公开(公告)号：US20180272038A1

公开(公告)日：2018-09-27

申请号：US15993020

申请日：2018-05-30

Applicant: Association for the Advancement of Tissue Engineering and Cell Based Technologies & Therapie

Inventor： Albino Manuel Pereira Martins ,  Marta Luísa Sousa Dias Alves Da Silva ,  Rui Luís Gonçalves Dos Reis ,  Nuno João Meleiro Alves Das Neves

IPC: A61L27/58 ,  A61L27/60 ,  A61L15/20 ,  A61L27/56 ,  A61L27/54 ,  A61L15/64 ,  A61L27/26 ,  A61L27/20 ,  A61L15/26 ,  A61L15/28 ,  A61L15/22 ,  A61L27/18

CPC classification number: A61L27/58 ,  A61L15/20 ,  A61L15/225 ,  A61L15/26 ,  A61L15/28 ,  A61L15/64 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/54 ,  A61L27/56 ,  A61L27/60 ,  A61L2300/406 ,  A61L2430/06 ,  A61L2430/10 ,  A61L2430/12 ,  A61L2430/22

Abstract: The present application describes a polymeric mesh for the repair and regeneration of tissues from an organism that comprises pores wherein at least 70% of the pores of the said mesh have a size smaller than the one required to confine the cells of the said tissues, and wherein at least 70% of the pores of the said mesh has a size superior than the one needed for the passage of interstitial fluids of the said tissues; the degradation time of the said polymeric mesh within the organism is at least 8 weeks; the said polymeric mesh has an apparent tensile strength superior than 1 MPa; the said polymeric mesh has an apparent elastic modulus superior than 0.1 MPa. The mesh described in this application allows that the “new tissue” formed presents very similar properties to the ones of the damaged tissue.Thus, the polymeric mesh for the repair and regeneration of tissues described in this application can be used in medicine in combination or not with surgical methods, namely in the treatment of diseases that involve the repair and regeneration of tissues, particularly when the tissue to treat is cartilage, periodontal ligament, esophagus or skin.

公开(公告)号：US20180235893A1

公开(公告)日：2018-08-23

申请号：US15960654

申请日：2018-04-24

Applicant: The Procter & Gamble Company

Inventor： Hanwei ZHANG ,  Todd Arlin SCHWANTES ,  Katie Ann HOBART ,  Diane Jean WILLIAMSON

IPC: A61K9/50 ,  A01N25/28 ,  A61L15/46 ,  A61L15/60 ,  A61L15/22 ,  A61K8/11 ,  A61K8/81 ,  A61K8/87 ,  A61Q19/10 ,  A61Q5/02 ,  A61Q15/00 ,  C11D17/00 ,  C11D3/50 ,  B01J13/16 ,  F28D20/02

CPC classification number: A61K9/5031 ,  A01N25/28 ,  A61K8/11 ,  A61K8/8152 ,  A61K8/87 ,  A61K8/88 ,  A61K9/50 ,  A61K9/5026 ,  A61K9/5089 ,  A61K2800/412 ,  A61L15/225 ,  A61L15/46 ,  A61L15/60 ,  A61Q5/02 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/10 ,  B01J13/14 ,  B01J13/16 ,  B01J13/18 ,  C09B67/0097 ,  C10M171/06 ,  C10N2220/08 ,  C10N2250/16 ,  C11D3/505 ,  C11D17/0039 ,  F28D20/023

Abstract: An improved process of making a benefit agent delivery particle and consumer products incorporating such particles are disclosed. The process comprises the steps of providing a first composition of water phase 1, water phase 2 and water phase 3. Water phase 1 comprises water and an initiator; water phase 2 comprises water, a water-soluble or dispersible amine(meth)acrylate or hydroxyl(meth)acrylate and a multifunctional (meth)acrylate. Water phase 3 comprises water, and carboxyalkyl(meth)acrylate and a base or quarternary ammonium acrylate. The first two water phases are combined to prereact the hydroxy- or amine(meth)acrylate and the multifunctional (meth)acrylate to form a multifunctional hydroxyl-amine(meth)acrylate pre-polymer. The pre-polymer is combined with water phase 3; then an emulsion is formed by emulsifying under high shear agitation a second composition into said first composition; said second composition comprising an oil phase comprising an isocyanate and a benefit agent core material thereby forming a wall surrounding the benefit agent core material.

