公开(公告)号：US20120052524A1

公开(公告)日：2012-03-01

申请号：US13254040

申请日：2010-03-04

Applicant: Masahiro Kinooka ,  Yasunori Takezawa ,  Masahito Taya ,  Atsuhiro Saito ,  Yoshiki Sawa ,  Tatsuya Shimizu ,  Teruo Okano

Inventor： Masahiro Kinooka ,  Yasunori Takezawa ,  Masahito Taya ,  Atsuhiro Saito ,  Yoshiki Sawa ,  Tatsuya Shimizu ,  Teruo Okano

IPC: C12Q1/02 ,  C12M1/34

CPC classification number: G01N33/5008 ,  C12M41/46 ,  C12Q1/025 ,  G01N33/5026 ,  G01N33/5029 ,  G01N33/5064

Abstract: Three-dimensional information on a biological parameter relating to at least one selected from viability, proliferating ability, migration, and differentiation of cultured cells can be obtained by a simple two-dimensional analytical technique by constructing a cell evaluation system including a multilayered cell sheet, target cells, and a two-dimensional analyzer.

Abstract translation: 通过简单的二维分析技术，可以通过构建包括多层细胞片的细胞评估系统来获得关于选自生殖力，增殖能力，迁移和培养细胞分化中的至少一种的生物学参数的三维信息， 靶细胞和二维分析仪。

公开(公告)号：US20090011504A1

公开(公告)日：2009-01-08

申请号：US12230916

申请日：2008-09-08

Applicant: Kazunori Kataoka ,  Hidenori Otsuka ,  Teruo Okano ,  Yukio Nagasaki ,  Yasuhiro Horiike

Inventor： Kazunori Kataoka ,  Hidenori Otsuka ,  Teruo Okano ,  Yukio Nagasaki ,  Yasuhiro Horiike

IPC: C12N5/06

CPC classification number: C12N5/0671 ,  C12N5/0697 ,  C12N2502/14 ,  C12N2502/28 ,  C12N2533/30 ,  C12N2533/40 ,  C12N2535/10

Abstract: Parenchymal cells are cultivated on cultivated endothelial cells or cultivated fibroblasts which have been separated by a surface of a specific hydrophilic polymer, and which have been patterned. A culture which contains thus formed patterned spheroids of cultivated parenchymal cells is thereby provided by this invention. This culture maintains a function which is specific to the parenchymal cells over a long period of time.

Abstract translation: 将实质细胞培养在培养的内皮细胞或培养的成纤维细胞上，这些成纤维细胞已经被特定的亲水性聚合物的表面分离并且已被图案化。 因此本发明提供了含有如此形成的培养实质细胞的图案化球体的培养物。 该培养物保持长时间对实质细胞特异的功能。

公开(公告)号：US20050224415A1

公开(公告)日：2005-10-13

申请号：US11132675

申请日：2005-05-19

Applicant: Yoshikatsu Akiyama ,  Kimihiro Yoshizako ,  Yukio Hasegawa ,  Teruo Okano

Inventor： Yoshikatsu Akiyama ,  Kimihiro Yoshizako ,  Yukio Hasegawa ,  Teruo Okano

IPC: B01J20/26 ,  C08F20/28 ,  C08F20/36 ,  C08F20/58 ,  C08F20/60 ,  G01N30/54 ,  B01D15/08

CPC classification number: B01J20/265 ,  B01D15/20 ,  B01D15/3876 ,  B01J20/261 ,  B01J20/285 ,  B01J2220/54 ,  C08F20/28 ,  C08F20/36 ,  C08F20/58 ,  C08F20/60 ,  C08F220/60 ,  G01N30/54

Abstract: A temperature-responsive polymer and polymer material which has ester bond(s) and/or acid amide bond(s) respectively at one or more sites in the side chain and can be arbitrarily controlled by varying the side chain is provided. The process for production thereof and the use thereof are also provided.

Abstract translation: 提供了在侧链的一个或多个位置处分别具有酯键和/或酰胺键的温度敏感性聚合物和聚合物材料，并且可以通过改变侧链任意控制。 还提供了其生产方法及其用途。

公开(公告)号：US6090317A

公开(公告)日：2000-07-18

申请号：US361958

申请日：1999-07-27

Applicant: Kazunori Kataoka ,  Yukio Nagasaki ,  Masao Kato ,  Teruo Okano ,  Teruo Nakamura

Inventor： Kazunori Kataoka ,  Yukio Nagasaki ,  Masao Kato ,  Teruo Okano ,  Teruo Nakamura

IPC: C08G65/32 ,  A61K47/48 ,  C08G63/664 ,  C08G65/26 ,  C08G65/329 ,  C08L71/02 ,  B01J13/02 ,  B01J13/04 ,  B01J13/20

CPC classification number: A61K47/48215 ,  A61K47/488 ,  C08G63/664 ,  C08G65/2606 ,  C08G65/329 ,  C08L71/02 ,  Y10T428/2984 ,  Y10T428/2985

