公开(公告)号：US20090227672A1

公开(公告)日：2009-09-10

申请号：US12339494

申请日：2008-12-19

Applicant: David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

Inventor： David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

IPC: A61K31/215 ,  A61K31/192 ,  A61P27/06

CPC classification number: A61K31/559 ,  A61K31/381 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  C07C35/21 ,  C07C215/42 ,  C07C235/34 ,  C07C247/10 ,  C07C255/36 ,  C07C405/00 ,  C07C2601/08 ,  Y10S514/913

Abstract: The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compound. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.

Abstract translation: 本发明提供环戊烷庚酸，2-环烷基或芳基烷基化合物，其可以在1-位被氨基，酰氨基，醚或酯基取代，例如1-OH环戊烷庚酸，2-（环烷基或芳烷基 ）化合物。 本发明的环戊烷庚酸2-（环烷基或芳基烷基）化合物是有效的眼部低血压剂，特别适用于治疗青光眼。 此外，本发明的环戊烷庚酸，2-（环烷基或芳基烷基）化合物是广泛应用于全身高血压和肺部疾病的平滑肌松弛剂; 平滑肌松弛剂适用于胃肠道疾病，繁殖，生育，失禁，休克等。

公开(公告)号：US07531665B2

公开(公告)日：2009-05-12

申请号：US10829139

申请日：2004-04-20

Applicant: Steven W. Andrews ,  Michael E. Garst ,  Xialing Guo ,  Jonathan J. Hebert ,  Thomas Malone ,  Julie A. Wurster ,  Clarence Eugene Hull, III

Inventor： Steven W. Andrews ,  Michael E. Garst ,  Xialing Guo ,  Jonathan J. Hebert ,  Thomas Malone ,  Julie A. Wurster ,  Clarence Eugene Hull, III

IPC: C07D401/14

CPC classification number: C07D403/06 ,  C07D209/34 ,  C07D405/04

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract translation: 本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。

公开(公告)号：US20090111969A1

公开(公告)日：2009-04-30

申请号：US12341683

申请日：2008-12-22

Applicant: Lawrence M. Blatt ,  Steven W. Andrews ,  Kevin R. Condroski ,  George A. Doherty ,  Yutong Jiang ,  John A. Josey ,  April L. Kennedy ,  Machender R. Madduru ,  Peter J. Stengel ,  Steven M. Wenglowsky ,  Benjamin T. Woodard ,  Laura Woodard

Inventor： Lawrence M. Blatt ,  Steven W. Andrews ,  Kevin R. Condroski ,  George A. Doherty ,  Yutong Jiang ,  John A. Josey ,  April L. Kennedy ,  Machender R. Madduru ,  Peter J. Stengel ,  Steven M. Wenglowsky ,  Benjamin T. Woodard ,  Laura Woodard

IPC: C07K5/00

CPC classification number: C07K5/0804

Abstract: The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

公开(公告)号：US20090105471A1

公开(公告)日：2009-04-23

申请号：US12341971

申请日：2008-12-22

Applicant: Lawrence M. Blatt ,  Steven W. Andrews ,  Kevin R. Condroski ,  George A. Doherty ,  Yutong Jiang ,  John A. Josey ,  April L. Kennedy ,  Machender R. Madduru ,  Peter J. Stengel ,  Steven M. Wenglowsky ,  Benjamin T. Woodard ,  Laura Woodard

Inventor： Lawrence M. Blatt ,  Steven W. Andrews ,  Kevin R. Condroski ,  George A. Doherty ,  Yutong Jiang ,  John A. Josey ,  April L. Kennedy ,  Machender R. Madduru ,  Peter J. Stengel ,  Steven M. Wenglowsky ,  Benjamin T. Woodard ,  Laura Woodard

IPC: C07D225/04 ,  C07D245/04

CPC classification number: C07K5/0804

Abstract: The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

公开(公告)号：US20090047246A1

公开(公告)日：2009-02-19

申请号：US12029399

申请日：2008-02-11

Applicant: Leonid Beigelman ,  Brad Buckman ,  Vladimir Serebryany ,  Guangyi Wang ,  Jasenka Matulic-Adamic ,  Antitsa Dimitrova Stoycheva ,  Steven W. Andrews ,  Shawn Maurice Misialek ,  P.T. Ravi Rajagopalan ,  Andrew M. Fryer ,  Indrani Gunawardana ,  Julia Haas ,  Lily Huang ,  Machender R. Madduru ,  Gan Zhang ,  Karl Kossen ,  Scott D. Seiwert ,  Lawrence M. Blatt

