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公开(公告)号：US09309515B2
公开(公告)日：2016-04-12
申请号：US14128152
申请日：2011-08-10
申请人： Jung Hwan Lee , Young Chan Chae , Youngdong Kim , Hyungu Kang , Jong Hun Im , Jong In Kim , Ki Seok Kim , Sung Key Jang , Il Ung Oh , Min Jeong Choi , Won Jun Kang
发明人： Jung Hwan Lee , Young Chan Chae , Youngdong Kim , Hyungu Kang , Jong Hun Im , Jong In Kim , Ki Seok Kim , Sung Key Jang , Il Ung Oh , Min Jeong Choi , Won Jun Kang
IPC分类号： C12N15/11 , C12N15/115 , A61K31/7088 , G01N33/574 , A61K47/48
CPC分类号： C12N15/115 , A61K31/7088 , A61K47/60 , C12N2310/16 , C12N2310/335 , C12N2310/3535 , C12N2320/30 , G01N33/5748 , G01N2333/71 , G01N2333/91205
摘要： Disclosed are a DNA aptamer specifically binding to the Her2 (ERBB2) receptor involved in the onset of breast cancer, a composition for the suppression of cancer metastasis comprising the same as an active ingredient, and a composition for the diagnosis of cancer comprising the same as an active ingredient. Due to its binding mechanism being different from that of the conventional antibody, the aptamer can be effectively used for suppressing cancer metastasis and diagnosing cancer.
摘要翻译： 公开了特异性结合参与乳腺癌发病的Her2（ERBB2）受体的DNA适体，用于抑制与其相同的活性成分的癌症转移的组合物，以及用于诊断癌症的组合物，其包含与 活性成分。 由于其结合机理与常规抗体的结合机制不同，适体可以有效地用于抑制癌症转移和诊断癌症。
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2.发明申请公开(公告)号：US20150005368A1
公开(公告)日：2015-01-01
申请号：US14128152
申请日：2011-08-10
申请人： Jung Hwan Lee , Young Chan Chae , Youndong Kim , Hyungu Kang , Jong Hun Im , Jong In Kim , Ki Seok Kim , Sung Key Jang , II Ung Oh , Min Jeong Choi , Won Jun Kang
发明人： Jung Hwan Lee , Young Chan Chae , Youndong Kim , Hyungu Kang , Jong Hun Im , Jong In Kim , Ki Seok Kim , Sung Key Jang , II Ung Oh , Min Jeong Choi , Won Jun Kang
IPC分类号： C12N15/115 , G01N33/574
CPC分类号： C12N15/115 , A61K31/7088 , A61K47/60 , C12N2310/16 , C12N2310/335 , C12N2310/3535 , C12N2320/30 , G01N33/5748 , G01N2333/71 , G01N2333/91205
摘要： Disclosed are a DNA aptamer specifically binding to the Her2 (ERBB2) receptor involved in the onset of breast cancer, a composition for the suppression of cancer metastasis comprising the same as an active ingredient, and a composition for the diagnosis of cancer comprising the same as an active ingredient. Due to its binding mechanism being different from that of the conventional antibody, the aptamer can be effectively used for suppressing cancer metastasis and diagnosing cancer.
摘要翻译： 公开了特异性结合参与乳腺癌发病的Her2（ERBB2）受体的DNA适体，用于抑制与其相同的活性成分的癌症转移的组合物，以及用于诊断癌症的组合物，其包含与 活性成分。 由于其结合机理与常规抗体的结合机制不同，适体可以有效地用于抑制癌症转移和诊断癌症。
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公开(公告)号：US20110262922A1
公开(公告)日：2011-10-27
申请号：US13092209
申请日：2011-04-22
申请人： Young-Chan CHAE , Youn-Dong Kim , Jung-Hwan Lee , Ki-Seok Kim , Dong-II Han , Bum-Su Park , Seung-Jin Lee , Jong-Hun Im , Jong-In Kim , Sung-Ho Ryu , Sung-Key Jang
发明人： Young-Chan CHAE , Youn-Dong Kim , Jung-Hwan Lee , Ki-Seok Kim , Dong-II Han , Bum-Su Park , Seung-Jin Lee , Jong-Hun Im , Jong-In Kim , Sung-Ho Ryu , Sung-Key Jang
CPC分类号： G01N33/5308
摘要： The present invention provides methods for identifying the plurality of aptamers that bind to different sites of a target molecule and methods for using the same, for example, in sandwich assays. In particular, the plurality of aptamers binding to different sites of the target molecules is identified from a library of aptamers identified from the same SELEX process.
