公开(公告)号：US20030109670A1

公开(公告)日：2003-06-12

申请号：US10072602

申请日：2002-02-11

Applicant: University of Utah Research Foundation

Inventor： Baldomero M. Olivera ,  J. Michael McIntosh ,  Maren Watkins ,  James E. Garrett ,  Lourdes J. Cruz ,  Michelle Grilley ,  Robert A. Schoenfeld ,  Craig S. Walker ,  Reshma P. Shetty ,  Robert M. Jones

IPC: A61K038/00 ,  C07K005/00 ,  C07K016/00 ,  C07K007/00 ,  C07K017/00 ,  C07H021/04 ,  C12N001/20 ,  C12N015/00 ,  C12N015/09 ,  C12N015/63 ,  C12N015/70 ,  C12N015/74 ,  C12N005/00 ,  C12N005/02

CPC classification number: C07K14/43504 ,  A61K38/00

Abstract: The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.

Abstract translation: 本发明涉及芋螺毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，电压门控配体通道和/或受体相关的病症中的用途。 本发明还涉及编码芋螺毒素肽和编码前肽以及前肽的核酸序列。

公开(公告)号：US20030065138A1

公开(公告)日：2003-04-03

申请号：US10092367

申请日：2002-03-07

Applicant: University of Utah Research Foundation

Inventor： Baldomero M. Olivera ,  J. Michael McIntosh ,  James E. Garrett ,  Craig S. Walker ,  Maren Watkins ,  Robert M. Jones

IPC: C07K007/08 ,  C07K014/435

CPC classification number: C07K14/43504 ,  A61K38/00

Abstract: The invention relates to linear null-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.

Abstract translation: 本发明涉及线性γ-羧基谷氨酸富含芋螺毒素，其衍生物或其药学上可接受的盐及其用途，包括治疗神经系统疾病和精神病学疾病，如抗惊厥剂，神经保护剂或用于治疗疼痛。 本发明还涉及编码肽和编码前肽以及前肽的核酸序列。

公开(公告)号：US20020102607A1

公开(公告)日：2002-08-01

申请号：US09894882

申请日：2001-06-29

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Craig S. Walker ,  Reshma Shetty ,  Elsie C. Jimenez ,  J. Michael McIntosh ,  Baldomero M. Olivera ,  Maren Watkins ,  Robert M. Jones ,  Gregory S. Shen

IPC: A01N037/18 ,  A61K038/00 ,  G01N033/53 ,  A61K038/16 ,  C07K005/00 ,  C07K007/00 ,  C07K016/00 ,  C07K017/00 ,  C07K001/00 ,  C07K014/00

CPC classification number: C07K14/43504

Abstract: The invention relates to relatively short peptides (termed I-conotoxins herein), about 30-50 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include four disulfide bonds.

Abstract translation: 本发明涉及相对短的肽（本文中称为I-芋螺毒素），长度约30-50个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括四个 二硫键。