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公开(公告)号：US09707561B2
公开(公告)日：2017-07-18
申请号：US15038024
申请日：2014-11-19
Applicant: Randox Laboratories Ltd.
Inventor： Jonathan Matear , Robson Pang , Stuart Jackson , David Sloan
CPC classification number: B01L3/50273 , B01L3/502715 , B01L3/527 , B01L2200/027 , B01L2200/04 , B01L2200/0605 , B01L2200/0621 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/123 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , F04B9/042 , G01N35/00029 , G01N35/1002 , G01N2035/00148 , G01N2035/0486
Abstract: There is provided an assay fluid delivery system comprising an array of fluid reservoirs (62), each of which is selectively actuatable to deliver a respective fluid to a fluid channel structure; and a fluid delivery control system (50) comprising a plurality of reciprocally mounted actuators, each associated with a respective reservoir and being movable between a retracted position and an actuating position at which it causes fluid to be delivered from the corresponding reservoir, a plurality of cams (22) with different profiles mounted on a common, rotatable cam shaft (6), each cam being engaged with a respective one of the actuators whereby rotation of the cams causes movement of the corresponding actuators between the retracted and actuating positions, and a motor coupled to the cam shaft for rotating the cam shaft, wherein the cams are shaped relative to one another so as to cause the corresponding actuators to actuate the reservoirs in a predetermined sequence and for predetermined respective times.
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公开(公告)号：US20170176476A1
公开(公告)日：2017-06-22
申请号：US15385063
申请日：2016-12-20
Applicant: Randox Laboratories Limited
Inventor： Ivan McConnell , Elouard Benchikh , Philip Lowry , Peter Fitzgerald
IPC: G01N33/94 , C07K16/44 , G01N33/543
CPC classification number: G01N33/9486 , C07K16/44 , C07K2317/33 , G01N33/54366
Abstract: An immunoassay method is described which detects O-desmethyltramadol only. This enables an assay of high sensitivity and specificity avoiding false positive results. The unique antibodies incorporated in the immunoassay method can be combined with antibodies which detect mitragynine to provide an assay which increases the possibility of detecting the commonly found drug combination of O-desmethyltramadol and mitragynine.
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公开(公告)号：US09671415B2
公开(公告)日：2017-06-06
申请号：US14874047
申请日：2015-10-02
Applicant: RANDOX LABORATORIES LIMITED
Inventor： Ivan McConnell , Peter Fitzgerald , Philip Lowry , Elouard Benchikh
CPC classification number: G01N33/94 , C07K16/44 , C07K2317/33 , G01N33/946
Abstract: The current invention provides an improved immunoassay for the detection and determination of pyrrolidinophenone based designer drugs in hair and biological fluids (urine, blood, and oral fluid). The generic immunoassay is underpinned by novel, sub-family-specific antibodies, which display surprising sensitivity. The invention further describes substrates comprising an antibody that is specific to compounds of the pyrrolidinophenone family. Also described are the novel immunogens from which the antibodies are derived and kits incorporating the antibodies of the current invention.
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公开(公告)号：US20160266153A1
公开(公告)日：2016-09-15
申请号：US15067979
申请日：2016-03-11
Applicant: Randox Laboratories Limited
Inventor： Elouard Benchikh , Ivan McConnell , Peter Fitzgerald , Philip Lowry
IPC: G01N33/94 , C07K1/107 , C07K16/44 , C07K14/765 , C07K14/435
CPC classification number: G01N33/9426 , C07K1/1077 , C07K14/43504 , C07K14/765 , C07K16/44
Abstract: Antibodies, immunoassay methods and kits thereof are described for the detection and determination of 3-(aminomethyl)-5-methylhexanoic acid. The novel immunogens from which said antibodies are generated are also described.
Abstract translation: 描述了用于检测和测定3-（氨基甲基）-5-甲基己酸的抗体，免疫测定方法和试剂盒。 还描述了产生所述抗体的新型免疫原。
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公开(公告)号：US20160266020A1
公开(公告)日：2016-09-15
申请号：US15036811
申请日：2014-11-13
Applicant: RANDOX LABORATORIES LTD
Inventor： Michael Veitinger , Maria Zellner
CPC classification number: G01N1/4077 , C12Q1/485 , G01N33/6842 , G01N33/86
Abstract: The present invention provides a novel method of in vitro sample preparation for the analysis of proteins. In a first aspect, the present invention is a method comprising the separation and individual treatment of blood platelets and platelet-poor plasma obtained from a platelet-rich plasma sample. This allows for optimal treatment of both fractions and overcomes many of the problems associated with current methods. In a second aspect of the present invention the platelet sample preparation method can be implemented before a biochip based immunoassay for the detection of platelet proteins in combination with plasma proteins.
Abstract translation: 本发明提供了用于分析蛋白质的体外样品制备的新方法。 在第一方面，本发明是一种包括从富含血小板的血浆样品中分离和单独处理血小板和血小板不足血浆的方法。 这允许对两个级分进行最佳处理并克服与当前方法相关的许多问题。 在本发明的第二方面，血小板样品制备方法可以在用于检测与血浆蛋白质组合的血小板蛋白质的基于生物芯片的免疫测定之前实施。
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Patent Agency Ranking
16.发明申请BIOMARKER-BASED METHODS AND BIOCHIPS FOR AIDING THE DIAGNOSIS OF STROKE 审中-公开基于生物标记的方法和生物技术用于帮助诊断诊断公开(公告)号：US20150126385A1
公开(公告)日：2015-05-07
申请号：US14361880
申请日：2012-12-03
Applicant: Randox Laboratories Ltd.
