公开(公告)号：US08022191B2

公开(公告)日：2011-09-20

申请号：US11498053

申请日：2006-08-03

Applicant: Teruo Nakamura ,  Yasuo Sekimori ,  Minoru Machida ,  Hiromitsu Kawata ,  Hajime Miyamoto

Inventor： Teruo Nakamura ,  Yasuo Sekimori ,  Minoru Machida ,  Hiromitsu Kawata ,  Hajime Miyamoto

IPC: A61K38/18

CPC classification number: C07K14/505 ,  A61K38/1816 ,  A61K47/60

Abstract: The present invention provides a polyethylene glycol-conjugated erythropoietin (PEG-conjugated EPO) prepared by PEG conjugation on the lysine residue at position 52 of native erythropoietin (native EPO). In order to achieve more sustained efficacy without losing physiological activities of native EPO, a glycoprotein rich in sugar chains, there has been a need to develop a PEG-conjugated EPO with significantly sustained efficacy by introducing a controlled number of PEG molecules at controlled positions. This PEG-conjugated EPO addresses such a need and provides more sustained efficacy.

Abstract translation: 本发明提供通过PEG缀合在天然促红细胞生成素（天然EPO）的52位的赖氨酸残基上制备的聚乙二醇缀合的促红细胞生成素（PEG-缀合的EPO）。 为了获得更持久的功效而不损失富含糖链的糖蛋白的天然EPO的生理活性，需要通过在受控位置引入受控数量的PEG分子来开发具有显着持续功效的PEG-缀合的EPO。 这种PEG结合的EPO解决了这种需要并提供更持久的功效。

公开(公告)号：US06526040B1

公开(公告)日：2003-02-25

申请号：US09332966

申请日：1999-06-15

Applicant: Teruo Nakamura

Inventor： Teruo Nakamura

IPC: H04J1500

CPC classification number: H04Q3/0016 ,  H04Q2213/1329 ,  H04Q2213/1338 ,  H04Q2213/13389

Abstract: An interface connected to a local area network is mounted in each of data transfer circuits 19, 1a to 1c, 28, 29 and 36 for establishing logical connection of exchanges to one another such that it can connect a plurality of data transfer circuits provided in each exchange to one another. It is thus possible to obtain joint establishment of a logical mesh structure by individual data transfer circuits and, when a data transfer circuit receives data to be transferred to a different exchange from its own, obtain alleviation of the load in the own exchange with a process of data transfer between the data transfer circuits that is executed by using the local area network side interface.

Abstract translation: 连接到局域网的接口安装在每个数据传输电路19,1a至1c，28,29和36中，用于建立彼此之间的交换的逻辑连接，使得它可以连接多个数据传输电路 互相交流 因此，可以通过单独的数据传输电路来获得逻辑网格结构的联合建立，并且当数据传送电路从其自身接收到要传送到不同交换机的数据时，获得在自己交换中的负载的减轻与过程 在通过使用局域网侧接口执行的数据传送电路之间进行数据传送。

公开(公告)号：US5586254A

公开(公告)日：1996-12-17

申请号：US18430

申请日：1993-02-16

Applicant: Mariko Kondo ,  Teruo Nakamura ,  Yumiko Mori ,  Toshiyuki Tsutsumi

Inventor： Mariko Kondo ,  Teruo Nakamura ,  Yumiko Mori ,  Toshiyuki Tsutsumi

IPC: H04L12/24 ,  G06F15/40 ,  G06F13/94 ,  G06F15/66

CPC classification number: H04L41/0677 ,  H04L41/0836 ,  H04L41/0846 ,  H04L41/0856 ,  H04L41/12 ,  H04L41/22 ,  Y10S707/99945 ,  Y10S707/99948

Abstract: A system for operating and managing the network equipment is so adapted as to operate and manage a network in which plural computers and network devices are connected to each other. The system is provided with database storing data corresponding to the computers and the network devices and with means for preparing a network specification drawing which satisfies conditions required by the user from the data, for checking the physical data as to whether the network specification satisfies the physical data, for checking the logical data as to whether the network specification satisfies the logical data, and for displaying the network specification drawing in a two-dimensional or three-dimensional manner on the basis of the data stored in the database. The system for operating and managing the network equipment can reduce and simplify management business for network managers as well as management business for managing materials and products by managers managing the materials and products. Further, the system can take necessary measures in case of a fault or a failure of the network and save a resource by sharing the computer resources and the data in an appropriate way.