公开(公告)号：US09962458B2

公开(公告)日：2018-05-08

申请号：US14820915

申请日：2015-08-07

Applicant: LINKS MEDICAL PRODUCTS INCORPORATED

Inventor： Howard Kenneth Payne ,  Gregory Frank Devenish

IPC: A61F13/15 ,  A61L15/40 ,  A61F13/02 ,  A61L15/60 ,  A61L15/44 ,  A61L15/46 ,  A61L15/22 ,  A61L15/58 ,  B32B5/02 ,  B32B5/18 ,  B32B7/12 ,  B32B37/02 ,  B32B37/06 ,  B32B37/14 ,  B32B37/20 ,  B32B38/00 ,  B32B38/08 ,  A61L15/24 ,  A61L15/26 ,  A61L15/42 ,  A61F13/00

CPC classification number: A61L15/40 ,  A61F13/00063 ,  A61F13/0209 ,  A61F13/0223 ,  A61F13/0253 ,  A61F13/0289 ,  A61F2013/00314 ,  A61F2013/00331 ,  A61L15/225 ,  A61L15/24 ,  A61L15/26 ,  A61L15/425 ,  A61L15/44 ,  A61L15/46 ,  A61L15/58 ,  A61L15/60 ,  A61L2300/404 ,  A61L2300/41 ,  B32B5/02 ,  B32B5/022 ,  B32B5/18 ,  B32B7/12 ,  B32B37/02 ,  B32B37/06 ,  B32B37/144 ,  B32B37/203 ,  B32B38/0004 ,  B32B38/08 ,  B32B2255/02 ,  B32B2260/021 ,  B32B2260/04 ,  B32B2262/0292 ,  B32B2307/726 ,  B32B2371/00 ,  B32B2375/00 ,  B32B2535/00 ,  B32B2555/02 ,  Y10T156/1052 ,  C08L23/06 ,  C08L75/04

Abstract: A super absorbent, honey-dosed foam/fiber composite, gap patterned wound dressing, comprising: a patterned foam/fiber composite structure having a gap patterned side and a non-gap patterned side, wherein the patterned side includes a pattern of foam/fiber gaps disposed between foam/fiber areas dosed with honey, where the pattern of foam/fiber gaps is formed by the honey-dosed areas, such that the patterned foam/fiber composite structure includes a layer of super absorbent material located substantially adjacent to the honey-dosed areas; and wherein a wound in contact with the gap patterned side discharges an exudate which substantially collects in the individual ones of the foam/fiber gaps causing honey in the individual ones of the honey-dosed areas to be substantially dispersed throughout a wound treatment zone and a portion of the exudate that is collected in the individual ones of the foam/fiber gaps is transferred to and collected in the super absorbent material.

公开(公告)号：US20180117210A1

公开(公告)日：2018-05-03

申请号：US15605660

申请日：2017-05-25

Applicant: STB, LTD.

Inventor： MARTIN MACPHEE ,  DAWSON BEALL ,  DANIEL GRAHAM ,  ROB MARTEL ,  ANGELA MITCHEL ,  CHRISTINE HAEFLING ,  PETER BROWN ,  RICH DEGERONIMO ,  JERRY KANELLOS ,  BELINDA WILMER ,  SHIRLEY MIEKKA

IPC: A61L15/64 ,  A61F13/02 ,  A61L15/44 ,  A61K38/36 ,  A61K38/48 ,  A61L15/58 ,  A61L15/38 ,  A61L15/26 ,  A61F13/00 ,  A61L15/18 ,  A61L15/28 ,  A61L15/32 ,  A61L26/00 ,  A61L15/22 ,  C08L89/00

CPC classification number: A61L15/64 ,  A61F13/00012 ,  A61F13/00017 ,  A61F13/00021 ,  A61F13/00029 ,  A61F13/00034 ,  A61F13/00063 ,  A61F13/00068 ,  A61F13/00991 ,  A61F13/02 ,  A61F13/0226 ,  A61F13/0246 ,  A61F2013/00106 ,  A61F2013/00174 ,  A61F2013/00463 ,  A61F2013/00472 ,  A61F2013/00536 ,  A61F2013/0054 ,  A61F2013/0091 ,  A61F2013/00931 ,  A61K38/363 ,  A61K38/4833 ,  A61L15/18 ,  A61L15/225 ,  A61L15/26 ,  A61L15/28 ,  A61L15/32 ,  A61L15/325 ,  A61L15/38 ,  A61L15/44 ,  A61L15/58 ,  A61L26/0042 ,  A61L26/0052 ,  A61L26/0066 ,  A61L26/009 ,  A61L2300/10 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/418 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2400/04 ,  C08L89/00 ,  C12Y304/21005 ,  C08L5/08

Abstract: Disclosed are solid dressings for treating wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of a fibrinogen component and a fibrinogen activator, wherein the haemostatic layer(s) is cast or formed from a single aqueous solution containing the fibrinogen component and the fibrinogen activator. Also disclosed are methods for treating wounded tissue using these dressings and frozen compositions useful for preparing the haemostatic layer(s) of these dressings.

