公开(公告)号：US10071364B2

公开(公告)日：2018-09-11

申请号：US14598401

申请日：2015-01-16

Applicant: Genzyme Corporation

Inventor： Rahul Godawat ,  Veena Warikoo ,  Rohan Patil ,  Konstantin Konstantinov ,  Venkat Kishore Ryakala

IPC: A61L2/08 ,  B01J20/34 ,  B01D15/36 ,  B01D15/38 ,  B01J20/26 ,  B01J20/281 ,  B01J41/12 ,  B01J41/20 ,  C07K1/16 ,  C07K1/22 ,  C07K1/18 ,  B01D15/18 ,  B01D15/20 ,  B01D15/32 ,  B01D15/34 ,  B01J39/26

CPC classification number: B01J20/3441 ,  A61L2/081 ,  B01D15/1864 ,  B01D15/20 ,  B01D15/327 ,  B01D15/34 ,  B01D15/362 ,  B01D15/363 ,  B01D15/3804 ,  B01J20/265 ,  B01J20/281 ,  B01J39/26 ,  B01J41/12 ,  B01J41/20 ,  C07K1/16 ,  C07K1/18 ,  C07K1/22 ,  Y10T29/49826

Abstract: Provided herein are methods of reducing bioburden of (e.g., sterilizing) a chromatography resin that include exposing a container including a composition including a chromatography resin and at least one antioxidant agent and/or chelator to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one antioxidant agent and/or chelator are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and at least one chelator and/or antioxidant agent, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein.

公开(公告)号：US20180252687A1

公开(公告)日：2018-09-06

申请号：US15971150

申请日：2018-05-04

Applicant: Tecan SP, Inc.

Inventor： Philip A. Dimson

IPC: G01N30/60 ,  B01D15/22 ,  G01N33/487 ,  B01D15/20 ,  G01N1/10 ,  G01N1/40

CPC classification number: G01N30/6065 ,  B01D15/206 ,  B01D15/22 ,  G01N1/10 ,  G01N1/405 ,  G01N30/6039 ,  G01N30/6069 ,  G01N30/6095 ,  G01N33/487 ,  G01N2001/4061

Abstract: An apparatus for extracting an analyte from a liquid sample having a container with an entrance, an exit, and a passage therebetween for passage of a liquid sample containing an analyte, the container having a full diameter bed region and a reduced diameter bed region. The container includes a layered construction extending across the passage, having from top to bottom one or more of: (i) an upper flow distributor/support layer, (ii) an upper compression layer, (iii) an extraction layer of microparticulate extraction medium adjacent to the layer (ii), and (iv) a lower compression layer located adjacent to the extraction layer (iii), optionally including one or more air gap layers. At least some of the layers are located in the full diameter bed region, and some of the layers are located in the reduced diameter bed region. The apparatus may have a plurality of containers arranged in an array and/or in series so as to provide multi-stage filtration or extraction.

公开(公告)号：US10052566B2

公开(公告)日：2018-08-21

申请号：US14759029

申请日：2014-12-02

Applicant: MERCK PATENT GMBH

Inventor： Guenter Hauke ,  Sebastien Marie ,  Leticia Garcia Diez ,  Michael Ukelis ,  Andreas Beirau ,  Michael Haeberl

IPC: B01D15/22 ,  B01D15/14 ,  B01D15/08 ,  B01D15/20 ,  C09K19/34 ,  C09K19/54 ,  C09K19/04 ,  C09K19/30

CPC classification number: B01D15/22 ,  B01D15/08 ,  B01D15/14 ,  B01D15/206 ,  B01D2201/302 ,  B01D2201/304 ,  B01D2201/347 ,  C09K19/3003 ,  C09K19/3066 ,  C09K19/3402 ,  C09K19/542 ,  C09K2019/0448 ,  C09K2019/0466 ,  C09K2019/3004 ,  C09K2019/3009 ,  C09K2019/301 ,  C09K2019/3016 ,  C09K2019/3027 ,  C09K2019/3422 ,  C09K2019/548 ,  C09K2219/00

Abstract: A purification device (1), for the purification of a liquid-crystal mixture, has a flow chamber (2) which has an inlet opening (3) and an outlet opening (4), arranged opposite the inlet opening, in order to be able to introduce the liquid-crystal mixture into the flow chamber (2) and discharge it from the latter, and at least one flow distribution element (5) which is arranged in the flow chamber (2) in the region of the inlet opening (3), and at least one filter element (6) which is arranged in the region of the outlet opening (4), where a length of the flow chamber (2) measured in the flow direction is at least a factor of 2 greater than a greatest internal dimension of the flow chamber (2) transverse to the flow direction.