Abstract translation: 用于操作和管理网络设备的系统适于操作和管理多个计算机和网络设备彼此连接的网络。 该系统具有对应于计算机和网络设备的数据库存储数据，并且具有用于准备满足用户从数据所需的条件的网络规范图，用于检查物理数据以确定网络规范是否满足物理 数据，用于检查关于网络规范是否满足逻辑数据的逻辑数据，以及基于存储在数据库中的数据以二维或三维方式显示网络规范图。 运营和管理网络设备的系统可以减少和简化网络管理员的管理业务，以及管理材料和产品的管理人员管理材料和产品的管理业务。 此外，系统可以在发生故障或网络故障的情况下采取必要措施，并以适当的方式共享计算机资源和数据来节省资源。

公开(公告)号：US4756947A

公开(公告)日：1988-07-12

申请号：US883716

申请日：1986-07-09

Applicant: Toshio Nishikawa ,  Shiro Imai ,  Kenkichi Yagi ,  Yuriko Yoshida ,  Masato Shimada ,  Junnosuke Nagashima ,  Teruo Nakamura

Inventor： Toshio Nishikawa ,  Shiro Imai ,  Kenkichi Yagi ,  Yuriko Yoshida ,  Masato Shimada ,  Junnosuke Nagashima ,  Teruo Nakamura

IPC: C08G18/48 ,  D06N3/14 ,  D06P3/24 ,  D06P5/02 ,  D06P5/04

CPC classification number: C08G18/4833 ,  D06N3/14 ,  D06N3/146 ,  D06P3/241 ,  D06P3/248 ,  D06P5/02 ,  Y10S428/904 ,  Y10T428/24438 ,  Y10T442/2008 ,  Y10T442/2893

Abstract: Artificial leather and a dyeing method therefor; the leather includes ultrafine polyamide fibers and is particularly a grained artificial leather having bright, deep color, good color fastness to dry cleaning with charged soap, a delicate touch free from any undesirable rubber-like feeling, as well as high durability.A super-entangled fiber base is provided comprising ultrafine polyamide fibers and/or bundles thereof; polyurethane including polyoxyethylene of molecular weight of 500-5,000 is applied. The polyamide ultrafine fibers are dyed with a metal-dye complex and a fixing agent.

Abstract translation: 人造革及其染色方法; 皮革包括超细聚酰胺纤维，特别是具有明亮，深色，具有良好色牢度的带有肥皂的干净的细粒人造革，没有任何不期望的橡胶状感觉的微妙触感以及高耐久性。 提供了包含超细聚酰胺纤维和/或其束的超缠结纤维基材; 使用分子量为500-5,000的聚氧乙烯的聚氨酯。 聚酰胺超细纤维用金属染料络合物和固色剂染色。

公开(公告)号：US4611977A

公开(公告)日：1986-09-16

申请号：US640312

申请日：1984-08-13

Applicant: Tsunenori Shibuya ,  Yutaka Ishizuka ,  Haruhiko Takada ,  Teruo Nakamura ,  Hidehiko Takayama

Inventor： Tsunenori Shibuya ,  Yutaka Ishizuka ,  Haruhiko Takada ,  Teruo Nakamura ,  Hidehiko Takayama

IPC: F04C18/344 ,  F01C21/08 ,  F04C18/00

CPC classification number: F01C21/0872

Abstract: A vane compressor has a vane back pressure adjustment device including back-pressure chambers defined in a vane-supporting rotor and surrounded by vanes and side blocks secured to axial ends of a cylinder. The back-pressure chamber has axial ends disposed to follow a path against each of the side blocks when the rotor rotates. The path is divided into at least one high-pressure zone in which the vanes move across a pump outlet defined in the cylinder, and at least one normal-pressure zone which is the remainder of the path. In the normal-pressure zone, oil grooves defined in surfaces of the side blocks which face the rotor and supplied with oil from an oil sump in the vane compressor are in communication with the back-pressure chambers, to thereby maintain the oil pressure in the back-pressure chambers at a pressure level in the oil sump. In the high-pressure zone, the back-pressure chambers are out of communication with the oil grooves so that the oil fed into the back-pressure chambers is confined therein, except through a restrictor means. When the vanes move across the pump outlet, the vanes enter the high-pressure zone to trap oil in the back-pressure chambers to thereby elevate the oil pressure in the back-pressure chambers to a high level. Therefore, the vanes are prevented from being retracted deeply into vane slits in the rotor and then popping out into hitting engagement with the cylinder.