公开(公告)号：US20180104377A1

公开(公告)日：2018-04-19

申请号：US15843338

申请日：2017-12-15

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

Inventor： Hans Christian Hedrich ,  Joris Hoefinghoff ,  Woonza M. Rhee ,  Atsushi Edward Osawa

IPC: A61L15/42 ,  A61F13/02 ,  A61L15/58 ,  A61L15/22 ,  C08G65/334 ,  C09J171/02 ,  A61F13/15 ,  A61F13/00

CPC classification number: A61L15/425 ,  A61F13/00012 ,  A61F13/0213 ,  A61F13/025 ,  A61F13/0253 ,  A61F13/0289 ,  A61F13/15577 ,  A61F2013/00463 ,  A61F2013/00468 ,  A61F2013/00472 ,  A61L15/225 ,  A61L15/58 ,  A61L2400/04 ,  C08G65/334 ,  C08L71/02 ,  C08L2205/05 ,  C09J171/02

Abstract: The present invention provides a hemostatic composite sponge comprising oxidized cellulose and an essentially gelatin-free bioadhesive material stably associated with said sponge and present in an organized pattern on said sponge.

公开(公告)号：US20180042980A1

公开(公告)日：2018-02-15

申请号：US15384383

申请日：2016-12-20

Applicant: DATT MEDIPRODUCTS LIMITED ,  DATT LIFE SCIENCE PVT. LTD.

Inventor： Rajan Datt ,  RAMADHAR KUMAR ,  SIDDHARTH PANDEY ,  PALLAVI SHRIVASTAVA

IPC: A61K36/9066 ,  A61K36/82 ,  A61L15/44 ,  A61L15/40 ,  A61L15/22 ,  A61L15/42 ,  A61L15/20 ,  A61K47/10 ,  A61K47/22 ,  A61K47/34 ,  A61K9/70 ,  A61L15/18 ,  A61K33/38 ,  A61K36/886 ,  A61K47/32 ,  A61K47/36 ,  A61L15/58 ,  A61K31/765 ,  A61K36/185

CPC classification number: A61K36/9066 ,  A61F13/00012 ,  A61F13/00017 ,  A61F2013/00638 ,  A61F2013/00646 ,  A61F2013/0091 ,  A61K9/7069 ,  A61K31/765 ,  A61K33/38 ,  A61K36/185 ,  A61K36/47 ,  A61K36/82 ,  A61K36/886 ,  A61K47/10 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K2236/33 ,  A61K2236/51 ,  A61K2236/53 ,  A61L15/18 ,  A61L15/20 ,  A61L15/225 ,  A61L15/32 ,  A61L15/40 ,  A61L15/425 ,  A61L15/44 ,  A61L15/585 ,  A61L2300/104 ,  A61L2300/30 ,  A61L2300/404 ,  A61L2300/62 ,  A61L2300/802 ,  A61K2300/00

Abstract: This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.

公开(公告)号：US20180042775A1

公开(公告)日：2018-02-15

申请号：US15555673

申请日：2016-03-06

Applicant: Ryan Kendrick

Inventor： Ryan Kendrick

IPC: A61F13/02 ,  A61L15/58 ,  B32B5/02 ,  B32B7/06 ,  B32B7/12 ,  B32B27/36 ,  A61L15/22 ,  A61F13/00

CPC classification number: A61F13/0246 ,  A61F13/00059 ,  A61F13/0236 ,  A61F13/0259 ,  A61F13/06 ,  A61L15/225 ,  A61L15/26 ,  A61L15/58 ,  B32B5/024 ,  B32B7/06 ,  B32B7/12 ,  B32B27/36 ,  B32B2535/00 ,  C08L67/02

Abstract: The invention relates to a therapeutic adhesive tape for use in medical or sporting applications. The therapeutic tape is configured to be applied to the skin of a user. The tape comprising: a base layer having a face side and a back side, the base layer being composed of a combination of recycled polyethylene terephthalate (hereinafter: RPET) and an elastic material, and an adhesive layer deposited on one of said face side or back side of the base layer for attaching the tape to the skin of the user.

