公开(公告)号：US20020123459A1

公开(公告)日：2002-09-05

申请号：US10006311

申请日：2001-12-04

Inventor： Joseph M. Ault ,  Moise Azria ,  Simon David Bateman ,  Joseph Sikora ,  Gregory Sparta ,  Rebecca Fai-ying Yang ,  Jie Xiao

IPC: A01N037/18 ,  A61K038/00 ,  C07K005/00 ,  C07K016/00 ,  C07K007/00 ,  C07K017/00 ,  A61K038/23

CPC classification number: A61K9/2027 ,  A61K9/2013 ,  A61K9/2054 ,  A61K47/183

Abstract: Solid pharmaceutical compositions suitable for the oral delivery of pharmacologically active agents, e.g. peptides, comprising a therapeutically-effective amount of a pharmacologically active agent; a crospovidone or povidone; and a delivery agent for said pharmacologically active agent are disclosed. The compositions provide excellent oral bioavailability of pharmacologically active agents, particularly calcitonin.

Abstract translation: 适用于口服递送药理学活性剂的固体药物组合物，例如 肽，包含治疗有效量的药理活性剂; 交聚维酮或聚维酮; 并公开了所述药理活性剂的递送剂。 该组合物提供药理活性剂，特别是降钙素的极好的口服生物利用度。

公开(公告)号：US20020123457A1

公开(公告)日：2002-09-05

申请号：US09381261

申请日：1999-12-07

Inventor： JOSEPH LOSCALZO ,  AIDA INBAL

IPC: A01N037/18 ,  A61K038/00 ,  C07K002/00 ,  C07K004/00 ,  C07K005/00 ,  C07K007/00 ,  C07K014/00 ,  C07K016/00 ,  C07K017/00

CPC classification number: C07K14/355 ,  A61K38/00

Abstract: This invention combines the unique antiplatelet effects of S-nitrosothiols and the antiadhesive properties of fragments of vWF in the A1 domain to provide unique molecules that exploit both of these properties. Preferred molecules comprise a fragment of A1 (ala444-asp73O) in which arginine at position 545 is replaced by cysteine (the most frequent von Willebrand disease type 2b mutation) that has been discovered to impair platelet adhesion, and to exhibit antithrombotic activity in vivo. This cysteine residue may be S-nitrosated to produce a novel molecule that has the potential for impairing platelet adhesion as well as activation/aggregation, and such molecules form the basis of a novel therapeutic method for impairing platelet responses following vascular injury or in other thrombotic disorders according to this invention.

Abstract translation: 本发明将S-亚硝基硫醇的独特抗血小板作用和vWF片段的抗粘附性质结合在A1结构域中，以提供利用这两种特性的独特分子。 优选的分子包含A1（ala444-asp73O）的片段，其中545处的精氨酸被已被发现损伤血小板粘附的半胱氨酸（最常见的血管性血友病血型B型突变）所代替，并在体内表现出抗血栓形成活性。 该半胱氨酸残基可以被S-亚硝基化以产生具有损害血小板粘附和活化/聚集的潜力的新分子，并且这些分子形成用于损伤血管损伤或其它血栓形成后血小板反应的新型治疗方法的基础 根据本发明的病症。

公开(公告)号：US20020123039A1

公开(公告)日：2002-09-05

申请号：US10000321

申请日：2001-12-04

Inventor： Stefan Brust ,  Stefan Knapp ,  Manfred Gerken ,  Lutz G. Guertler

IPC: C12Q001/70 ,  C12Q001/68 ,  C07H021/04 ,  C12P019/34 ,  A61K039/12 ,  A61K039/21 ,  C07K002/00 ,  C07K004/00 ,  C07K005/00 ,  C07K007/00 ,  C07K014/00 ,  C07K016/00 ,  C07K017/00 ,  A61K038/00

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/1045 ,  C07K2317/21 ,  C12N2740/16022 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12Q1/703

Abstract: Immunologically active peptides which are derived from a novel immunodeficiency virus which has the designation MVP5180/91 are described. A diagnostic composition containing such a peptide and methods of detecting an antibody against a retrovirus that causes immune deficiency using such diagnostic composition are also described. A kit containing the immunologically active peptides is also described. An immunogen and method of immunizing a mammal against HIV infection using the immunologically active peptides is described. DNA encoding the peptides and methods of detecting nucleic acids encoding HIV viruses are also described.

