公开(公告)号：US20110070591A1

公开(公告)日：2011-03-24

申请号：US12888238

申请日：2010-09-22

申请人： Dawn COVERLEY

发明人： Dawn COVERLEY

IPC分类号： G01N33/566 ,  C12Q1/68

CPC分类号： G01N33/57496 ,  C07K14/4702 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57426 ,  G01N33/5743 ,  G01N33/57438 ,  G01N2333/47

摘要： This invention relates to a screening method for the identification of agents which modulate the activity of a DNA replication protein as a target for intervention in cancer therapy and includes agents which modulate said activity. The invention also relates to the use of the DNA replication protein, and its RNA transcripts in the prognosis and diagnosis of proliferative disease e.g., cancer.

摘要翻译： 本发明涉及一种筛选方法，用于鉴定调节作为癌症治疗干预的靶标的DNA复制蛋白的活性的试剂，并且包括调节所述活性的试剂。 本发明还涉及DNA复制蛋白及其RNA转录物在增殖性疾病例如癌症的预后和诊断中的用途。