公开(公告)号：US20180229212A1

公开(公告)日：2018-08-16

申请号：US15874211

申请日：2018-01-18

Applicant: WON Hi Tech Corp.

Inventor： Min BAEK ,  Ji Woong CHOI

IPC: B01J20/04 ,  B01D15/20 ,  C01D15/00

CPC classification number: B01J20/04 ,  B01D15/20 ,  B01D2253/112 ,  B01D2253/308 ,  B01D2256/12 ,  B01D2257/102 ,  C01D15/00

Abstract: The present disclosure provides an adsorption tower for an oxygen generator system configured to adsorb nitrogen in air and supply oxygen, the tower comprising: a housing defining an inner space therein in which an adsorbing agent is filled; a housing inlet through which air enters into the housing; an housing outlet through which air is discharged from the housing, wherein the housing inlet is opposite to the housing outlet; a sodium based adsorbing agent layer disposed in the inner space and adjacent to the housing inlet; and a lithium-based adsorbing agent layer disposed in the inner space and adjacent the housing outlet.

公开(公告)号：US20180154280A1

公开(公告)日：2018-06-07

申请号：US15890144

申请日：2018-02-06

Applicant: Repligen Corporation

Inventor： James Ronald Peyser ,  Dana Cristina Pentia

IPC: B01D15/20 ,  A61L2/08 ,  B01D15/32 ,  B01D15/36 ,  B01D15/38

Abstract: If one sterilizes pre-packed, plastic chromatography columns with an appropriate level of gamma irradiation, the resulting sterile chromatography columns maintain sufficient packing media function and maintain column mechanical properties and pressure ratings.

公开(公告)号：US09981861B2

公开(公告)日：2018-05-29

申请号：US15790880

申请日：2017-10-23

Applicant: Polymer Ventures Inc.

Inventor： Jonathan Fabri ,  David Beyer

IPC: B01J20/22 ,  B01D15/04 ,  C02F1/28 ,  B01D17/02 ,  B01J20/32 ,  B01J20/34 ,  B01D15/20 ,  C02F101/32

CPC classification number: C02F1/286 ,  B01D15/00 ,  B01D15/20 ,  B01D17/02 ,  B01D17/0202 ,  B01J20/3206 ,  B01J20/3248 ,  B01J20/3425 ,  B01J20/3475 ,  B01J2220/485 ,  C02F2101/006 ,  C02F2101/20 ,  C02F2101/306 ,  C02F2101/308 ,  C02F2101/32 ,  C02F2101/325 ,  C02F2103/008 ,  C02F2303/16

Abstract: Herein are described compositions useful in the purification of hydrocarbon-contaminated liquids (e.g., oil-contaminated water), methods of their manufacture, and methods of their use. In one instance, the composition can include a porous agricultural substrate selected from the group consisting of walnut shell, pecan shell, apricot pit, peach pit, corn cob, and a mixture thereof; the porous agricultural substrate having an external surface and pores, wherein the external surface is hydrophilic; and an organo-amine carried within the pores of the porous agricultural substrate. These compositions are utilized as regenerable filter media in place of, for example, ground walnut media.