公开(公告)号：US4311758A

公开(公告)日：1982-01-19

申请号：US211780

申请日：1980-12-01

Applicant: Yoshitaka Oeda ,  Takeshi Murakami ,  Hiroo Hayashi ,  Teruo Nakamura

Inventor： Yoshitaka Oeda ,  Takeshi Murakami ,  Hiroo Hayashi ,  Teruo Nakamura

IPC: B41M5/337 ,  B32B5/16 ,  B41M5/18

CPC classification number: B41M5/3377 ,  Y10S428/913 ,  Y10S430/165 ,  Y10T428/259 ,  Y10T428/273 ,  Y10T428/277

Abstract: In a heat-sensitive record material comprising a base sheet and a color developing layer formed thereon, a pigment having an oil absorption within the range of 80 to 800 ml/100 g is additionally included in the color developing layer.

Abstract translation: 在包含基片和形成在其上的彩色显影层的热敏记录材料中，在彩色显影层中还包括吸油率在80至800ml / 100g范围内的颜料。

公开(公告)号：US4285207A

公开(公告)日：1981-08-25

申请号：US59723

申请日：1979-07-23

Applicant: Hiroyuki Sugiura ,  Ryota Hasegawa ,  Teruo Nakamura

Inventor： Hiroyuki Sugiura ,  Ryota Hasegawa ,  Teruo Nakamura

IPC: B60H1/32 ,  F25B49/00 ,  G01F23/74 ,  G05D23/275 ,  B60H3/04 ,  G05D23/32

CPC classification number: G05D23/275 ,  B60H1/3225 ,  F25B49/005 ,  G01F23/74 ,  F25B2500/222 ,  F25B2700/04

Abstract: A float operated switch (21) is actuated when the level of refrigerant fluid in a reservoir (11) is below a predetermined value to produce an electrical signal. The signal is delayed by 10 to 30 seconds and applied to a switch circuit (54) to disengage an electromagnetic clutch (63) and thereby de-energize a compressor (64). The clutch (63) is also disengaged by the action of a thermal switch (61) when the temperature in a space which is being air conditioned drops below a predetermined value. The operation of the float operated switch (21) is inhibited when the sensed temperature is below the predetermined value and also when a motor which drives the compressor (64) is not operating to prevent erroneous de-energization of the compressor (64).

Abstract translation: 当储存器（11）中的制冷剂流体的水平低于预定值时，浮动操作开关（21）被致动以产生电信号。 信号被延迟10至30秒，并施加到开关电路（54）以使电磁离合器（63）脱离，从而使压缩机（64）断电。 当被空调的空间中的温度下降到预定值以下时，离合器（63）也通过热开关（61）的作用而脱离。 当感测到的温度低于预定值时，以及当驱动压缩机（64）的电动机不工作以防止压缩机（64）的错误断电时，禁止浮动操作开关（21）的操作。

公开(公告)号：US20050148763A1

公开(公告)日：2005-07-07

申请号：US10503075

申请日：2003-02-03

Applicant: Yasuo Sekimori ,  Teruo Nakamura ,  Masaru Shimizu

Inventor： Yasuo Sekimori ,  Teruo Nakamura ,  Masaru Shimizu

IPC: A61K38/29 ,  A61K47/48 ,  A61P19/00 ,  C07K14/635

CPC classification number: C07K14/635 ,  A61K38/29 ,  A61K47/60

Abstract: The object of the present invention is to provide PTH or a PTH derivative, which is modified to attain increased bioavailability without losing PTH activity and to have a reduced risk of side effects. PEG conjugation to PTH or a PTH derivative increases the bioavailability while maintaining PTH activity and also reduces side effects.