公开(公告)号：US20180008743A1

公开(公告)日：2018-01-11

申请号：US15696321

申请日：2017-09-06

Applicant: BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH ,  CARL FREUDENBERG KG

Inventor： Frank Plöger ,  Denis Reibel ,  Dirk Grafahrend ,  Daniel Neumüller

IPC: A61L15/32 ,  A61F13/00 ,  D04H1/30 ,  A61K38/18 ,  A61L15/22 ,  A61L15/64 ,  A61L15/62 ,  A61L15/44 ,  A61L15/42 ,  D04H1/4266 ,  A61L15/18

CPC classification number: A61L15/32 ,  A61F13/00 ,  A61K38/1875 ,  A61L15/18 ,  A61L15/22 ,  A61L15/325 ,  A61L15/42 ,  A61L15/425 ,  A61L15/44 ,  A61L15/62 ,  A61L15/64 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/604 ,  D04H1/30 ,  D04H1/4266

Abstract: The present invention is directed to novel non-woven fabrics containing growth and differentiation factor proteins. Said fabrics are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues. Furthermore, the invention provides wound dressings, pads or implants comprising the novel non-woven fabrics.

公开(公告)号：US20180008483A1

公开(公告)日：2018-01-11

申请号：US15656586

申请日：2017-07-21

Applicant: The Procter & Gamble Company

Inventor： John Lee Hammons ,  Raphael Warren ,  Ronald Bosman Visscher ,  Joseph Anthony Gatto ,  Brian Francis Gray ,  Amy Marie Price

IPC: A61F13/511 ,  A61L15/34 ,  A61L15/50 ,  A61L15/48 ,  A61L15/22 ,  A61F13/84

Abstract: The absorbent article of the invention has a liquid impervious backsheet and a liquid pervious topsheet joined to the backsheet. The topsheet has an inner surface oriented toward the interior of the absorbent article and an outer surface oriented toward the skin and hair of the wearer when the absorbent article is being worn and an absorbent core positioned between the topsheet and the backsheet. At least a portion of the topsheet outer surface comprises an effective amount of a lotion coating which is semi-solid or solid at 20 degrees C., the lotion coating comprising:(i) from about 10 to about 95% of a substantially water free emollient having a plastic or fluid consistency at 20 degrees C. wherein the emollient contains 5% or less water, the emollient comprising a member selected from the group consisting of petroleum-based emollients, fatty acid ester emollients, alkyl ethoxylate emollients, and mixtures thereof;(ii) from about 5 to about 90% of an agent capable of immobilizing the emollient on the outer surface of the topsheet, the immobilizing agent being miscible with the emollient, the immobilizing agent having a melting point of at least about 35 degrees C. wherein the immobilizing agent is selected from the group consisting of polyhydroxy fatty acid esters, polyhydroxy fatty acid amides, C14-C22 fatty alcohols, C14-C22 fatty acids, C14-C22 fatty alcohol ethoxylates with a degree of ethoxylation of 4 or less, and mixtures thereof.

公开(公告)号：US20180000664A1

公开(公告)日：2018-01-04

申请号：US15705360

申请日：2017-09-15

Applicant: The Procter & Gamble Company

Inventor： Astrid Annette Sheehan

IPC: A61F13/532 ,  A61F13/49 ,  A61F13/496 ,  A61F13/56 ,  A61F13/15 ,  A61F13/84 ,  A61L15/22 ,  A61F13/514

CPC classification number: A61F13/5323 ,  A61F13/15203 ,  A61F13/49009 ,  A61F13/49011 ,  A61F13/49012 ,  A61F13/496 ,  A61F13/51464 ,  A61F13/5638 ,  A61F13/84 ,  A61F2013/15357 ,  A61F2013/15373 ,  A61L15/22

Abstract: A disposable diaper having front and rear augmented waistband zones having a specified size and stiffness is disclosed. For relatively thinner, less bulky diapers of currently marketed designs, providing augmented waistband zones is believed to reduce mental and physical effort for the caregiver in application of the diaper. The augmented waistband zones provide a robust-feeling structure proximate the waist edges, which the caregiver may grasp at front and rear to adjust the diaper on the wearer. Caregiver perception of a need to reach deeper into the diaper structure to grasp it at a thicker area to tug at it is believed to be reduced.