公开(公告)号：US09899212B2

公开(公告)日：2018-02-20

申请号：US15130208

申请日：2016-04-15

申请人： The University of Rochester

发明人： Alexander Shestopalov ,  James McGrath ,  Xunzhi Li

IPC分类号： H01L21/31 ,  H01L21/02 ,  C23C16/00 ,  C23C16/48

CPC分类号： H01L21/0228 ,  C23C16/00 ,  C23C16/482 ,  H01L21/02112

摘要： Methods and compositions for depositing a monolayer onto a surface of a substrate are described. The method can include contacting the surface with a vapor phase comprising a carbene source, and reacting a carbene group from the carbene source with a functional group on the surface, to obtain a covalently bound monolayer on the surface of the substrate. The carbene source can be a diazirine compound. The functional group on the surface can be a C—H containing group, a Si—H containing group, among others, or combinations thereof. The method can further involve removing physisorbed molecules from the surface of the substrate.

公开(公告)号：US20170344776A1

公开(公告)日：2017-11-30

申请号：US15596535

申请日：2017-05-16

申请人： Gaurav Sharma ,  Karthik Dinesh

发明人： Gaurav Sharma ,  Karthik Dinesh

IPC分类号： G06K7/14 ,  G06K1/12

CPC分类号： G06K7/1426 ,  G06K1/123 ,  G06K7/1443 ,  G06K7/146 ,  G06K19/06112 ,  G06K19/0614

摘要： A method of decoding a coherent RGB color barcode captured by a RGB camera includes: displaying a coherent RGB color barcode on the RGB display; capturing an image of the displayed barcode; performing a pilot block RGB color interference cancellation process to estimate a per pixel color interference; applying the per pixel color interference to the image of the displayed coherent RGB color barcode to extract each separate barcode of the coherent RGB color barcode; binarizing each of the three separate monochrome grey images of each barcode of the coherent RGB color barcode; and decoding each of the three separate binarized monochrome grey images to provide a decoded data for each barcode of the coherent RGB color barcode displayed on the RGB display. A method of decoding an incoherent RGB color barcode captured by a mobile device RGB camera is also described.

公开(公告)号：US20170330617A1

公开(公告)日：2017-11-16

申请号：US15657288

申请日：2017-07-24

申请人： Eby Friedman ,  Isaac Richter ,  Xiaochen Guo ,  Mohammad Kazemi ,  Kamil Pas ,  Ravi Patel ,  Engin Ipek ,  Ji Liu

发明人： Eby Friedman ,  Isaac Richter ,  Xiaochen Guo ,  Mohammad Kazemi ,  Kamil Pas ,  Ravi Patel ,  Engin Ipek ,  Ji Liu

IPC分类号： G11C13/00 ,  G11C7/16

CPC分类号： G11C13/004 ,  G11C7/16 ,  G11C13/0002 ,  G11C13/0069

摘要： Presented is a method and apparatus for solving. The method includes receiving, by a resistive memory array, a first data, the resistive memory array comprising a plurality of cells, wherein the receiving comprises setting a plurality of resistances on the plurality of cells, wherein each of the plurality of resistances are based on the first data. The method further includes receiving, by the resistive memory array, a second data, wherein the receiving comprises applying at least one of a current and a voltage based on the second data on the plurality of cells. The method still further includes determining, by the resistive memory array, an initial unknown value, the initial value based on the first data and the second data.

公开(公告)号：US09793178B2

公开(公告)日：2017-10-17

申请号：US14833540

申请日：2015-08-24

申请人： Miguel A. Alonso ,  Stephen Head ,  Michael Theisen ,  Thomas Brown

发明人： Miguel A. Alonso ,  Stephen Head ,  Michael Theisen ,  Thomas Brown

IPC分类号： H01L21/66 ,  G01B11/22 ,  G01N21/21 ,  G01N21/95 ,  G01B11/30 ,  G01B11/02 ,  G03F7/20

CPC分类号： H01L22/12 ,  G01B11/02 ,  G01B11/22 ,  G01B11/30 ,  G01B2210/56 ,  G01N21/21 ,  G01N21/9501 ,  G03F7/70625

摘要： The capacity to measure nanoscale features rapidly and accurately is of central importance for the monitoring of manufacturing processes in the production of computer integrated circuits. It is known that far-field scattered light requires a priori sample information in order to reconstruct nanoscale information such as is required in semiconductor metrology. Parameters of interest include, for example, trench depth, duty cycle, wall angle and oxide layer thickness. We describe a scatterometry apparatus and method that uses unconventional polarization states in the pupil of a high NA objective lens, and refer to this as focused beam scatterometry, in which the illumination consists of a focused field with a suitably tailored, spatially-varying polarization distribution. We describe how four or more parameters can be measured and distinguished with an accuracy consistent with the needs laid out in the semiconductor roadmap.

公开(公告)号：US09757428B2

公开(公告)日：2017-09-12

申请号：US14912098

申请日：2014-08-18

申请人： Benjamin L. Miller ,  Anna De Benedetto ,  Lisa A. Beck ,  Elizabeth A. Anderson

发明人： Benjamin L. Miller ,  Anna De Benedetto ,  Lisa A. Beck ,  Elizabeth A. Anderson

IPC分类号： A61K38/00 ,  A61K38/17 ,  A61K39/12 ,  A61K9/00 ,  A61K38/44 ,  A61K39/145 ,  C12N7/00 ,  A61K39/39 ,  A61K39/00

CPC分类号： A61K38/17 ,  A61K9/0014 ,  A61K9/0043 ,  A61K38/00 ,  A61K38/44 ,  A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/55516 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16134 ,  C12Y113/12007

摘要： According to aspects illustrated herein, there is provided an agent that transiently disrupts claudin-1 within tight junctions. The agent includes a peptide having at least 40% polar, uncharged amino acid residues and a self-assembled β-sheet secondary structure. According to aspects illustrated herein, there is also provided a transepithelial drug and vaccine formulations, as well as isolated peptides, pharmaceutical compositions, and transdermal delivery devices. Also described herein are methods of disrupting epithelial barrier and methods of administering the transepithelial formulations described herein.