Abstract: This invention provides a heterotelechelic oligomer or polymer which is represented by the following formula: ##STR1## wherein A denotes a sugar residue, L denotes a linkage group represented by the following formula ##STR2## wherein R.sup.1 and R.sup.2 independently denote lower alkyl, aralkyl or aryl,X denotes a single bond or --CH.sub.2 CH.sub.2 --, Z denotes a group forming an unsaturated ester or ether, or a functional group such as halogen which binds to --CH.sub.2 CH.sub.2 --, n denotes an integer of 5-10,000, and m denotes an integer of 0 or 2-10,000.This invention also provides a process to produce the above oligomer or polymer, and further a high molecular-micelle with use of a polyethylene oxide-polyester block polymer which has a sugar residue at its terminal. Said oligomer or polymer is expected to exhibit excellent bioavailability, and is also expected to be utilized in the field such as carriers for drug delivery or diagnostic reagents.

Abstract translation: 本发明提供了由下式表示的异炔属低聚物或聚合物：其中A表示糖残基，L表示由下式表示的连接基团，其中R 1和R 2独立地表示低级烷基，芳烷基或芳基，X表示单 键或-CH 2 CH 2 - ，Z表示不饱和酯或醚的基团，或与-CH 2 CH 2 - 结合的官能团例如卤素，n表示5-10,000的整数，m表示0或2的整数， 10,000。 本发明还提供了使用在其末端具有糖残基的聚环氧乙烷 - 聚酯嵌段聚合物制备上述低聚物或聚合物以及进一步的高分子量胶束的方法。 预期所述低聚物或聚合物表现出优异的生物利用度，并且还预期在现场使用，例如用于药物递送或诊断试剂的载体。

公开(公告)号：US5510103A

公开(公告)日：1996-04-23

申请号：US465499

申请日：1995-06-05

Applicant: Masayuki Yokoyama ,  Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka

Inventor： Masayuki Yokoyama ,  Yasuhisa Sakurai ,  Teruo Okano ,  Kazunori Kataoka

IPC: A61K9/00 ,  A61K9/107 ,  A61K9/51 ,  A61K47/34 ,  A61K47/48 ,  C08G69/10 ,  A61K31/74 ,  A61K9/127

CPC classification number: C08G69/10 ,  A61K9/1075 ,  Y10T428/2985 ,  Y10T428/2989

Abstract: The present invention relates to drug carriers composed of a block copolymer having hydrophilic and hydrophobic segments, a polymeric micelle type drug comprising hydrophobic drugs trapped by physical treatments in said drug carrier and methods for trapping hydrophobic drugs in the drug carrier. The drugs carrier composed of the block copolymer according to the invention forms a stable polymeric micelle structure with which hydrophobic drugs can be incorporated very efficiently via physical trapping. It was found that the incorporated drug is stably maintained in micelles even in the presence of serum. In addition, a drug difficult to administer into the living body owing to sparing water-solubility for its high hydrophobicity can be administered in the form of polymeric micelle drug.

公开(公告)号：US5228370A

公开(公告)日：1993-07-20

申请号：US824877

申请日：1992-01-24

Applicant: Akira Yanagisawa ,  Teruo Okano

Inventor： Akira Yanagisawa ,  Teruo Okano

IPC: B29B9/02 ,  B29B9/14 ,  G11C8/00

CPC classification number: G11C8/00 ,  B29B9/02 ,  B29B9/14 ,  Y10T156/1052 ,  Y10T156/1061 ,  Y10T156/108 ,  Y10T82/10

Abstract: A method of manufacturing a molding material includes the steps of winding a thin metal strip on the peripheral surface of a rotary shaft a plurality of turns with a resin material being interposed between the resulting layers of metal, cutting an end surface of the metal strip and the resin material which have been wound by a cutting blade while rotating said rotary shaft to obtain a mixture of metal fibers and resin fibers, and heating the fiber mixture to a temperature at which the resin fibers can be softened. In this way, a molding material in which the metal fibers are substantially uniformly dispersed in the resin material in a closely contacted state can be obtained easily. Furthermore, the contents of the metal fibers by volume in the molding material can be arbitrarily adjusted by changing the rate at which the metal strip and the resin material are wound around the rotary shaft.

Abstract translation: 制造成型材料的方法包括以下步骤：在旋转轴的圆周表面上缠绕多个匝，其中树脂材料插入在所得的金属层之间，切割金属带的端面和 所述树脂材料在旋转所述旋转轴的同时由切割刀片卷绕以获得金属纤维和树脂纤维的混合物，并且将所述纤维混合物加热到所述树脂纤维可以软化的温度。 以这种方式，可以容易地获得其中金属纤维基本均匀地分散在树脂材料中的紧密接触状态的成型材料。 此外，可以通过改变金属带和树脂材料缠绕在旋转轴上的速率来任意调节成型材料中的金属纤维的体积含量。