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    FREE NGAL AS A BIOMARKER FOR CANCER
    144.
    发明申请
    FREE NGAL AS A BIOMARKER FOR CANCER 审中-公开
    免费NGAL作为癌症的生物标记

    公开(公告)号：US20110081650A1

    公开(公告)日：2011-04-07

    申请号：US12756501

    申请日：2010-04-08

    申请人： Marsha A. Moses ,  Jiang Yang

    发明人： Marsha A. Moses ,  Jiang Yang

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/57496 ,  G01N33/57415 ,  G01N33/57449 ,  G01N33/57488 ,  G01N2333/47

    摘要： Uncomplexed neutrophil gelatinase associated lipocalin (NGAL) is present at increased levels in individuals with atypical ductal hyperplasia (ADH), a major risk factor for future breast cancer development; in individuals that have ovarian cancer; and in individuals that have breast cancer, both invasive and noninvasive. Accordingly, the present invention is directed to measuring uncomplexed NGAL levels in urine as a primary screen to determine if an individual is either at risk of developing, or has developed cancer, e.g., cancer of epithelial origin including breast and ovarian cancer.

    摘要翻译： 未复合的嗜中性粒细胞明胶酶相关脂质运载蛋白（NGAL）以增加的水平存在于具有非典型导管增生（ADH）的个体中，这是未来乳腺癌发展的主要风险因素; 卵巢癌患者; 以及具有乳腺癌的个体，既有创伤性又有侵袭性。 因此，本发明涉及测量尿液中未复合的NGAL水平作为主要屏幕，以确定个体是否处于发展的风险中，或已经发展为癌症，例如包括乳腺癌和卵巢癌在内的上皮癌症。

    REPLICATION PROTEIN
    145.
    发明申请
    REPLICATION PROTEIN 审中-公开
    复制蛋白

    公开(公告)号：US20110070591A1

    公开(公告)日：2011-03-24

    申请号：US12888238

    申请日：2010-09-22

    申请人： Dawn COVERLEY

    发明人： Dawn COVERLEY

    IPC分类号： G01N33/566 ,  C12Q1/68

    CPC分类号： G01N33/57496 ,  C07K14/4702 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57426 ,  G01N33/5743 ,  G01N33/57438 ,  G01N2333/47

    摘要： This invention relates to a screening method for the identification of agents which modulate the activity of a DNA replication protein as a target for intervention in cancer therapy and includes agents which modulate said activity. The invention also relates to the use of the DNA replication protein, and its RNA transcripts in the prognosis and diagnosis of proliferative disease e.g., cancer.

    摘要翻译： 本发明涉及一种筛选方法，用于鉴定调节作为癌症治疗干预的靶标的DNA复制蛋白的活性的试剂，并且包括调节所述活性的试剂。 本发明还涉及DNA复制蛋白及其RNA转录物在增殖性疾病例如癌症的预后和诊断中的用途。

    In-vivo monitoring of circulating apoptotic cells
    150.
    发明授权
    In-vivo monitoring of circulating apoptotic cells 有权
    循环凋亡细胞的体内监测

    公开(公告)号：US07745155B2

    公开(公告)日：2010-06-29

    申请号：US11190729

    申请日：2005-07-27

    申请人： Charles P. Lin ,  Xunbin Wei ,  Dorothy Sipkins

    发明人： Charles P. Lin ,  Xunbin Wei ,  Dorothy Sipkins

    IPC分类号： G01N33/574 ,  G01N21/00 ,  G01N21/66 ,  A61K49/00

    CPC分类号： A61K49/0032 ,  A61K49/0056 ,  A61K49/0097 ,  G01N33/56966 ,  G01N33/57496 ,  G01N33/582 ,  G01N2510/00 ,  G01N2800/52 ,  Y10T436/101666 ,  Y10T436/13

    摘要： The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe molecules. The labeled cells are irradiated in-vivo so as to excite the fluorescent probes, and the radiation emitted by the excited probes is detected, preferably confocally. The detected radiation is then analyzed to derive desired information, such as relative cell count, of the cells of interest. In some embodiments, the circulating cells comprise apoptotic cells whose detection can allow, e.g., non-invasive monitoring of the efficacy of a cancer treatment, such as an anti-tumor or an anti-angiogenic therapy.

    摘要翻译： 本发明提供用于进行体内流式细胞术的方法和系统。 在一个实施方案中，用荧光探针分子标记受试者感兴趣的选定的循环细胞。 将标记的细胞体内照射以激发荧光探针，并且检测被激发的探针发射的辐射，优选共方。 然后分析所检测的辐射以获得感兴趣的细胞的所需信息，例如相对细胞计数。 在一些实施方案中，循环细胞包含凋亡细胞，其检测可以允许例如非侵入性监测癌症治疗（例如抗肿瘤或抗血管生成治疗）的功效。