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    Diagnosis and treatment of fluke infections with monoclonal antibodies
    94.
    发明授权
    Diagnosis and treatment of fluke infections with monoclonal antibodies 失效
    用单克隆抗体诊断和治疗吸虫感染

    公开(公告)号：US4530908A

    公开(公告)日：1985-07-23

    申请号：US489004

    申请日：1983-04-27

    申请人： Mette Strand

    发明人： Mette Strand

    IPC分类号： A61K38/00 ,  C07K16/20 ,  G01N33/577 ,  G01N33/48 ,  C12N15/00 ,  G01N33/56

    CPC分类号： G01N33/577 ,  C07K16/20 ,  A61K38/00 ,  Y10S435/948 ,  Y10S436/804 ,  Y10S436/811 ,  Y10S530/806 ,  Y10S530/809 ,  Y10S530/828 ,  Y10S530/855

    摘要： Antibodies and antigens are disclosed which provide a method of detecting and a method of combating flukes. A diagnostic method for the determination of an active fluke infection in a warm-blooded animal is provided which comprises the testing of body serum or body fluids for the presence of fluke spine glycoprotein or anti-spine antibodies. Fused cell hybrids ATCC HB-8086, ATCC HB-8087 and ATCC HB-8088, as well as the antibodies produced by the fused cell hybrids, are also provided.

    摘要翻译： 公开了提供一种检测方法的抗体和抗原以及一种防治吸虫的方法。 提供了用于测定温血动物中的活性吸虫感染的诊断方法，其包括测试身体血清或体液以存在侥幸脊柱糖蛋白或抗脊椎抗体。 还提供了融合细胞杂交瘤ATCC HB-8086，ATCC HB-8087和ATCC HB-8088，以及由融合细胞杂交体产生的抗体。

    Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
    96.
    发明授权
    Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells 失效
    用于选择性地控制外来核酸在动物或哺乳动物细胞中的不希望的表达或功能的方法

    公开(公告)号：US4511713A

    公开(公告)日：1985-04-16

    申请号：US363230

    申请日：1982-03-29

    申请人： Paul S. Miller ,  Paul O. P. Ts'O

    发明人： Paul S. Miller ,  Paul O. P. Ts'O

    IPC分类号： C07H21/00 ,  C07H15/12 ,  C07H17/00

    CPC分类号： C07H21/00 ,  Y10S530/808 ,  Y10S530/809

    摘要： A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for the nucleic acid and binding the nucleic acid with an appropriately prepared nonionic oligonucleoside alkyl or arylphosphonate analogue which is complementary to the indicated sequence of the foreign nucleic acid.

    摘要翻译： 选择性地控制或干扰外源核酸在其它正常活细胞存在下的作用或功能的方法，其包括确定核酸的碱基序列并将核酸与适当制备的非离子寡核苷酸烷基或芳基膦酸盐类似物结合 与指定的外源核酸序列互补。

    ANTI-HUMAN IL-21 ANTIBODIES
    99.
    发明申请
    ANTI-HUMAN IL-21 ANTIBODIES 审中-公开
    抗人IL-21抗体

    公开(公告)号：US20170037123A1

    公开(公告)日：2017-02-09

    申请号：US15177914

    申请日：2016-06-09

    申请人： ZymoGenetics, Inc.

    发明人： Pallavur V. SIVAKUMAR ,  Stephen R. JASPERS

    IPC分类号： C07K16/24

    CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30 ,  Y10S530/809

    摘要： Monoclonal antibodies are identified that bind the IL-21 protein. These antibodies are used to identify regions of the IL-21 protein to where binding neutralizes IL-21 activity. Hybridomas and methods of producing anti-IL-21 monoclonal antibodies are described. The monoclonal antibodies are useful in treating IL-21-mediated diseases, which may include autoimmune and inflammatory diseases such as pancreatitis, type I diabetes (IDDM), Graves Disease, inflammatory bowel disease (IBD), Crohn's Disease, ulcerative colitis, irritable bowel syndrome, multiple sclerosis, rheumatoid arthritis, diverticulosis, systemic lupus erythematosus, psoriasis, ankylosing spondylitis, scleroderma, systemic sclerosis, psoriatic arthritis, osteoarthritis, atopic dermatitis, vitiligo, graft vs. host disease (GVHD), cutaneous T cell lymphoma (CTCL), Sjogren's syndrome, glomerulonephritis, IgA nephropathy, graft versous host disease, transplant rejection, atopic dermatitis, anti-phospholipid syndrome, and asthma, and other autoimmune diseases.

    摘要翻译： 鉴定结合IL-21蛋白的单克隆抗体。 这些抗体用于鉴定结合中和IL-21活性的IL-21蛋白的区域。 描述了杂交瘤和产生抗IL-21单克隆抗体的方法。 单克隆抗体可用于治疗IL-21介导的疾病，其可能包括自身免疫性和炎性疾病如胰腺炎，I型糖尿病（IDDM），格雷夫斯病，炎性肠病（IBD），克罗恩病，溃疡性结肠炎，肠易激综合征 综合征，多发性硬化症，类风湿性关节炎，憩室病，系统性红斑狼疮，牛皮癣，强直性脊柱炎，硬皮病，系统性硬化症，银屑病关节炎，骨关节炎，特应性皮炎，白癜风，移植物抗宿主病（GVHD），皮肤T细胞淋巴瘤 ，干燥综合征，肾小球肾炎，IgA肾病，移植物宿主病，移植排斥反应，特应性皮炎，抗磷脂综合征，哮喘和其他自身免疫性疾病。