公开(公告)号：US09309515B2

公开(公告)日：2016-04-12

申请号：US14128152

申请日：2011-08-10

申请人： Jung Hwan Lee ,  Young Chan Chae ,  Youngdong Kim ,  Hyungu Kang ,  Jong Hun Im ,  Jong In Kim ,  Ki Seok Kim ,  Sung Key Jang ,  Il Ung Oh ,  Min Jeong Choi ,  Won Jun Kang

发明人： Jung Hwan Lee ,  Young Chan Chae ,  Youngdong Kim ,  Hyungu Kang ,  Jong Hun Im ,  Jong In Kim ,  Ki Seok Kim ,  Sung Key Jang ,  Il Ung Oh ,  Min Jeong Choi ,  Won Jun Kang

IPC分类号： C12N15/11 ,  C12N15/115 ,  A61K31/7088 ,  G01N33/574 ,  A61K47/48

CPC分类号： C12N15/115 ,  A61K31/7088 ,  A61K47/60 ,  C12N2310/16 ,  C12N2310/335 ,  C12N2310/3535 ,  C12N2320/30 ,  G01N33/5748 ,  G01N2333/71 ,  G01N2333/91205

摘要： Disclosed are a DNA aptamer specifically binding to the Her2 (ERBB2) receptor involved in the onset of breast cancer, a composition for the suppression of cancer metastasis comprising the same as an active ingredient, and a composition for the diagnosis of cancer comprising the same as an active ingredient. Due to its binding mechanism being different from that of the conventional antibody, the aptamer can be effectively used for suppressing cancer metastasis and diagnosing cancer.

摘要翻译： 公开了特异性结合参与乳腺癌发病的Her2（ERBB2）受体的DNA适体，用于抑制与其相同的活性成分的癌症转移的组合物，以及用于诊断癌症的组合物，其包含与 活性成分。 由于其结合机理与常规抗体的结合机制不同，适体可以有效地用于抑制癌症转移和诊断癌症。

公开(公告)号：US20150005368A1

公开(公告)日：2015-01-01

申请号：US14128152

申请日：2011-08-10

申请人： Jung Hwan Lee ,  Young Chan Chae ,  Youndong Kim ,  Hyungu Kang ,  Jong Hun Im ,  Jong In Kim ,  Ki Seok Kim ,  Sung Key Jang ,  II Ung Oh ,  Min Jeong Choi ,  Won Jun Kang

发明人： Jung Hwan Lee ,  Young Chan Chae ,  Youndong Kim ,  Hyungu Kang ,  Jong Hun Im ,  Jong In Kim ,  Ki Seok Kim ,  Sung Key Jang ,  II Ung Oh ,  Min Jeong Choi ,  Won Jun Kang

IPC分类号： C12N15/115 ,  G01N33/574

CPC分类号： C12N15/115 ,  A61K31/7088 ,  A61K47/60 ,  C12N2310/16 ,  C12N2310/335 ,  C12N2310/3535 ,  C12N2320/30 ,  G01N33/5748 ,  G01N2333/71 ,  G01N2333/91205

摘要： Disclosed are a DNA aptamer specifically binding to the Her2 (ERBB2) receptor involved in the onset of breast cancer, a composition for the suppression of cancer metastasis comprising the same as an active ingredient, and a composition for the diagnosis of cancer comprising the same as an active ingredient. Due to its binding mechanism being different from that of the conventional antibody, the aptamer can be effectively used for suppressing cancer metastasis and diagnosing cancer.

摘要翻译： 公开了特异性结合参与乳腺癌发病的Her2（ERBB2）受体的DNA适体，用于抑制与其相同的活性成分的癌症转移的组合物，以及用于诊断癌症的组合物，其包含与 活性成分。 由于其结合机理与常规抗体的结合机制不同，适体可以有效地用于抑制癌症转移和诊断癌症。