摘要翻译： 本发明提供用于鉴定结合靶分子的不同位点的多个适体的方法以及使用其的方法，例如在夹心测定中。 特别地，从相同SELEX过程鉴定的适配体文库中鉴定结合靶分子不同位点的多个适体。
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公开(公告)号：US20100317723A1
公开(公告)日：2010-12-16
申请号：US12759813
申请日：2010-04-14
申请人： JUNG-HWAN LEE , SOON-HAG KIM , MI-JIN KWON , HYUN-GU KANG , SUNG-HO RYU , JONG-IN KIM , YOUN-DONG KIM , YOUNG-CHAN CHAE , SUNG-KEY JANG , JONG-HUN IM , SUN-HAK LEE , HYE-JUNG LEE , EUN-JUNG JANG , KI-SEOK KIM
发明人： JUNG-HWAN LEE , SOON-HAG KIM , MI-JIN KWON , HYUN-GU KANG , SUNG-HO RYU , JONG-IN KIM , YOUN-DONG KIM , YOUNG-CHAN CHAE , SUNG-KEY JANG , JONG-HUN IM , SUN-HAK LEE , HYE-JUNG LEE , EUN-JUNG JANG , KI-SEOK KIM
CPC分类号： G01N33/57496 , C12N15/115 , C12N2310/16 , C12N2310/335
摘要： Improved G-rich oligonucleotide (GRO) aptamers specific to nucleolin, a method of preparing the aptamers, and a use of the aptamers for diagnosing and/or treating a nucleolin-associated disease, are provided.
摘要翻译： 提供了改进的对核仁林特异性的富G寡核苷酸（GRO）适配体，制备适体的方法，以及适配体用于诊断和/或治疗核仁素相关疾病的用途。
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公开(公告)号：US08785132B2
公开(公告)日：2014-07-22
申请号：US13092209
申请日：2011-04-22
申请人： Young-Chan Chae , Youn-Dong Kim , Jung-Hwan Lee , Ki-Seok Kim , Dong-II Han , Bum-Su Park , Seung-Jin Lee , Jong-Hun Im , Jong-In Kim , Sung-Ho Ryu , Sung-Key Jang
发明人： Young-Chan Chae , Youn-Dong Kim , Jung-Hwan Lee , Ki-Seok Kim , Dong-II Han , Bum-Su Park , Seung-Jin Lee , Jong-Hun Im , Jong-In Kim , Sung-Ho Ryu , Sung-Key Jang
CPC分类号： G01N33/5308
摘要： The present invention provides methods for identifying the plurality of aptamers that bind to different sites of a target molecule and methods for using the same, for example, in sandwich assays. In particular, the plurality of aptamers binding to different sites of the target molecules is identified from a library of aptamers identified from the same SELEX process.
摘要翻译： 本发明提供用于鉴定结合靶分子的不同位点的多个适体的方法以及使用其的方法，例如在夹心测定中。 特别地，从相同SELEX过程鉴定的适配体文库中鉴定结合靶分子不同位点的多个适体。
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公开(公告)号：US08569252B2
公开(公告)日：2013-10-29
申请号：US12759813
申请日：2010-04-14
申请人： Jung-Hwan Lee , Soon-Hag Kim , Mi-Jin Kwon , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Youn-Dong Kim , Young-Chan Chae , Sung-Key Jang , Jong-Hun Im , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang , Ki-Seok Kim
发明人： Jung-Hwan Lee , Soon-Hag Kim , Mi-Jin Kwon , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Youn-Dong Kim , Young-Chan Chae , Sung-Key Jang , Jong-Hun Im , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang , Ki-Seok Kim
IPC分类号： C12N15/11
CPC分类号： G01N33/57496 , C12N15/115 , C12N2310/16 , C12N2310/335
摘要： Improved G-rich oligonucleotide (GRO) aptamers specific to nucleolin, a method of preparing the aptamers, and a use of the aptamers for diagnosing and/or treating a nucleolin-associated disease, are provided.
摘要翻译： 提供了改进的对核仁林特异性的富G寡核苷酸（GRO）适配体，制备适体的方法，以及适配体用于诊断和/或治疗核仁素相关疾病的用途。
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