Inventor： Leonid Beigelman ,  Brad Buckman ,  Vladimir Serebryany ,  Guangyi Wang ,  Jasenka Matulic-Adamic ,  Antitsa Dimitrova Stoycheva ,  Steven W. Andrews ,  Shawn Maurice Misialek ,  P.T. Ravi Rajagopalan ,  Andrew M. Fryer ,  Indrani Gunawardana ,  Julia Haas ,  Lily Huang ,  Machender R. Madduru ,  Gan Zhang ,  Karl Kossen ,  Scott D. Seiwert ,  Lawrence M. Blatt

IPC: A61K38/21 ,  C07D409/06 ,  A61K31/405 ,  A61K31/506 ,  C07D403/08 ,  A61K31/404 ,  C07D209/20 ,  A61K31/675 ,  C07F9/572 ,  A61K31/437 ,  C07D471/02 ,  C12N9/99 ,  A61K31/44 ,  A61K39/395 ,  A61K31/427 ,  C12N9/50 ,  C12N9/00 ,  C12Q1/68 ,  G01N33/53

CPC classification number: C07F9/65583 ,  C07D209/18 ,  C07D209/30 ,  C07D209/32 ,  C07D307/79 ,  C07D333/60 ,  C07D401/10 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D407/06 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06 ,  C07D413/10 ,  C07D417/06 ,  C07D487/04 ,  C07F9/5728 ,  C12Q1/707 ,  G01N2333/186 ,  G01N2333/914

Abstract: The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Abstract translation: 实施方案提供了通式I的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

公开(公告)号：US06765012B2

公开(公告)日：2004-07-20

申请号：US10256879

申请日：2002-09-27

Applicant: Steven W. Andrews ,  Julie A. Wurster ,  Edward H. Wang ,  Thomas Malone

Inventor： Steven W. Andrews ,  Julie A. Wurster ,  Edward H. Wang ,  Thomas Malone

IPC: A61K31435

CPC classification number: C07D295/088 ,  A61K31/404 ,  C07D209/34 ,  C07D295/135 ,  C07D401/10 ,  C07D403/12

Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Abstract translation: 本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。

公开(公告)号：US06403649B1

公开(公告)日：2002-06-11

申请号：US09519834

申请日：2000-03-06

Applicant: David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

Inventor： David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

IPC: A61K31135

CPC classification number: A61K31/559 ,  A61K31/381 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  C07C35/21 ,  C07C215/42 ,  C07C235/34 ,  C07C247/10 ,  C07C255/36 ,  C07C405/00 ,  C07C2601/08 ,  Y10S514/913

Abstract: The present invention provides cydopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cydopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compound. The cydopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cydopentane heptanoic, 2-(cycloalkyl or arylalkyl) compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.

Abstract translation: 本发明提供环戊烷庚酸，2-环烷基或芳基烷基化合物，其可以在1-位被氨基，酰氨基，醚或酯基取代，例如1-OH环戊烷庚酸，2-（环烷基或芳烷基 ）化合物。 本发明的环戊烷庚酸2-（环烷基或芳基烷基）化合物是有效的眼部低血压剂，特别适用于治疗青光眼。 此外，本发明的环戊烷庚酸，2-（环烷基或芳基烷基）化合物是广泛应用于全身高血压和肺部疾病的平滑肌松弛剂; 平滑肌松弛剂适用于胃肠道疾病，繁殖，生育，失禁，休克等。

公开(公告)号：US5688819A

公开(公告)日：1997-11-18

申请号：US605567

申请日：1996-02-22

Applicant: David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

Inventor： David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

IPC: A61K31/557 ,  A61K31/5575 ,  C07C35/21 ,  C07C215/42 ,  C07C235/34 ,  C07C247/10 ,  C07C255/36 ,  C07C405/00 ,  A61K31/135 ,  A61K31/34 ,  A61K31/38 ,  A61K31/44

CPC classification number: A61K31/559 ,  A61K31/557 ,  A61K31/5575 ,  C07C215/42 ,  C07C235/34 ,  C07C247/10 ,  C07C255/36 ,  C07C35/21 ,  C07C405/00 ,  C07C2101/08

Abstract: The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compound. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.