Abstract translation: 描述了衍生自具有名称MVP5180 / 91的新型免疫缺陷病毒的免疫活性肽。 还描述了含有这种肽的诊断组合物和使用这种诊断组合物检测引起免疫缺陷的逆转录病毒抗体的方法。 还描述了含有免疫活性肽的试剂盒。 描述了使用免疫活性肽免疫哺乳动物抗HIV感染的免疫原和方法。 还描述了编码肽的DNA和检测编码HIV病毒的核酸的方法。

公开(公告)号：US20020115830A1

公开(公告)日：2002-08-22

申请号：US10090378

申请日：2002-03-04

Inventor： Antonito T. Panganiban ,  Michael A. Callahan ,  Mark A. Handley

IPC: C12Q001/70 ,  C07H021/04 ,  A61K039/21 ,  C07K002/00 ,  C07K004/00 ,  C07K005/00 ,  C07K007/00 ,  C07K014/00 ,  C07K016/00 ,  C07K017/00 ,  A61K038/00 ,  C07K001/00 ,  G01N033/53

CPC classification number: C07K14/47 ,  C12Q1/703

Abstract: A preparation of U binding protein (Ubp) and a gene sequence encoding Ubp and an anti-Ubp antibody are disclosed. An assay to identify modulators of Ubp/Vpu interaction and Gag/Ubp interaction is also disclosed.

公开(公告)号：US20020111300A1

公开(公告)日：2002-08-15

申请号：US09200791

申请日：1998-11-30

Inventor： THOMAS M. BEHR ,  DAVID M. GOLDENBERG

IPC: A61K038/00 ,  A61K031/66 ,  A01N057/00 ,  C07K002/00 ,  C07K004/00 ,  C07K005/00 ,  C07K007/00 ,  C07K014/00 ,  C07K016/00 ,  C07K017/00 ,  C07K001/00

CPC classification number: B82Y5/00 ,  A61K31/198 ,  A61K38/16 ,  A61K39/395 ,  A61K47/6895 ,  A61K2300/00

Abstract: Kidney uptake of antibody fragment conjugates and protein conjugates in patients is reduced by administration to the patient of one or more compounds selected from the group consisting of D-lysine, poly-D-lysine, or poly-L-lysine, or pharmaceutically acceptable salts or carboxyl derivatives thereof.

Abstract translation: 通过向患者施用一种或多种选自D-赖氨酸，聚-D-赖氨酸或聚-L-赖氨酸的化合物或其药学上可接受的盐，减少患者中抗体片段缀合物和蛋白质缀合物的肾摄取 或其羧基衍生物。

公开(公告)号：US20020103344A1

公开(公告)日：2002-08-01

申请号：US09960653

申请日：2001-09-24

Inventor： Francisco Veas ,  Franz Jansen ,  Dorothee Misse

IPC: A61K039/12 ,  A61K039/21 ,  C07K002/00 ,  C07K004/00 ,  C07K005/00 ,  C07K007/00 ,  C07K014/00 ,  C07K016/00 ,  C07K017/00 ,  A61K038/00 ,  C12P021/08

CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N2740/16122

Abstract: The invention concerns retrovirus envelope glycoprotein mutants characterized in that they are glycoproteins capable of specifically binding with chemokine receptors and having an inhibiting activity with respect to a retroviral infection.

Abstract translation: 本发明涉及逆转录病毒包膜糖蛋白突变体，其特征在于它们是能够与趋化因子受体特异性结合并对逆转录病毒感染具有抑制活性的糖蛋白。

公开(公告)号：US20020102723A1

公开(公告)日：2002-08-01

申请号：US09870574

申请日：2001-05-30

Applicant: GENENTECH, INC.

