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公开(公告)号：US10737088B2
公开(公告)日：2020-08-11
申请号：US15123557
申请日：2015-03-02
IPC分类号： A61M39/24 , A61M11/06 , A61M15/00 , A61M16/16 , B05B7/14 , F16K15/14 , A61M16/20 , A61M16/00 , F16K15/18 , G01N21/53 , A61M16/08 , A61M16/14 , A61M16/10 , B05B1/32
摘要： The invention relates to a device (10) for providing an aerosol from an aerosolizable material, the device comprising an aerosolization unit (300) through which pressure pulses of a carrier gas (60) are passed; a reservoir (100) comprising the aerosolizable material and which provides the aerosolizable material to the aerosolization unit (300) where the aerosolizable material is entrained by the carrier gas (60); a material providing valve (210) located between the reservoir (100) and the aerosolization unit (300) which opens in direction of the aerosolization unit (300) and which is opened and closed by a pressure difference between the reservoir (100) and the aerosolization unit (300) and which provides, in an open state, the aerosolizable material to the aerosolization unit (300).
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公开(公告)号：US10377987B2
公开(公告)日：2019-08-13
申请号：US14563474
申请日：2014-12-08
发明人： Jens Altrichter , Steffen Mitzner , Antje Lübcke , Kathleen Selleng , Fanny Doss , Stephanie Koch
IPC分类号： A61K35/16 , C12N5/0783
摘要： A method for preparing a leukocyte preparation from a leukocyte fraction and a correspondingly prepared or obtainable leukocyte preparation and its use. The method includes: a) sedimenting the leukocyte fraction removing leukocyte supernatant from the sediment, wherein the leukocyte supernatant is collected or remains in a leukocyte container, b) sedimenting the leukocytes in the leukocyte container, c) washing the sediment in the leukocyte container with a saline solution, and d) resuspending the sediment in the leukocyte container in a storage solution.
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公开(公告)号：US20190206713A1
公开(公告)日：2019-07-04
申请号：US16224017
申请日：2018-12-18
发明人： Richard Reiner , Thomas Gerrer , Dirk Meder , Beatrix Weiss , Patrick Waltereit
IPC分类号： H01L21/683 , H01L21/02 , H01L23/13 , H01L23/538 , H01L23/373 , H01L23/15 , H01L29/20
CPC分类号： H01L21/6835 , H01L21/02381 , H01L21/02458 , H01L21/0254 , H01L23/13 , H01L23/15 , H01L23/3731 , H01L23/3732 , H01L23/5384 , H01L23/5386 , H01L23/5389 , H01L29/2003 , H01L2221/68363 , H01L2221/68381
摘要： A method for producing a semiconductor device is provided. A growth substrate having a first side and an opposite second side is provided. At least one electronic component is produced by depositing and/or structuring at least one layer on the first side of the growth substrate, said layer containing or consisting of at least one compound semiconductor. The first side of the electronic component that is opposite the first side of the growth substrate is connected to a support. The growth substrate is removed. The support has at least one feed-through and/or at least one conductor track, which is connected to at least one terminal contact of the electronic component. Alternatively or in addition, a semiconductor device produced in this way and a support having such a semiconductor device may be provided.
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公开(公告)号：US20190032969A1
公开(公告)日：2019-01-31
申请号：US16061154
申请日：2016-12-09
发明人： Kilian Bartholome , Jan Horzella , Andreas Mahlke , Jan Konig , Marc Vergez
IPC分类号： F25B23/00
摘要： A method for operating cyclic process-based systems, with a hot-side reservoir (1) and a cold-side reservoir (2) for a fluid (3), and at least one heat exchanger unit (4) with mechanocaloric material, wherein the mechanocaloric material of the heat exchanger unit (4) is actively connected to the fluid (3) such that heat is transferred between the mechanocaloric material and the fluid (3). It is essential that the transfer of heat between the mechanocaloric material and the fluid (3) takes place essentially by latent heat transfer. A corresponding heat-transfer unit (4) and a corresponding apparatus are also provided.
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公开(公告)号：US20180041001A1
公开(公告)日：2018-02-08
申请号：US15555409
申请日：2016-03-02
发明人： Oliver De Vries , Jens Limpert , Marco Plotner
摘要： The invention relates to a method for generating a laser pulse train, comprising the following method steps: generating the laser pulse train (4a) at a pulse repetition frequency; coupling the laser pulse train (4a) into an acousto-optical modulator, and selecting individual laser pulses of the laser pulse train (4a) by driving the acousto-optical modulator with high-frequency pulses (4h), wherein the high-frequency pulses (4h) are generated by modulating a high-frequency carrier signal (4f) with a periodic switching signal (4e). In addition, the invention relates to a system for generating a laser pulse train, comprising a pulsed laser (1), which generates the laser pulse train at a pulse repetition frequency, and an acousto-optical modulator (2), in which the laser pulses propagate, and comprising a control device (7), which drives the acousto-optical modulator (2) with high-frequency pulses for the purpose of selecting individual laser pulses. It is an object of the invention to provide an improved method for selecting individual laser pulses from a laser pulse train. The intensity noise known from the prior art is intended to be reduced. The invention achieves this object by virtue of the fact that the following holds true for the frequency fHF of the carrier signal (4f) of the high-frequency pulses (4h): fHF=n/p·fPRF, wherein n is an arbitrary natural number and p indicates the integral ratio between the pulse repetition frequency and the frequency of the switching signal (4e), and wherein the carrier signal (4f) is coupled to the laser pulse train (4a) in a phase-stable manner.