Abstract translation: 本发明的目的是提供PTH或PTH衍生物，其被修饰以获得增加的生物利用度而不丧失PTH活性并降低副作用的风险。 与PTH或PTH衍生物的PEG缀合增加了生物利用度，同时保持PTH活性并且还降低了副作用。

公开(公告)号：US6012898A

公开(公告)日：2000-01-11

申请号：US101894

申请日：1999-02-16

Applicant: Teruo Nakamura ,  Fumio Kobayashi ,  Hideharu Watanabe

Inventor： Teruo Nakamura ,  Fumio Kobayashi ,  Hideharu Watanabe

IPC: F04D29/04 ,  F04D29/047 ,  F04D29/049 ,  F04B17/03

CPC classification number: F04D29/047 ,  F04D29/049 ,  F16C21/00 ,  F16C39/02

Abstract: A submerged motor pump (4) has an auxiliary bearing assembly (19, 20) for supporting a rotatable main shaft (9) when the submerged motor pump is not in an operating condition or operates in a transient condition. The submerged motor pump includes a pump casing (6), at least one impeller (12), a motor (10,11), and a thrust balancing mechanism (15) for balancing thrust forces. The submerged motor pump further includes hydrostatic bearings (16, 17, 18) for supporting the main shaft at axially spaced locations by a pressurized fluid pumped by the submerged motor pump. The auxiliary bearing assembly has tapered support surfaces (FL, FU) for supporting the main shaft at the axially spaced locations.

Abstract translation: PCT No.PCT / US97 / 09291 Sec。 371日期1999年2月16日 102（e）1999年2月16日PCT 1997年6月6日PCT公布。 公开号WO97 / 46806 日期1997年12月11日潜水电动泵（4）具有辅助轴承组件（19,20），用于当潜水电动泵不处于运行状态或在瞬态状态下运行时支撑可旋转主轴（9）。 潜水电机泵包括泵壳体（6），至少一个叶轮（12），马达（10,11）和用于平衡推力的推力平衡机构（15）。 潜水电动泵还包括静压轴承（16,17,18），用于通过被潜水电动泵泵送的加压流体在轴向间隔开的位置处支撑主轴。 辅助轴承组件具有用于在轴向间隔开的位置处支撑主轴的锥形支撑表面（FL，FU）。

公开(公告)号：US5973069A

公开(公告)日：1999-10-26

申请号：US930855

申请日：1997-12-18

Applicant: Kazunori Kataoka ,  Yukio Nagasaki ,  Masao Kato ,  Teruo Okano ,  Teruo Nakamura

Inventor： Kazunori Kataoka ,  Yukio Nagasaki ,  Masao Kato ,  Teruo Okano ,  Teruo Nakamura

IPC: C08G65/32 ,  A61K47/48 ,  C08G63/664 ,  C08G65/26 ,  C08G65/329 ,  C08L71/02 ,  C08G65/08

CPC classification number: A61K47/48215 ,  A61K47/488 ,  C08G63/664 ,  C08G65/2606 ,  C08G65/329 ,  C08L71/02 ,  Y10T428/2984 ,  Y10T428/2985

Abstract: This invention provides a heterotelechelic oligomer or polymer which is represented by the following formula: ##STR1## wherein A denotes a sugar residue, L denotes a linkage group represented by the following formula ##STR2## wherein R.sup.1 and R.sup.2 independently denote lower alkyl, aralkyl or aryl,X denotes a single bond or --CH.sub.2 CH--, Z denotes a group forming an unsaturated ester or ether, or a functional group such as halogen which binds to --CH.sub.2 CH.sub.2 --, n denotes an integer of 5-10,000, and m denotes an integer of 0 or 2-10,000.This invention also provides a process to produce the above oligomer or polymer, and further a high molecular-micelle with use of a polyethylene oxide-polyester block polymer which has a sugar residue at its terminal. Said oligomer or polymer is expected to exhibit excellent bioavailability, and is also expected to be utilized in the field such as carriers for drug delivery or diagnostic reagents.

Abstract translation: PCT No.PCT / JP96 / 01020 Sec。 371 1997年12月18日第 102（e）日期1997年12月18日PCT提交1996年4月12日PCT公布。 公开号WO96 / 32434 日本特开1996年10月17日本发明提供由下式表示的异炔属低聚物或聚合物：其中A表示糖残基，L表示由下式表示的连接基团，其中R 1和R 2独立地表示低级烷基，芳烷基或芳基 X表示单键或-CH 2 CH-，Z表示形成不饱和酯或醚的基团，或与-CH 2 CH 2 - 结合的卤素等官能团，n表示5-10,000的整数，m表示整数 为0或2-10,000。 本发明还提供了使用在其末端具有糖残基的聚环氧乙烷 - 聚酯嵌段聚合物制备上述低聚物或聚合物以及进一步的高分子量胶束的方法。 预期所述低聚物或聚合物表现出优异的生物利用度，并且还预期在现场使用，例如用于药物递送或诊断试剂的载体。