ,  B82Y40/00 ,  B82Y30/00

CPC classification number: A61B5/1459 ,  A61B5/0075 ,  A61B5/076 ,  A61B5/14735 ,  A61B5/6848 ,  A61B5/686 ,  A61B2562/0233 ,  A61B2562/0285 ,  A61B2562/12 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/658 ,  H01L27/14698

Abstract: Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.

公开(公告)号：US09846125B2

公开(公告)日：2017-12-19

申请号：US14621295

申请日：2015-02-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Sameer Walavalkar ,  Axel Scherer ,  Thomas A. Tombrello

IPC: G01N21/65 ,  G01N33/00 ,  G01N33/18 ,  G01N33/483 ,  A61B5/00

CPC classification number: G01N21/658 ,  A61B5/00 ,  A61B5/0031 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/686 ,  G01N33/0004 ,  G01N33/18 ,  G01N33/483

Abstract: Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.

公开(公告)号：US09406823B2

公开(公告)日：2016-08-02

申请号：US14329748

申请日：2014-07-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Andrew P. Homyk ,  Michael D. Henry ,  Axel Scherer ,  Sameer Walavalkar

IPC: H01L29/06 ,  H01L31/0352 ,  B82Y10/00 ,  H01L29/66 ,  H01L29/775 ,  H01L33/06 ,  B82Y40/00 ,  H01L29/12 ,  H01L29/41 ,  H01L21/02 ,  H01L29/267

CPC classification number: H01L31/035227 ,  B82Y10/00 ,  B82Y40/00 ,  H01L21/02381 ,  H01L21/0243 ,  H01L21/02521 ,  H01L21/0259 ,  H01L21/02639 ,  H01L29/0665 ,  H01L29/0676 ,  H01L29/127 ,  H01L29/267 ,  H01L29/413 ,  H01L29/66439 ,  H01L29/775 ,  H01L33/06 ,  Y10S977/762

Abstract: Methods for fabricating self-aligned heterostructures and semiconductor arrangements using silicon nanowires are described.

Abstract translation: 描述了使用硅纳米线制造自对准异质结构和半导体布置的方法。

公开(公告)号：US09243277B2

公开(公告)日：2016-01-26

申请号：US14753741

申请日：2015-06-29

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya Rajagopal ,  Axel Scherer ,  Michael D. Henry ,  Sameer Walavalkar ,  Thomas A. Tombrello ,  Andrew P. Homyk

IPC: G01R1/067 ,  G01R31/00 ,  C12Q1/02 ,  H01L29/78 ,  H01L29/66 ,  G01N27/327 ,  G01N27/414 ,  A61B5/04 ,  H01L29/41 ,  H01L29/423 ,  H01L29/49 ,  G01R1/073

CPC classification number: C12Q1/02 ,  A61B5/04001 ,  G01N27/3275 ,  G01N27/4146 ,  G01R1/06711 ,  G01R1/07342 ,  H01L29/413 ,  H01L29/42376 ,  H01L29/4966 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7831

Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.

公开(公告)号：US09099436B2

公开(公告)日：2015-08-04

申请号：US13852476

申请日：2013-03-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya Rajagopal ,  Axel Scherer ,  Michael D. Henry ,  Sameer Walavalkar ,  Thomas A. Tombrello ,  Andrew P. Homyk

IPC: G01R1/067 ,  H01L29/423 ,  H01L29/78 ,  H01L29/66 ,  G01N27/327 ,  G01N27/414 ,  A61B5/04 ,  H01L29/41 ,  H01L29/49 ,  G01R1/073

CPC classification number: C12Q1/02 ,  A61B5/04001 ,  G01N27/3275 ,  G01N27/4146 ,  G01R1/06711 ,  G01R1/07342 ,  H01L29/413 ,  H01L29/42376 ,  H01L29/4966 ,  H01L29/66477 ,  H01L29/78 ,  H01L29/7831

Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.

Abstract translation: 本文公开的探针的基本结构和功能允许灵活地并入到探针中，用于各种感测应用的各种感测元件。 这些各种感测应用中的两个示例应用包括生物感测和化学感测应用。 对于生物感测应用，制造在硅衬底上的探针包括诸如纳米柱晶体管的生物感测元件，并且对于化学感测应用，探针包括具有功能化接触区域的感测元件， 当暴露于感兴趣的一种或多种化学品时，感测元件产生电压。

公开(公告)号：US20130327645A1

公开(公告)日：2013-12-12

申请号：US13967108

申请日：2013-08-14

Applicant: California Institute of Technology

Inventor： Sameer Walavalkar ,  Axel Scherer ,  Thomas A. Tombrello ,  Aditya Rajagopal ,  Andrew P. Homyk ,  Erika Garcia

IPC: G01N27/447

CPC classification number: G01N27/447 ,  B82Y30/00 ,  C12Q1/6869 ,  G01N33/48721 ,  C12Q2563/116 ,  C12Q2565/631

Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.

Abstract translation: 本文公开了用于测序核酸的方法和装置。 本文还提供了用于测量具有大小允许DNA穿过纳米孔的纳米孔的DNA的装置。 可以测量通过纳米孔的DNA分子的电容。 电容测量可以相关，以确定通过纳米孔的碱基对序列来对DNA进行排序。