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公开(公告)号：US20180030414A1
公开(公告)日：2018-02-01
申请号：US15661035
申请日：2017-07-27
申请人： Stephan FRICKE , Frank EMMRICH , Nadja HILGER
发明人： Stephan FRICKE , Frank EMMRICH , Nadja HILGER
CPC分类号： C12N5/0669 , A61K35/28 , A61K2035/124 , A61K2039/505 , C07K16/2812 , C12N5/0087 , C12N5/0648
摘要： The present invention relates to, among others, an in vitro method of modifying a cell graft containing immune cells comprising the steps of incubating a cell graft containing immune cells with an anti CD4 antibody wherein said incubating is carried out for from 1 minute to 7 days, b) removing unbound antibody from said graft; as well as to corresponding modified grafts and uses. The invention further relates to the modification of antibodies reactive to the CD4 human leukocyte antigen to provide anti-CD4 antibodies that have a reduced number of potential T-cell epitopes but retain the ability to bind to CD4, such as to an anti human CD4-antibody comprising a heavy chain immunoglobulin variable domain (VH) and a light chain immunoglobulin variable domain (VL), wherein at least one T cell epitope located outside the CDRs of said immunoglobulin variable domains is removed from said immunoglobulin variable domains. Preferably, the specificity and mode of action of the anti-CD4 antibodies are not affected by the modification(s).
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17.发明授权公开(公告)号：US09879657B2
公开(公告)日：2018-01-30
申请号：US14440188
申请日：2013-10-15
发明人： Michael Haupt , Christian Oehr
IPC分类号： F03D5/02 , F03D11/00 , B05D1/00 , F03D1/06 , B05D5/08 , F03D80/40 , B64D15/00 , B64C11/20 , B05D5/02
CPC分类号： F03D80/40 , B05D1/62 , B05D5/02 , B05D5/083 , B64C11/205 , B64D15/00 , F03D1/0675 , F05B2230/90 , Y02E10/721 , Y02P70/523
摘要： The present invention relates to rotor blades of devices, particularly of wind turbines, having an anti-ice coating, as well as to methods for their production and their use.
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公开(公告)号：US20170302047A1
公开(公告)日：2017-10-19
申请号：US15515961
申请日：2015-10-01
申请人： Fraunhofer-Gesellschaft zur Forderung der angewandten Forschung e.V. , Friedrich-Schiller-Universitat Jena
CPC分类号： G02B6/1221 , G02B6/0011 , G02B6/4296 , G02B27/1006 , H01S3/0405 , H01S3/042 , H01S3/06708 , H01S3/06716 , H01S3/06729 , H01S3/06733 , H01S3/06737 , H01S3/094007 , H01S3/1643 , H01S3/2383
摘要： The invention relates to an optical waveguide with at least one core region (1) extending along the longitudinal extent of the optical waveguide, and with a first jacket (2) which, viewed in the cross section of the optical waveguide, surrounds the core region (1). The invention further relates to an optical arrangement with such an optical waveguide, and to a method for producing the optical waveguide. The object of the invention is to make available an optical waveguide for high-performance operation, which is improved in relation to the prior art in terms of mode instability. The invention achieves this object by virtue of the fact that the optical waveguide consists of crystalline material at least in the core region (1).
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公开(公告)号：US09752814B2
公开(公告)日：2017-09-05
申请号：US14047570
申请日：2013-10-07
发明人： Uwe Schon , Heiko Zimmermann , Guenter Fuhr
CPC分类号： F25D3/10 , A01N1/02 , A01N1/0257 , B01L7/00 , F25D29/001 , F25D2700/12 , G01N1/42
摘要： The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, including a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating performance (P2) for heating the coolant (3) delivered to the cooling chamber (1), a first temperature sensor (8-10) for measuring the temperature (T2-T4) in the cooling chamber (1), a second temperature sensor (7) for measuring the temperature (Ti) of the coolant (3) delivered to the cooling chamber (I), and a regulator (11) for regulating the temperature. The regulator (11) is embodied as a multiple regulator which detects several temperatures (T1-T4) as control variables and/or adjusts several heating performances (P1, P2) as manipulated variables. The invention further relates to a corresponding operating method.
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公开(公告)号：US09622471B2
公开(公告)日：2017-04-18
申请号：US10580300
申请日：2004-11-17
CPC分类号： A01N25/34 , A01N25/10 , A01N59/16 , A01N59/20 , A61L15/18 , A61L15/26 , A61L15/44 , A61L27/306 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2420/02 , A61L2420/08 , A01N25/32 , A01N2300/00
摘要： The invention relates to an antimicrobial and preferably non-cytotoxic coating material and to use of said coating material.
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