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公开(公告)号：US20030050234A1
公开(公告)日：2003-03-13
申请号：US09910009
申请日：2001-07-23
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Baldomero M. Olivera , J. Michael McIntosh , James E. Garrett , Maren Watkins , Lourdes J. Cruz , Ki-Joon Shon , Richard B. Jacobsen , Robert M. Jones , G. Edward Cartier , Gregory S. Shen , John D. Wagstaff
IPC: A61K038/17 , C07K014/435
CPC classification number: C07K14/43504 , A61K38/00
Abstract: The present invention is to null-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the null-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The null-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the null-conopeptides and encoding propeptides, as well as the propeptides.
Abstract translation: 本发明涉及多肽，其衍生物或药学上可接受的盐。 本发明还涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控钠通道相关的疾病中的用途。 因此，μ-肽或衍生物可用作神经肌肉阻滞剂，局部麻醉剂，止痛剂和神经保护剂。 多肽也可用于治疗神经肌肉疾病。 本发明还涉及编码多肽的核酸序列和编码前肽以及前肽。
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公开(公告)号：US20040204362A1
公开(公告)日：2004-10-14
申请号：US10839179
申请日：2004-05-06
Applicant: The University of Utah Research Foundation , Cognetix, Inc.
Inventor： Baldomero M. Olivera , Richard T. Layer , Maren Watkins , David R. Hillyard , J. Michael McIntosh , Robert Schoenfeld , Jacob Scott Nielsen , Robert M. Jones
IPC: A61K038/17 , C07K014/435 , C07H021/04
CPC classification number: C07K14/435 , A61K38/00 , C07K14/43504
Abstract: The invention relates to relatively short peptides (termed null-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The null-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.
Abstract translation: 本发明涉及相对短的肽（本文中称为α-芋螺毒素），长度约10-25个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。 如本文所述，α-蛇毒毒素可用作神经肌肉阻滞剂，例如肌肉松弛剂。
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公开(公告)号：US20040192886A1
公开(公告)日：2004-09-30
申请号：US10828478
申请日：2004-04-21
Applicant: The University of Utah Research Foundation , Cognetix, Inc.
Inventor： Baldomero M. Olivera , J. Michael McIntosh , James E. Garrett , Maren Watkins , Lourdes J. Cruz , Ki-Joon Shon , Richard B. Jacobsen , Robert M. Jones , G. Edward Cartier , Gregory S. Shen , John D. Wagstaff
IPC: A61K038/17 , C07K014/47
CPC classification number: C07K14/43504 , A61K38/00
Abstract: The present invention is to null-conopeptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the null-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The null-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the null-conopeptides and encoding propeptides, as well as the propeptides.
Abstract translation: 本发明涉及多肽，其衍生物或药学上可接受的盐。 本发明还涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控钠通道相关的疾病中的用途。 因此，μ-肽或衍生物可用作神经肌肉阻滞剂，局部麻醉剂，止痛剂和神经保护剂。 多肽也可用于治疗神经肌肉疾病。 本发明还涉及编码多肽的核酸序列和编码前肽以及前肽。
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公开(公告)号：US20040176278A1
公开(公告)日：2004-09-09
申请号：US10838226
申请日：2004-05-05
Applicant: University of Utah Research Foundation , Cognetix, Inc.
Inventor： Robert M. Jones , Baldomero M. Olivera , Maren Watkins , James E. Garrett
IPC: C07K014/435 , A61K038/17
CPC classification number: C07K14/43504
Abstract: The present invention is directed to null-superfamily conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, ligand gated channels and other receptors. The invention is further directed to nucleic acid sequences encoding the null-superfamily conotoxin peptides and encoding null-superfamily conotoxin propeptides, as well as the null-superfamily conotoxin propeptides.
Abstract translation: 本发明涉及β-超家族荚果毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，配体门控通道和其它受体相关的病症中的用途。 本发明还涉及编码β-超家族荚果毒素肽和编码β-超家族荚果毒素前肽以及β-超家族荚果毒素前肽的核酸序列。
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公开(公告)号：US20040132663A1
公开(公告)日：2004-07-08
申请号：US10765926
申请日：2004-01-29
Applicant: University of Utah Research Foundation , Cognetix, Inc.