Inventor： John Lamont , Ivan Mc Connell , Peter Fitzgerald
IPC: G01N33/68
CPC classification number: G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N33/6842 , G01N2333/4737 , G01N2333/5412 , G01N2333/70503 , G01N2333/70525 , G01N2333/70542 , G01N2333/70564 , G01N2333/7151 , G01N2800/2871 , G01N2800/32 , G01N2800/60
Abstract: The present invention provides biomarker-based methods for diagnosing stroke in a patient suspected of having suffered a stroke, and also for discriminating between ischemic stroke and transient ischemic attack. Substrates comprising probes for specific combinations of biomarkers useful in the methods of the invention are also described.
Abstract translation: 本发明提供了用于诊断疑似患有中风的患者的中风的基于生物标志物的方法，并且还用于区分缺血性卒中和短暂性脑缺血发作。 还描述了包含用于本发明方法中的生物标志物的特定组合的探针的底物。
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公开(公告)号：US20150118763A1
公开(公告)日：2015-04-30
申请号：US14536163
申请日：2014-11-07
Applicant: RANDOX LABORATORIES LIMITED
Inventor： STEPHEN PETER FITZGERALD , PAUL JOHN INNOCENZI , IVAN ROBERT McCONNELL , PHILIP ANDREW LOWRY , ELOUARD BENCHIKH
CPC classification number: G01N33/948 , C07K16/44 , C07K17/14 , Y10S435/81
Abstract: The invention describes methods and kits for detecting and determining current and future synthetic cannabinoids from the JWH and CP families. Unique antibodies derived from novel immunogens enable said methods and kits.
Abstract translation: 本发明描述了用于从JWH和CP家族中检测和确定当前和未来的合成大麻素的方法和试剂盒。 衍生自新型免疫原的独特抗体能够实现所述方法和试剂盒。
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公开(公告)号：US20150098937A1
公开(公告)日：2015-04-09
申请号：US14323775
申请日：2014-07-03
Applicant: Randox Laboratories Ltd.
Inventor： JOHN V. LAMONT
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , A61K31/404 , A61K31/4439 , A61K31/517 , C12Q2600/106 , C12Q2600/156
Abstract: The present disclosure provides a method for identifying whether a subject is more or less likely to be responsive to VEGF-based therapy, comprising screening a nucleic acid sample obtained from the subject to provide output information which identifies the presence or absence of an allelic variant, wherein the presence or absence of an allelic variant indicates whether the subject is more or less likely to be responsive to VEGF-based therapy.
Abstract translation: 本公开提供了用于鉴定受试者是或多或少可能对基于VEGF的治疗有反应的方法，其包括筛选从受试者获得的核酸样品以提供识别等位变体的存在或不存在的输出信息， 其中等位基因变体的存在或不存在表明受试者是或多或少可能对基于VEGF的治疗有反应。
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公开(公告)号：US20140099651A1
公开(公告)日：2014-04-10
申请号：US14048325
申请日：2013-10-08
Applicant: Randox Laboratories
Inventor： Ivan McConnell , Elouard Benchikh , Philip Lowry , Peter Fitzgerald
CPC classification number: G01N33/94 , A61K47/643 , A61K47/646 , C07K16/44 , C07K2317/33
Abstract: The invention provides novel haptens and immunogens for the preparation of novel monoclonal antibodies, which detect the synthetic opioid meperidine and its active metabolite normeperidine. These antibodies enable methods and kits, which are useful in an immunoassay for therapeutic drug monitoring (TDM) and in extending the window of detection for cases of abuse and drug-facilitated sexual assault (DFSA).
Abstract translation: 本发明提供新型的半抗原和免疫原，用于制备新的单克隆抗体，其检测合成的阿片样哌啶及其活性代谢标准哌啶。 这些抗体使得方法和试剂盒可用于治疗药物监测（TDM）的免疫测定和延长滥用和药物促进性攻击（DFSA）检测窗口。
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公开(公告)号：US20040191890A1
公开(公告)日：2004-09-30
申请号：US10643926
申请日：2003-08-20
Applicant: RANDOX LABORATORIES LTD
Inventor： James Rudolf Meyer , Ahti Kalevi Kansanaho , Stephen Peter Fitzgerald , Robert Ivan McConnell , John Victor Lamont , Bailin Cao
IPC: C12M001/34
CPC classification number: G01N35/028 , G01N35/00029 , G01N35/0099 , G01N2035/00158 , G01N2035/00326 , G01N2035/0425 , Y10T436/113332
Abstract: An assay device processing instrument comprises a plurality of processing modules. A transport system transports an assay device to each processing module, the transport system being adapted to transfer the assay device from the transport system to the module to enable the transport system to transport another assay device while the first is processed by the processing module. A control system controls operation of the transport system such that each assay device is transferred between the modules in a predetermined sequence, and such that a number of assay devices can be processed in different modules simultaneously.
Abstract translation: 测定装置处理装置包括多个处理模块。 运输系统将测定装置运送到每个处理模块，所述运输系统适于将测定装置从运输系统传送到模块，以使得运输系统能够在第一个由处理模块处理的同时运送另一个测定装置。 控制系统控制运输系统的操作，使得每个测定装置以预定顺序在模块之间转移，并且使得可以同时在不同模块中处理多个测定装置。
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