Inventor： Austin L. Gurney ,  Sudeepta Aggarwal ,  Ming-Hong Xie ,  Ellen M. Maruoka ,  Jessica S. Foster ,  Audrey Goddard ,  William I. Wood

IPC: C07H021/04 ,  A61K031/70 ,  C12N015/63 ,  A01N043/04 ,  C12N015/74 ,  C12P021/06 ,  C12P021/04 ,  A61K039/395 ,  A61K039/40 ,  A61K039/42 ,  C12N015/00 ,  C12N015/09 ,  C12N015/70 ,  C07K005/00 ,  C07K007/00 ,  C07K016/00 ,  C07K017/00 ,  A61K038/00 ,  C12N005/00 ,  C12N005/02 ,  C07K001/00 ,  C07K014/00 ,  C12P021/08

CPC classification number: C07K14/54 ,  A61K38/00 ,  C07K2319/30 ,  G01N2333/54 ,  G01N2500/10

Abstract: The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract translation: 本发明涉及白细胞介素-22多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20020102607A1

公开(公告)日：2002-08-01

申请号：US09894882

申请日：2001-06-29

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Craig S. Walker ,  Reshma Shetty ,  Elsie C. Jimenez ,  J. Michael McIntosh ,  Baldomero M. Olivera ,  Maren Watkins ,  Robert M. Jones ,  Gregory S. Shen

IPC: A01N037/18 ,  A61K038/00 ,  G01N033/53 ,  A61K038/16 ,  C07K005/00 ,  C07K007/00 ,  C07K016/00 ,  C07K017/00 ,  C07K001/00 ,  C07K014/00

CPC classification number: C07K14/43504

Abstract: The invention relates to relatively short peptides (termed I-conotoxins herein), about 30-50 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include four disulfide bonds.

Abstract translation: 本发明涉及相对短的肽（本文中称为I-芋螺毒素），长度约30-50个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括四个 二硫键。

公开(公告)号：US20020102533A1

公开(公告)日：2002-08-01

申请号：US09878579

申请日：2001-06-11

Inventor： Charles A. Kettner ,  Mark S. Hixon

IPC: C12Q001/70 ,  C12N009/50 ,  G01N033/53 ,  C07K007/00 ,  C07K017/00 ,  C07K005/00 ,  C07K016/00 ,  A61K038/04

CPC classification number: C12N9/506 ,  C12Q1/37 ,  G01N33/5767 ,  G01N2500/04

Abstract: This invention relates to a novel method of hepatitis C protease inhibition through interaction with a novel exosite remote from the active site but overlapping with P4null-P6null region of the extended substrate binding site. In particular, the present invention provides a description of a region of the enzyme and structure activity relationships of peptides with affinity for this exosite. Ligands binding in the exosite are competitive with larger substrates such as the physiological substrate. As such, exploitation of the exosite represents a therapeutic for the hepatitis C disease.

Abstract translation: 本发明涉及通过与远离活性位点但与扩展的底物结合位点的P4'-P6'区重叠的新型外显子相互作用的丙型肝炎蛋白酶抑制的新方法。 特别地，本发明提供酶的区域和对该外部位点的亲和力的肽的结构活性关系的描述。 在外部位点结合的配体与较大的底物如生理底物竞争。 因此，外部位点的开发代表了丙型肝炎疾病的治疗剂。

公开(公告)号：US20020091086A1

公开(公告)日：2002-07-11

申请号：US09827822

申请日：2001-04-06

Inventor： Anders Vahlne

IPC: A01N037/18 ,  C12Q001/70 ,  C12N007/01 ,  C07K004/00 ,  C07K007/00 ,  C07K016/00 ,  A61K038/06 ,  A61K038/00 ,  C12N007/00 ,  C07K002/00 ,  C07K005/00 ,  C07K014/00 ,  C07K017/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N2740/15022 ,  C12N2740/16122 ,  Y10S977/916

Abstract: The discovery of peptides in amide form that inhibit viral infection, including human immunodeficiency virus (HIV) infection is disclosed. Methods of use of peptides are also disclosed including use in medicaments for the treatment and prevention of viral infection, such as HIV infection.

Abstract translation: 公开了发现抑制病毒感染的酰胺形式的肽，包括人类免疫缺陷病毒（HIV）感染。 还公开了使用肽的方法，包括在药物中的用途，用于治疗和预防病毒感染，例如HIV感染。