公开(公告)号：US20170246139A1

公开(公告)日：2017-08-31

申请号：US15521623

申请日：2015-10-30

申请人： UNIVERSITY OF ROCHESTER ,  TEMPLE UNIVERSITY -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Paul M. Dunman ,  Wayne Childers

IPC分类号： A61K31/341 ,  A61K31/17 ,  A61K31/381 ,  A61K31/497 ,  A61K31/343 ,  A61K31/415 ,  A61K31/4409 ,  A61K31/4045 ,  A61K31/4184 ,  A61K31/47 ,  A61K31/44 ,  A61K45/06 ,  A61K31/351 ,  A61K47/10 ,  A61K9/06 ,  A61K9/00 ,  A61K31/443

CPC分类号： A61K31/341 ,  A61K9/0043 ,  A61K9/06 ,  A61K31/136 ,  A61K31/17 ,  A61K31/343 ,  A61K31/351 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/443 ,  A61K31/47 ,  A61K31/497 ,  A61K45/06 ,  A61K47/10 ,  A61K2300/00

摘要： Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the compositions to inhibit a bacterial tRNA synthetase in a cell and to decolonize bacteria on a surface.

公开(公告)号：US20170236284A1

公开(公告)日：2017-08-17

申请号：US15076309

申请日：2016-03-21

申请人： Ahmed S. Elliethy ,  Gaurav Sharma

发明人： Ahmed S. Elliethy ,  Gaurav Sharma

IPC分类号： G06T7/00

CPC分类号： G06T7/33 ,  G06T2207/10032 ,  G06T2207/30184 ,  G06T2207/30236 ,  G06T2207/30241

摘要： Methods for aligning images captured by aerial imaging platforms with a road network described by geo-referenced data, including the steps of: (a) identifying locations of moving vehicles in at least one image; (b) estimating a coordinate transformation that aligns the identified locations with the road network described by the geo-referenced data; and (c) outputting the estimated coordinate transformation or applying the estimated coordinate transformation to at least one image to align the image(s) with the road network described by the geo-referenced data. The methods may classify post-transformation detection as on-road detections or non-on-road detections to improve accuracy and synergistically use transformations and proximity to the road network to improve vehicle detection. The methods may identify vehicle trajectories to further improve accuracy and synergistically use transformations and proximity to the road network to improve estimates of vehicle trajectories.

公开(公告)号：US09733167B2

公开(公告)日：2017-08-15

申请号：US14398708

申请日：2013-05-06

申请人： Axel Wismueller ,  Andrzej Krol ,  Avice O'Connell

发明人： Axel Wismueller ,  Andrzej Krol ,  Avice O'Connell

IPC分类号： G01N33/483 ,  G01N1/36 ,  G01N23/04

CPC分类号： G01N1/36 ,  G01N23/04 ,  G01N33/4833 ,  G01N2223/307 ,  G01N2223/6126

摘要： An object, such as a tumor from a breast lumpectomy, is placed into an object positioning device that can hold the object without deforming it. Such a device can include a container with a deformable foam, gel, or other material. The object positioning device is moved into an imaging device. Images of the object within the object positioning device are acquired by the imaging device. The acquired images are stored, processed, or output on a display device. Information about the spatial orientation of the object with respect to a reference object is preserved.

公开(公告)号：US20170216332A1

公开(公告)日：2017-08-03

申请号：US15319254

申请日：2015-06-16

申请人： UNIVERSITY OF ROCHESTER

发明人： Richard P. Phipps ,  Collynn Woeller

IPC分类号： A61K31/7048 ,  A61K31/351 ,  A61K31/47 ,  A61K31/4409 ,  A61K31/167 ,  A61K31/166 ,  A61K31/341 ,  A61K31/519 ,  A61K31/4412 ,  A61K31/381 ,  A61K31/5375 ,  A61K31/635 ,  A61K31/4184 ,  A61K31/549 ,  A61K31/415 ,  A61K31/551 ,  A61K45/06

CPC分类号： A61K31/7048 ,  A61K31/095 ,  A61K31/155 ,  A61K31/166 ,  A61K31/167 ,  A61K31/341 ,  A61K31/35 ,  A61K31/351 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/473 ,  A61K31/4745 ,  A61K31/519 ,  A61K31/5375 ,  A61K31/549 ,  A61K31/551 ,  A61K31/635 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed are methods of treating fibrosis in a patient in need thereof that includes administering to the patient an amount of an active agent, as identified herein, that is therapeutically effective to inhibit myofibroblast formation and thereby treat the fibrosis. Also disclosed is a recombinant cell line that includes a recombinant gene that expresses a detectable expression product in a dose-dependent response to TGFβ, as well as methods of identifying a compound that inhibits TGFβ-mediated expression of the detectable expression product.

公开(公告)号：US09709553B2

公开(公告)日：2017-07-18

申请号：US12990874

申请日：2009-05-07

申请人： Steven Goldman ,  Fraser J. Sim

发明人： Steven Goldman ,  Fraser J. Sim

IPC分类号： A61K35/30 ,  G01N33/50 ,  C12N5/079 ,  C12N5/0797 ,  A61K35/12

CPC分类号： A61K35/30 ,  A61K35/12 ,  C07K14/70596 ,  C12N5/0622 ,  C12N5/0623 ,  C12N9/1276 ,  G01N33/5058

摘要： The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.