公开(公告)号：US09958421B2

公开(公告)日：2018-05-01

申请号：US13518029

申请日：2010-12-20

Applicant: Klaus Gebauer ,  Elisabeth Hallgren ,  Raf Lemmens ,  Ola Lind ,  Bjorn Lundgren ,  Jamil Shanagar ,  Kajsa Stridsberg-Friden ,  Helena Widegren

Inventor： Klaus Gebauer ,  Elisabeth Hallgren ,  Raf Lemmens ,  Ola Lind ,  Bjorn Lundgren ,  Jamil Shanagar ,  Kajsa Stridsberg-Friden ,  Helena Widegren

IPC: G01N30/56 ,  B01D15/20 ,  G01N30/28 ,  B01J20/28 ,  B01D15/32 ,  B01J20/22 ,  B01D15/36 ,  B01J20/281 ,  B01J20/30 ,  B01D15/38 ,  B01J20/285

CPC classification number: G01N30/56 ,  B01D15/206 ,  B01D15/32 ,  B01D15/361 ,  B01D15/3804 ,  B01J20/22 ,  B01J20/28 ,  B01J20/28011 ,  B01J20/28016 ,  B01J20/285 ,  B01J20/3092 ,  G01N30/28 ,  G01N30/482

Abstract: The invention provides a packing method for high efficiency chromatography columns starting from dry swellable particles, as well as columns packed by the method and the use of the columns in separation of biomolecules. In the packing method, an amount of dry swellable particles sufficient to give a swollen volume in a liquid of about 105-120% of the column chamber volume is transferred to the column, the column is closed and the liquid is provided to the column.

公开(公告)号：US20180093202A1

公开(公告)日：2018-04-05

申请号：US15564888

申请日：2016-04-08

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： Alex Conradie

IPC: B01D15/36 ,  B01D15/20 ,  B01D15/18 ,  C07C227/40 ,  C07C229/06 ,  C07C51/47 ,  C07C53/126

CPC classification number: B01D15/362 ,  B01D15/1892 ,  B01D15/20 ,  B01D15/361 ,  C07C51/47 ,  C07C53/126 ,  C07C67/58 ,  C07C227/40 ,  C07C229/06

Abstract: This document describes a process for the high purity and high concentration recovery of monovalent products via continuous ion exchange from aqueous solution for further downstream purification.

公开(公告)号：US20180078876A1

公开(公告)日：2018-03-22

申请号：US15558033

申请日：2016-03-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jue Wang ,  Neil E. Jaffe ,  Krina Patel

IPC: B01D15/20 ,  B01D15/38 ,  B01D15/42 ,  B01D15/18 ,  C07K1/22 ,  C07K16/00

Abstract: In certain embodiments, the invention provides a method of purifying a protein of interest from a mixture which comprises the protein of interest and one or more contaminants, said method comprising: a) subjecting the mixture to a first chromatography matrix, wherein the protein of interest binds to the first chromatography matrix; b) contacting the first chromatography matrix with a first wash solution which has a pH of at least 9.0, and does not comprise arginine or an arginine derivative; and c) eluting the protein of interest from the first chromatography matrix into an elution solution.

公开(公告)号：US09897578B2

公开(公告)日：2018-02-20

申请号：US14428944

申请日：2013-09-19

Applicant: THERMO ELECTRON MANUFACTURING LIMITED

Inventor： Harald Ritchie

IPC: G01N30/60 ,  B01D15/20 ,  G01N30/52 ,  B01J20/28 ,  B01J20/283 ,  B01J20/10

CPC classification number: G01N30/60 ,  B01D15/20 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28052 ,  B01J20/28057 ,  B01J20/283 ,  B01J2220/58 ,  G01N30/52 ,  G01N30/6039 ,  G01N30/6069 ,  G01N2030/524

Abstract: A chromatography column (2) containing a bed of packed particles (22, 24, 26, 28, 30), wherein the packed particles comprise fused core particles and the particle diameters of the packed particles vary along the column. Preferably, the particles (2, 24, 26, 28, 30) are arranged according to their average particle diameter, in order of increasing average particle diameter from the inlet end (4) to the outlet end (6). The bed may comprise a plurality of bed sections and each bed section has an average particle diameter calculated from the particles in that section and there are at least two different average particle diameter bed sections, wherein the particles of each bed are separated from particles of an adjacent bed by a partition that is liquid permeable to allow through a flow of mobile phase. A high column efficiency can be provided with lower pressure drop per unit length of the column.