Abstract translation: 本发明提供环戊烷庚酸，2-环烷基或芳基烷基化合物，其可以在1位被氨基，酰胺基，醚或酯基取代，例如1-OH环戊烷庚酸，2-（环烷基或芳烷基 ）化合物。 本发明的环戊烷庚酸2-（环烷基或芳基烷基）化合物是有效的眼部低血压剂，特别适用于治疗青光眼。 此外，本发明的环戊烷庚酸，2-（环烷基或芳基烷基）化合物是广泛应用于全身高血压和肺部疾病的平滑肌松弛剂; 平滑肌松弛剂适用于胃肠道疾病，繁殖，生育，失禁，休克等。

公开(公告)号：US5387608A

公开(公告)日：1995-02-07

申请号：US108209

申请日：1993-08-17

Applicant: Steven W. Andrews

Inventor： Steven W. Andrews

IPC: C07D309/12 ,  A61K31/55 ,  A61K31/557 ,  A61K31/5575 ,  A61P27/02 ,  C07C311/13 ,  C07C405/00 ,  A61K31/215 ,  A61K31/195 ,  C07C69/74

CPC classification number: C07C311/13 ,  C07C405/0041 ,  Y10S514/913

Abstract: The present invention relates to cyclopentane heptanoic or cyclopentane heptenoic acid, 2-hydrocarbyl sulfonamidomethyl, and derivatives thereof, useful as therapeutic agents. In particular, the therapeutic agents of this invention are useful as ocular hypotensives.

Abstract translation: 本发明涉及可用作治疗剂的环戊烷庚酸或环戊烷庚烯酸，2-烃基磺酰胺基甲基及其衍生物。 特别地，本发明的治疗剂可用作眼睛低血压剂。

公开(公告)号：US5352708A

公开(公告)日：1994-10-04

申请号：US948056

申请日：1992-09-21

Applicant: David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

Inventor： David F. Woodward ,  Steven W. Andrews ,  Robert M. Burk ,  Michael E. Garst

IPC: A61K31/045 ,  A61K31/075 ,  A61K31/13 ,  A61K31/16 ,  A61K31/275 ,  A61K31/381 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  A61K31/655 ,  A61P1/00 ,  A61P1/16 ,  A61P9/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P27/02 ,  A61P27/06 ,  A61P27/14 ,  A61P37/08 ,  A61P43/00 ,  C07C35/21 ,  C07C35/50 ,  C07C69/732 ,  C07C69/734 ,  C07C205/17 ,  C07C215/42 ,  C07C235/34 ,  C07C247/10 ,  C07C255/36 ,  C07C405/00

CPC classification number: A61K31/559 ,  A61K31/381 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/5585 ,  C07C215/42 ,  C07C235/34 ,  C07C247/10 ,  C07C255/36 ,  C07C35/21 ,  C07C405/00 ,  C07C2101/08

Abstract: The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime, cyano, thiol, either or thioether groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivatives of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) derivatives of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.

Abstract translation: 本发明提供在1-位被卤素，甲基，羟基，硝基，氨基，酰氨基，叠氮基，肟，氰基，硫醇，或硫醚基取代的环戊烷庚酸，2-环烷基或芳基烷基衍生物，例如 1-OH环戊烷庚酸，2-（环烷基或芳基烷基）衍生物。 本发明的环戊烷庚酸，2-（环烷基或芳基烷基）衍生物是有效的眼睛低血压剂，特别适用于治疗青光眼。 此外，本发明的环戊烷庚酸，2-（环烷基或芳基烷基）衍生物是广泛应用于全身高血压和肺部疾病的平滑肌松弛剂; 平滑肌松弛剂适用于胃肠道疾病，繁殖，生育，失禁，休克等。