Inventor： Baldomero M. Olivera , J. Michael McIntosh , Maren Watkins , James E. Garrett , Ki-Joon Shon , Richard B. Jacobsen , Robert M. Jones , G. Edward Cartier
IPC: A61K038/17 , C07K014/435 , C12Q001/68 , C07H021/04
CPC classification number: C07K14/43504 , A61K38/00
Abstract: The invention relates to null-conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents, as cardiovascular agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
Abstract translation: 本发明涉及ω-肽，其衍生物或其药学上可接受的盐及其用途，包括治疗神经和精神疾病，如抗惊厥剂，神经保护剂，心血管药物或用于治疗疼痛。 本发明还涉及编码肽和编码前肽以及前肽的核酸序列。
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Patent Agency Ranking
公开(公告)号：US20030119731A1
公开(公告)日：2003-06-26
申请号：US09910082
申请日：2001-07-23
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Baldomero M. Olivera , J. Michael McIntosh , Maren Watkins , James E. Garrett , Ki-Joon Shon , Richard B. Jacobsen , Robert M. Jones , G. Edward Cartier
IPC: A61K038/17 , C07K014/435 , C07H021/04
CPC classification number: C07K14/43504 , A61K38/00
Abstract: The invention relates to null-conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents, as cardiovascular agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
Abstract translation: 本发明涉及ω-肽，其衍生物或其药学上可接受的盐及其用途，包括治疗神经和精神疾病，如抗惊厥剂，神经保护剂，心血管药物或用于治疗疼痛。 本发明还涉及编码肽和编码前肽以及前肽的核酸序列。
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公开(公告)号：US20030170222A1
公开(公告)日：2003-09-11
申请号：US10058053
申请日：2002-01-29
Applicant: University of Utah Research Foundation
Inventor： Robert M. Jones , Baldomero M. Olivera , Maren Watkins , James E. Garrett
IPC: A61K038/17 , A61K038/43 , C07K014/435
CPC classification number: C07K14/43504
Abstract: The present invention is directed to null-superfamily conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, ligand gated channels and other receptors. The invention is further directed to nucleic acid sequences encoding the null-superfamily conotoxin peptides and encoding null-superfamily conotoxin propeptides, as well as the null-superfamily conotoxin propeptides.
Abstract translation: 本发明涉及β-超家族荚果毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，配体门控通道和其它受体相关的病症中的用途。 本发明还涉及编码β-超家族荚果毒素肽和编码β-超家族荚果毒素前肽以及β-超家族荚果毒素前肽的核酸序列。
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公开(公告)号：US20030109670A1
公开(公告)日：2003-06-12
申请号：US10072602
申请日：2002-02-11
Applicant: University of Utah Research Foundation
Inventor： Baldomero M. Olivera , J. Michael McIntosh , Maren Watkins , James E. Garrett , Lourdes J. Cruz , Michelle Grilley , Robert A. Schoenfeld , Craig S. Walker , Reshma P. Shetty , Robert M. Jones
IPC: A61K038/00 , C07K005/00 , C07K016/00 , C07K007/00 , C07K017/00 , C07H021/04 , C12N001/20 , C12N015/00 , C12N015/09 , C12N015/63 , C12N015/70 , C12N015/74 , C12N005/00 , C12N005/02
CPC classification number: C07K14/43504 , A61K38/00
Abstract: The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.
Abstract translation: 本发明涉及芋螺毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，电压门控配体通道和/或受体相关的病症中的用途。 本发明还涉及编码芋螺毒素肽和编码前肽以及前肽的核酸序列。
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公开(公告)号：US20030065138A1
公开(公告)日：2003-04-03
申请号：US10092367
申请日：2002-03-07
Applicant: University of Utah Research Foundation
Inventor： Baldomero M. Olivera , J. Michael McIntosh , James E. Garrett , Craig S. Walker , Maren Watkins , Robert M. Jones
IPC: C07K007/08 , C07K014/435
CPC classification number: C07K14/43504 , A61K38/00
Abstract: The invention relates to linear null-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
Abstract translation: 本发明涉及线性γ-羧基谷氨酸富含芋螺毒素，其衍生物或其药学上可接受的盐及其用途，包括治疗神经系统疾病和精神病学疾病，如抗惊厥剂，神经保护剂或用于治疗疼痛。 本发明还涉及编码肽和编码前肽以及前肽的核酸序列。
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公开(公告)号：US20030050435A1
公开(公告)日：2003-03-13
申请号：US09908741
申请日：2001-07-20
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Baldomero M. Olivera , Richard T. Layer , Maren Watkins , David R. Hillyard , J. Michael McIntosh , Robert Schoenfeld , Jacob Scott Nielsen , Robert M. Jones
IPC: A61K038/17 , C07K014/435 , C07H021/04
CPC classification number: C07K14/43504 , A61K38/00
Abstract: The invention relates to relatively short peptides (termed null-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The null-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.
Abstract translation: 本发明涉及相对短的肽（本文中称为α-芋螺毒素），长度约10-25个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且其优选包括两个 二硫键。 如本文所述，α-蛇毒毒素可用作神经肌肉阻滞剂，例如肌肉松弛剂。
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